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Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.By similarity

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.

Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyribose-phosphate aldolase (deoC), Deoxyribose-phosphate aldolase (deoC)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei179 – 1791Schiff-base intermediate with acetaldehydeBy similarity
Active sitei208 – 2081By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolase (EC:4.1.2.4)
Short name:
DERA
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name:
Deoxyriboaldolase
Gene namesi
Name:deoC
Ordered Locus Names:TM_1559
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Deoxyribose-phosphate aldolasePRO_0000057280Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1559.

Structurei

Secondary structure

248
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 1616Combined sources
Beta strandi22 – 243Combined sources
Helixi28 – 347Combined sources
Beta strandi35 – 395Combined sources
Helixi46 – 5813Combined sources
Beta strandi62 – 665Combined sources
Helixi68 – 703Combined sources
Helixi71 – 788Combined sources
Beta strandi84 – 907Combined sources
Turni91 – 933Combined sources
Helixi98 – 11114Combined sources
Beta strandi114 – 1196Combined sources
Helixi122 – 1265Combined sources
Helixi130 – 14314Combined sources
Turni144 – 1463Combined sources
Beta strandi147 – 1526Combined sources
Helixi155 – 1573Combined sources
Helixi160 – 17213Combined sources
Beta strandi176 – 1794Combined sources
Beta strandi183 – 1864Combined sources
Helixi191 – 20111Combined sources
Beta strandi205 – 2128Combined sources
Helixi216 – 2249Combined sources
Beta strandi228 – 2336Combined sources
Helixi235 – 24612Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R12X-ray1.75A/B1-248[»]
3R13X-ray1.83A/B1-248[»]
ProteinModelPortaliQ9X1P5.
SMRiQ9X1P5. Positions 1-247.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X1P5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105FCI. Bacteria.
COG0274. LUCA.
InParanoidiQ9X1P5.
KOiK01619.
OMAiFFSVCVN.

Family and domain databases

CDDicd00959. DeoC. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00126. deoC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X1P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEYRIEEAV AKYREFYEFK PVRESAGIED VKSAIEHTNL KPFATPDDIK
60 70 80 90 100
KLCLEARENR FHGVCVNPCY VKLAREELEG TDVKVVTVVG FPLGANETRT
110 120 130 140 150
KAHEAIFAVE SGADEIDMVI NVGMLKAKEW EYVYEDIRSV VESVKGKVVK
160 170 180 190 200
VIIETCYLDT EEKIAACVIS KLAGAHFVKT STGFGTGGAT AEDVHLMKWI
210 220 230 240
VGDEMGVKAS GGIRTFEDAV KMIMYGADRI GTSSGVKIVQ GGEERYGG
Length:248
Mass (Da):27,285
Last modified:November 1, 1999 - v1
Checksum:i7236D2ECA2CA1951
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36625.1.
PIRiB72240.
RefSeqiNP_229359.1. NC_000853.1.
WP_004081965.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36625; AAD36625; TM_1559.
GeneIDi897566.
KEGGitma:TM1559.
tmi:THEMA_06485.
tmw:THMA_1594.
PATRICi23938080. VBITheMar51294_1577.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36625.1.
PIRiB72240.
RefSeqiNP_229359.1. NC_000853.1.
WP_004081965.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R12X-ray1.75A/B1-248[»]
3R13X-ray1.83A/B1-248[»]
ProteinModelPortaliQ9X1P5.
SMRiQ9X1P5. Positions 1-247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1559.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36625; AAD36625; TM_1559.
GeneIDi897566.
KEGGitma:TM1559.
tmi:THEMA_06485.
tmw:THMA_1594.
PATRICi23938080. VBITheMar51294_1577.

Phylogenomic databases

eggNOGiENOG4105FCI. Bacteria.
COG0274. LUCA.
InParanoidiQ9X1P5.
KOiK01619.
OMAiFFSVCVN.

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.

Miscellaneous databases

EvolutionaryTraceiQ9X1P5.

Family and domain databases

CDDicd00959. DeoC. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00126. deoC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDEOC_THEMA
AccessioniPrimary (citable) accession number: Q9X1P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.