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Protein

ATP synthase subunit alpha

Gene

atpA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.UniRule annotation

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei363 – 3631Required for activityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi170 – 1778ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit alphaUniRule annotation (EC:3.6.3.14UniRule annotation)
Alternative name(s):
ATP synthase F1 sector subunit alphaUniRule annotation
F-ATPase subunit alphaUniRule annotation
Gene namesi
Name:atpAUniRule annotation
Ordered Locus Names:TM_1612
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, CF(1), Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503ATP synthase subunit alphaPRO_0000238387Add
BLAST

Proteomic databases

PRIDEiQ9X1U7.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.UniRule annotation

Protein-protein interaction databases

STRINGi243274.TM1612.

Structurei

Secondary structure

1
503
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni25 – 273Combined sources
Beta strandi28 – 358Combined sources
Beta strandi38 – 436Combined sources
Beta strandi51 – 555Combined sources
Turni56 – 583Combined sources
Beta strandi61 – 666Combined sources
Beta strandi72 – 787Combined sources
Beta strandi88 – 958Combined sources
Beta strandi97 – 1015Combined sources
Helixi102 – 1043Combined sources
Beta strandi117 – 1193Combined sources
Beta strandi125 – 1306Combined sources
Helixi137 – 1393Combined sources
Beta strandi145 – 1473Combined sources
Helixi152 – 1576Combined sources
Beta strandi165 – 1717Combined sources
Helixi176 – 18510Combined sources
Turni186 – 1916Combined sources
Beta strandi192 – 2009Combined sources
Helixi203 – 21513Combined sources
Helixi218 – 2214Combined sources
Beta strandi222 – 2276Combined sources
Helixi233 – 25119Combined sources
Turni252 – 2543Combined sources
Beta strandi256 – 2627Combined sources
Helixi264 – 27613Combined sources
Helixi291 – 2999Combined sources
Beta strandi303 – 3053Combined sources
Turni307 – 3104Combined sources
Beta strandi313 – 32311Combined sources
Helixi330 – 3378Combined sources
Beta strandi339 – 3457Combined sources
Helixi347 – 3526Combined sources
Turni360 – 3623Combined sources
Helixi366 – 3683Combined sources
Turni369 – 3713Combined sources
Helixi374 – 39421Combined sources
Helixi397 – 3993Combined sources
Helixi405 – 42016Combined sources
Helixi431 – 44212Combined sources
Turni443 – 4486Combined sources
Helixi451 – 4533Combined sources
Helixi454 – 46815Combined sources
Helixi470 – 47910Combined sources
Helixi484 – 50017Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2R9VX-ray2.10A2-503[»]
ProteinModelPortaliQ9X1U7.
SMRiQ9X1U7. Positions 17-503.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X1U7.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDG. Bacteria.
COG0056. LUCA.
InParanoidiQ9X1U7.
KOiK02111.
OMAiQVVSIWA.

Family and domain databases

CDDicd01132. F1_ATPase_alpha. 1 hit.
Gene3Di2.40.30.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01346. ATP_synth_alpha_bact. 1 hit.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR023366. ATPase_asu-like.
IPR005294. ATPase_F1-cplx_asu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR033732. F1_ATPase_alpha.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15184:SF3. PTHR15184:SF3. 1 hit.
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
PIRSFiPIRSF039088. F_ATPase_subunit_alpha. 1 hit.
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00962. atpA. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X1U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRINPGEITK VLEEKIKSFE EKIDLEDTGK VIQVGDGIAR AYGLNKVMVS
60 70 80 90 100
ELVEFVETGV KGVAFNLEED NVGIIILGEY KDIKEGHTVR RLKRIIEVPV
110 120 130 140 150
GEELLGRVVN PLGEPLDGKG PINAKNFRPI EIKAPGVIYR KPVDTPLQTG
160 170 180 190 200
IKAIDSMIPI GRGQRELIIG DRQTGKTAIA IDTIINQKGQ GVYCIYVAIG
210 220 230 240 250
QKKSAIARII DKLRQYGAME YTTVVVASAS DPASLQYIAP YAGCAMGEYF
260 270 280 290 300
AYSGRDALVV YDDLSKHAVA YRQLSLLMRR PPGREAYPGD IFYLHSRLLE
310 320 330 340 350
RAVRLNDKLG GGSLTALPIV ETQANDISAY IPTNVISITD GQIYLEPGLF
360 370 380 390 400
YAGQRPAINV GLSVSRVGGS AQIKAMKQVA GMLRIDLAQY RELETFAQFA
410 420 430 440 450
TELDPATRAQ IIRGQRLMEL LKQEQYSPMP VEEQVVVLFA GVRGYLDDLP
460 470 480 490 500
VEEVRRFEKE FLRFMHEKHQ DILDDIKTKK ELTSETEEKL KKAIEEFKTT

FRV
Length:503
Mass (Da):56,062
Last modified:November 1, 1999 - v1
Checksum:i886C9736F16BF149
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36679.1.
PIRiF72231.
RefSeqiNP_229412.1. NC_000853.1.
WP_004082064.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36679; AAD36679; TM_1612.
GeneIDi897935.
KEGGitma:TM1612.
tmi:THEMA_06190.
tmw:THMA_1652.
PATRICi23938198. VBITheMar51294_1631.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36679.1.
PIRiF72231.
RefSeqiNP_229412.1. NC_000853.1.
WP_004082064.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2R9VX-ray2.10A2-503[»]
ProteinModelPortaliQ9X1U7.
SMRiQ9X1U7. Positions 17-503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1612.

Proteomic databases

PRIDEiQ9X1U7.

Protocols and materials databases

DNASUi897935.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36679; AAD36679; TM_1612.
GeneIDi897935.
KEGGitma:TM1612.
tmi:THEMA_06190.
tmw:THMA_1652.
PATRICi23938198. VBITheMar51294_1631.

Phylogenomic databases

eggNOGiENOG4105CDG. Bacteria.
COG0056. LUCA.
InParanoidiQ9X1U7.
KOiK02111.
OMAiQVVSIWA.

Miscellaneous databases

EvolutionaryTraceiQ9X1U7.

Family and domain databases

CDDicd01132. F1_ATPase_alpha. 1 hit.
Gene3Di2.40.30.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01346. ATP_synth_alpha_bact. 1 hit.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR023366. ATPase_asu-like.
IPR005294. ATPase_F1-cplx_asu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR033732. F1_ATPase_alpha.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15184:SF3. PTHR15184:SF3. 1 hit.
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
PIRSFiPIRSF039088. F_ATPase_subunit_alpha. 1 hit.
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00962. atpA. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATPA_THEMA
AccessioniPrimary (citable) accession number: Q9X1U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.