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Protein

FAD:protein FMN transferase

Gene

TM_1553

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.UniRule annotation

Catalytic activityi

FAD + [protein]-L-threonine = [protein]-FMN-L-threonine + AMP.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Magnesium. Can also use manganese.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi191 – 1911Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi303 – 3031MagnesiumUniRule annotation
Metal bindingi307 – 3071MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-1594-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
FAD:protein FMN transferaseUniRule annotation (EC:2.7.1.180UniRule annotation)
Gene namesi
Ordered Locus Names:TM_1553Imported
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Imported
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 3920HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1553.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VRMX-ray1.58A40-352[»]
ProteinModelPortaliQ9X1N9.
SMRiQ9X1N9. Positions 44-352.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X1N9.

Family & Domainsi

Sequence similaritiesi

Belongs to the ApbE family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105CJ2. Bacteria.
COG1477. LUCA.
InParanoidiQ9X1N9.
KOiK03734.
OMAiLELWGFT.

Family and domain databases

InterProiIPR024932. ApbE.
IPR003374. ApbE-like.
[Graphical view]
PANTHERiPTHR30040:SF2. PTHR30040:SF2. 1 hit.
PfamiPF02424. ApbE. 1 hit.
[Graphical view]
PIRSFiPIRSF006268. ApbE. 1 hit.
SUPFAMiSSF143631. SSF143631. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X1N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKMWPSDSN DHRVTRRNVI IFSSLLLGSL AILLALLLIR TKDQYYELRD
60 70 80 90 100
FALGTSVRIV VSSQKINPRT IAEAILEDMK RITYKFSFTD ERSVVKKIND
110 120 130 140 150
HPNEWVEVDE ETYSLIKAAC AFAELTDGAF DPTVGRLLEL WGFTGNYENL
160 170 180 190 200
RVPSREEIEE ALKHTGYKNV LFDDKNMRVM VKNGVKIDLG GIAKGYALDR
210 220 230 240 250
ARQIALSFDE NATGFVEAGG DVRIIGPKFG KYPWVIGVKD PRGDDVIDYI
260 270 280 290 300
YLKSGAVATS GDYERYFVVD GVRYHHILDP STGYPARGVW SVTIIAEDAT
310 320 330 340 350
TADALSTAGF VMAGKDWRKV VLDFPNMGAH LLIVLEGGAI ERSETFKLFE

RE
Length:352
Mass (Da):39,542
Last modified:November 1, 1999 - v1
Checksum:i5A6DEE3F4653A0A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36619.1.
PIRiD72239.
RefSeqiNP_229353.1. NC_000853.1.
WP_010865358.1. NC_000853.1.

Genome annotation databases

EnsemblBacteriaiAAD36619; AAD36619; TM_1553.
GeneIDi897605.
KEGGitma:TM1553.
PATRICi23938068. VBITheMar51294_1571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36619.1.
PIRiD72239.
RefSeqiNP_229353.1. NC_000853.1.
WP_010865358.1. NC_000853.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VRMX-ray1.58A40-352[»]
ProteinModelPortaliQ9X1N9.
SMRiQ9X1N9. Positions 44-352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1553.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36619; AAD36619; TM_1553.
GeneIDi897605.
KEGGitma:TM1553.
PATRICi23938068. VBITheMar51294_1571.

Phylogenomic databases

eggNOGiENOG4105CJ2. Bacteria.
COG1477. LUCA.
InParanoidiQ9X1N9.
KOiK03734.
OMAiLELWGFT.

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-1594-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9X1N9.

Family and domain databases

InterProiIPR024932. ApbE.
IPR003374. ApbE-like.
[Graphical view]
PANTHERiPTHR30040:SF2. PTHR30040:SF2. 1 hit.
PfamiPF02424. ApbE. 1 hit.
[Graphical view]
PIRSFiPIRSF006268. ApbE. 1 hit.
SUPFAMiSSF143631. SSF143631. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9X1N9_THEMA
AccessioniPrimary (citable) accession number: Q9X1N9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.