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Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.UniRule annotation1 Publication

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.UniRule annotation1 Publication

Kineticsi

  1. KM=0.02 mM for 2-deoxy-D-ribose 5-phosphate1 Publication

    pH dependencei

    Optimum pH is 6.5 for 2-deoxy-D-ribose 5-phosphate cleavage.1 Publication

    Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

    This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation
    Proteins known to be involved in the 2 steps of the subpathway in this organism are:
    1. no protein annotated in this organism
    2. Deoxyribose-phosphate aldolase (deoC), Deoxyribose-phosphate aldolase (deoC)
    This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Active sitei117Proton donor/acceptorUniRule annotation1
    Active sitei179Schiff-base intermediate with acetaldehydeUniRule annotation1
    Active sitei208Proton donor/acceptorUniRule annotation1

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Molecular functionLyase
    LigandSchiff base

    Enzyme and pathway databases

    UniPathwayiUPA00002; UER00468

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyribose-phosphate aldolaseUniRule annotation (EC:4.1.2.4UniRule annotation1 Publication)
    Short name:
    DERA1 PublicationUniRule annotation
    Alternative name(s):
    2-deoxy-D-ribose 5-phosphate aldolase1 PublicationUniRule annotation
    PhosphodeoxyriboaldolaseUniRule annotation
    Short name:
    DeoxyriboaldolaseUniRule annotation
    Gene namesi
    Name:deoCUniRule annotation
    Ordered Locus Names:TM_1559
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    Proteomesi
    • UP000008183 Componenti: Chromosome

    Subcellular locationi

    • Cytoplasm UniRule annotation

    GO - Cellular componenti

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000572801 – 248Deoxyribose-phosphate aldolaseAdd BLAST248

    Interactioni

    Protein-protein interaction databases

    STRINGi243274.TM1559

    Structurei

    Secondary structure

    1248
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Helixi1 – 16Combined sources16
    Beta strandi22 – 24Combined sources3
    Helixi28 – 34Combined sources7
    Beta strandi35 – 39Combined sources5
    Helixi46 – 58Combined sources13
    Beta strandi62 – 66Combined sources5
    Helixi68 – 70Combined sources3
    Helixi71 – 78Combined sources8
    Beta strandi84 – 90Combined sources7
    Turni91 – 93Combined sources3
    Helixi98 – 111Combined sources14
    Beta strandi114 – 119Combined sources6
    Helixi122 – 126Combined sources5
    Helixi130 – 143Combined sources14
    Turni144 – 146Combined sources3
    Beta strandi147 – 152Combined sources6
    Helixi155 – 157Combined sources3
    Helixi160 – 172Combined sources13
    Beta strandi176 – 179Combined sources4
    Beta strandi183 – 186Combined sources4
    Helixi191 – 201Combined sources11
    Beta strandi205 – 212Combined sources8
    Helixi216 – 224Combined sources9
    Beta strandi228 – 233Combined sources6
    Helixi235 – 246Combined sources12

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3R12X-ray1.75A/B1-248[»]
    3R13X-ray1.83A/B1-248[»]
    ProteinModelPortaliQ9X1P5
    SMRiQ9X1P5
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9X1P5

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.UniRule annotationCurated

    Phylogenomic databases

    eggNOGiENOG4105FCI Bacteria
    COG0274 LUCA
    InParanoidiQ9X1P5
    KOiK01619
    OMAiMNACIPP

    Family and domain databases

    CDDicd00959 DeoC, 1 hit
    Gene3Di3.20.20.70, 1 hit
    HAMAPiMF_00114 DeoC_type1, 1 hit
    InterProiView protein in InterPro
    IPR013785 Aldolase_TIM
    IPR011343 DeoC
    IPR002915 DeoC/FbaB/lacD_aldolase
    IPR028581 DeoC_typeI
    PANTHERiPTHR10889 PTHR10889, 1 hit
    PTHR10889:SF1 PTHR10889:SF1, 1 hit
    PfamiView protein in Pfam
    PF01791 DeoC, 1 hit
    PIRSFiPIRSF001357 DeoC, 1 hit
    SMARTiView protein in SMART
    SM01133 DeoC, 1 hit
    TIGRFAMsiTIGR00126 deoC, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q9X1P5-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MIEYRIEEAV AKYREFYEFK PVRESAGIED VKSAIEHTNL KPFATPDDIK
    60 70 80 90 100
    KLCLEARENR FHGVCVNPCY VKLAREELEG TDVKVVTVVG FPLGANETRT
    110 120 130 140 150
    KAHEAIFAVE SGADEIDMVI NVGMLKAKEW EYVYEDIRSV VESVKGKVVK
    160 170 180 190 200
    VIIETCYLDT EEKIAACVIS KLAGAHFVKT STGFGTGGAT AEDVHLMKWI
    210 220 230 240
    VGDEMGVKAS GGIRTFEDAV KMIMYGADRI GTSSGVKIVQ GGEERYGG
    Length:248
    Mass (Da):27,285
    Last modified:November 1, 1999 - v1
    Checksum:i7236D2ECA2CA1951
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AE000512 Genomic DNA Translation: AAD36625.1
    PIRiB72240
    RefSeqiNP_229359.1, NC_000853.1
    WP_004081965.1, NZ_CP011107.1

    Genome annotation databases

    EnsemblBacteriaiAAD36625; AAD36625; TM_1559
    GeneIDi897566
    KEGGitma:TM1559

    Similar proteinsi

    Entry informationi

    Entry nameiDEOC_THEMA
    AccessioniPrimary (citable) accession number: Q9X1P5
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: March 28, 2018
    This is version 131 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

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