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Q9X1K8 (DAPB_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26
Gene names
Name:dapB
Ordered Locus Names:TM_1520
OrganismThermotoga maritima
Taxonomic identifier2336 [NCBI]
Taxonomic lineageBacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102

Subcellular location

Cytoplasm By similarity HAMAP MF_00102.

Sequence similarities

Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNADPH binding

Inferred from electronic annotation. Source: InterPro

dihydrodipicolinate reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 216216Dihydrodipicolinate reductase HAMAP MF_00102
PRO_0000141502

Secondary structure

1 ....................................... 216
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9X1K8 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 2C5670DF62C85528

FASTA21623,731
        10         20         30         40         50         60 
MKYGIVGYSG RMGQEIQKVF SEKGHELVLK VDVNGVEELD SPDVVIDFSS PEALPKTVDL 

        70         80         90        100        110        120 
CKKYRAGLVL GTTALKEEHL QMLRELSKEV PVVQAYNFSI GINVLKRFLS ELVKVLEDWD 

       130        140        150        160        170        180 
VEIVETHHRF KKDAPSGTAI LLESALGKSV PIHSLRVGGV PGDHVVVFGN IGETIEIKHR 

       190        200        210 
AISRTVFAIG ALKAAEFLVG KDPGMYSFEE VIFGGE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000512 Genomic DNA. Translation: AAD36587.1.
PIRA72246.
RefSeqNP_229320.1. NC_000853.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1VM6X-ray2.27A/B/C/D1-216[»]
ProteinModelPortalQ9X1K8.
SMRQ9X1K8. Positions 1-215.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID897986.
GenomeReviewsGene locus TM_1520 in contig AE000512_GR.
KEGGtma:TM1520.
NMPDRfig|243274.1.peg.1504.
PATRIC23937998. VBITheMar51294_1537.
TIGRTM_1520.

Phylogenomic databases

HOGENOMHBG594002.
OMAMVRVILN.
PhylomeDBQ9X1K8.
ProtClustDBCLSK875808.

Enzyme and pathway databases

BioCycTMAR243274:TM_1520-MONOMER.

Family and domain databases

HAMAPMF_00102. DapB.
[Tree]
InterProIPR022663. DapB_C.
IPR000846. DapB_N.
IPR022664. DapB_N_CS.
IPR011770. Dihydrodipicolinate_Rdtase.
IPR023940. Dihydrodipicolinate_Rdtase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00215.
PANTHERPTHR20836. DapB_bac/pln. 1 hit.
PfamPF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view]
PIRSFPIRSF000161. DHPR. 1 hit.
PROSITEPS01298. DAPB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_THEMA
AccessionPrimary (citable) accession number: Q9X1K8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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