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Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.By similarity

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.

Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyribose-phosphate aldolase (deoC), Deoxyribose-phosphate aldolase (deoC)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei179Schiff-base intermediate with acetaldehydeBy similarity1
Active sitei208By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolase (EC:4.1.2.4)
Short name:
DERA
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name:
Deoxyriboaldolase
Gene namesi
Name:deoC
Ordered Locus Names:TM_1559
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000572801 – 248Deoxyribose-phosphate aldolaseAdd BLAST248

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1559.

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 16Combined sources16
Beta strandi22 – 24Combined sources3
Helixi28 – 34Combined sources7
Beta strandi35 – 39Combined sources5
Helixi46 – 58Combined sources13
Beta strandi62 – 66Combined sources5
Helixi68 – 70Combined sources3
Helixi71 – 78Combined sources8
Beta strandi84 – 90Combined sources7
Turni91 – 93Combined sources3
Helixi98 – 111Combined sources14
Beta strandi114 – 119Combined sources6
Helixi122 – 126Combined sources5
Helixi130 – 143Combined sources14
Turni144 – 146Combined sources3
Beta strandi147 – 152Combined sources6
Helixi155 – 157Combined sources3
Helixi160 – 172Combined sources13
Beta strandi176 – 179Combined sources4
Beta strandi183 – 186Combined sources4
Helixi191 – 201Combined sources11
Beta strandi205 – 212Combined sources8
Helixi216 – 224Combined sources9
Beta strandi228 – 233Combined sources6
Helixi235 – 246Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3R12X-ray1.75A/B1-248[»]
3R13X-ray1.83A/B1-248[»]
ProteinModelPortaliQ9X1P5.
SMRiQ9X1P5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X1P5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105FCI. Bacteria.
COG0274. LUCA.
InParanoidiQ9X1P5.
KOiK01619.
OMAiFFSVCVN.

Family and domain databases

CDDicd00959. DeoC. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00126. deoC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X1P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEYRIEEAV AKYREFYEFK PVRESAGIED VKSAIEHTNL KPFATPDDIK
60 70 80 90 100
KLCLEARENR FHGVCVNPCY VKLAREELEG TDVKVVTVVG FPLGANETRT
110 120 130 140 150
KAHEAIFAVE SGADEIDMVI NVGMLKAKEW EYVYEDIRSV VESVKGKVVK
160 170 180 190 200
VIIETCYLDT EEKIAACVIS KLAGAHFVKT STGFGTGGAT AEDVHLMKWI
210 220 230 240
VGDEMGVKAS GGIRTFEDAV KMIMYGADRI GTSSGVKIVQ GGEERYGG
Length:248
Mass (Da):27,285
Last modified:November 1, 1999 - v1
Checksum:i7236D2ECA2CA1951
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36625.1.
PIRiB72240.
RefSeqiNP_229359.1. NC_000853.1.
WP_004081965.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36625; AAD36625; TM_1559.
GeneIDi897566.
KEGGitma:TM1559.
PATRICi23938080. VBITheMar51294_1577.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36625.1.
PIRiB72240.
RefSeqiNP_229359.1. NC_000853.1.
WP_004081965.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3R12X-ray1.75A/B1-248[»]
3R13X-ray1.83A/B1-248[»]
ProteinModelPortaliQ9X1P5.
SMRiQ9X1P5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1559.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36625; AAD36625; TM_1559.
GeneIDi897566.
KEGGitma:TM1559.
PATRICi23938080. VBITheMar51294_1577.

Phylogenomic databases

eggNOGiENOG4105FCI. Bacteria.
COG0274. LUCA.
InParanoidiQ9X1P5.
KOiK01619.
OMAiFFSVCVN.

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.

Miscellaneous databases

EvolutionaryTraceiQ9X1P5.

Family and domain databases

CDDicd00959. DeoC. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00126. deoC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDEOC_THEMA
AccessioniPrimary (citable) accession number: Q9X1P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.