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Protein

FAD:protein FMN transferase

Gene

TM_1553

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.UniRule annotation

Catalytic activityi

FAD + [protein]-L-threonine = [protein]-FMN-L-threonine + AMP.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Magnesium. Can also use manganese.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi191Magnesium; via carbonyl oxygenUniRule annotation1
Binding sitei194FADUniRule annotation1
Binding sitei276FADUniRule annotation1
Binding sitei278FADUniRule annotation1
Metal bindingi303MagnesiumUniRule annotation1
Metal bindingi307MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi129 – 131FADUniRule annotation3
Nucleotide bindingi188 – 190FADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein, MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciTMAR243274:G1H0Q-1304-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
FAD:protein FMN transferaseUniRule annotation (EC:2.7.1.180UniRule annotation)
Alternative name(s):
Flavin transferaseUniRule annotation
Gene namesi
Ordered Locus Names:TM_1553Imported
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Imported
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 39HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1553

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VRMX-ray1.58A40-352[»]
ProteinModelPortaliQ9X1N9
SMRiQ9X1N9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X1N9

Family & Domainsi

Sequence similaritiesi

Belongs to the ApbE family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105CJ2 Bacteria
COG1477 LUCA
InParanoidiQ9X1N9
KOiK03734
OMAiMGTFWRV

Family and domain databases

InterProiView protein in InterPro
IPR024932 ApbE
IPR003374 ApbE-like_sf
PANTHERiPTHR30040 PTHR30040, 1 hit
PfamiView protein in Pfam
PF02424 ApbE, 1 hit
PIRSFiPIRSF006268 ApbE, 1 hit
SUPFAMiSSF143631 SSF143631, 1 hit

Sequencei

Sequence statusi: Complete.

Q9X1N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKMWPSDSN DHRVTRRNVI IFSSLLLGSL AILLALLLIR TKDQYYELRD
60 70 80 90 100
FALGTSVRIV VSSQKINPRT IAEAILEDMK RITYKFSFTD ERSVVKKIND
110 120 130 140 150
HPNEWVEVDE ETYSLIKAAC AFAELTDGAF DPTVGRLLEL WGFTGNYENL
160 170 180 190 200
RVPSREEIEE ALKHTGYKNV LFDDKNMRVM VKNGVKIDLG GIAKGYALDR
210 220 230 240 250
ARQIALSFDE NATGFVEAGG DVRIIGPKFG KYPWVIGVKD PRGDDVIDYI
260 270 280 290 300
YLKSGAVATS GDYERYFVVD GVRYHHILDP STGYPARGVW SVTIIAEDAT
310 320 330 340 350
TADALSTAGF VMAGKDWRKV VLDFPNMGAH LLIVLEGGAI ERSETFKLFE

RE
Length:352
Mass (Da):39,542
Last modified:November 1, 1999 - v1
Checksum:i5A6DEE3F4653A0A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA Translation: AAD36619.1
PIRiD72239
RefSeqiNP_229353.1, NC_000853.1
WP_010865358.1, NZ_CP011107.1

Genome annotation databases

EnsemblBacteriaiAAD36619; AAD36619; TM_1553
GeneIDi897605
KEGGitma:TM1553
PATRICifig|243274.5.peg.1571

Similar proteinsi

Entry informationi

Entry nameiQ9X1N9_THEMA
AccessioniPrimary (citable) accession number: Q9X1N9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

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