Reviewed, UniProtKB/Swiss-Prot Q9X1J7 (Y1509_THEMA)

Names and origin

Protein names

Recommended name:
    Putative metalloprotease TM_1509
    EC=3.4.24.-

Gene names

Ordered Locus Names:

TM_1509

Organism

Thermotoga maritima [Complete proteome] [HAMAP]

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	150 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May have metalloprotease activity Potential. Ref.2
Cofactor	Binds 1 zinc ion. HAMAP MF_00009
Sequence similarities	Belongs to the UPF0054 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Molecular function	metallopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 150

150

Putative metalloprotease TM_1509 HAMAP MF_00009

PRO_0000102553

Sites

Metal binding

102

1

Zinc; catalytic By similarity

Metal binding

106

1

Zinc; catalytic By similarity

Metal binding

112

1

Zinc; catalytic By similarity

Secondary structure

1

.

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.

.

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.

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.

.

.

.

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.

.

.

150

Helix Strand Turn

Details...

Beta strand

3 – 6

4

Helix

11 – 16

6

Helix

18 – 28

11

Beta strand

35 – 38

4

Helix

41 – 49

9

Beta strand

59 – 61

3

Beta strand

67 – 69

3

Beta strand

72 – 76

5

Helix

78 – 87

10

Helix

92 – 108

17

Helix

120 – 137

18

Sequences

	Sequence		Length	Mass (Da)
	Q9X1J7-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 5BDE227C0BE6DCC5	FASTA	150	17,550
	10 20 30 40 50 60 MIRILGEGKG SKLLENLKEK LEEIVKKEIG DVHVNVILVS EDEIKELNQQ FRGQDRPTDV 70 80 90 100 110 120 LTFPLMEEDV YGEIYVCPLI VEENAREFNN TFEKELLEVV IHGILHLAGY DHEFEDKNSK 130 140 150 EMFEKQKKYV EEVWGEWRSN PSEDSDPGKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
[2]	"NMR solution structure of Thermotoga maritima protein TM1509 reveals a Zn-metalloprotease-like tertiary structure." Penhoat C.H., Li Z., Atreya H.S., Kim S., Yee A., Xiao R., Murray D., Arrowsmith C.H., Szyperski T. J. Struct. Funct. Genomics 6:51-62(2005) [PubMed: 15965736] [Abstract] Cited for: STRUCTURE BY NMR, FUNCTION, ZINC BINDING.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000512 Genomic DNA. Translation: AAD36576.1.

PIR

F72244.

RefSeq

NP_229309.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1TVI	NMR	-	A	1-150	[»]

ModBase

Search...

Genome annotation databases

GeneID

898186.

GenomeReviews

Gene locus TM_1509 in contig AE000512_GR.

KEGG

tma:TM1509.

NMPDR

fig|243274.1.peg.1493.

TIGR

TM_1509.

Phylogenomic databases

HOGENOM

HBG734136.

OMA

LMEEDVY.

Enzyme and pathway databases

BioCyc

TMAR243274:TM_1509-MONOMER.

Family and domain databases

HAMAP

MF_00009. UPF0054.
[Tree]

InterPro

IPR002036. UPF0054.
IPR020549. UPF0054_CS.
[Graphical view]

Pfam

PF02130. UPF0054. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00043. UPF0054. 1 hit.

PROSITE

PS01306. UPF0054. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Y1509_THEMA

Accession

Primary (citable) accession number: Q9X1J7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	February 9, 2010
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)