Unreviewed, UniProtKB/TrEMBL Q9X1I7 (Q9X1I7_THEMA)

Names and origin

Protein names

Recommended name:
    Methionine aminopeptidase RuleBase RU003653V0
    EC=3.4.11.18

Gene names

Ordered Locus Names:

TM_1478

Organism

Thermotoga maritima [Complete proteome] [HAMAP]

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Removes the amino-terminal methionine from nascent proteins By similarity. RuleBase RU003653V0
Catalytic activity	Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. RuleBase RU003653V0
Cofactor	Binds 2 cobalt ions per subunit By similarity. RuleBase RU003653V0
Sequence similarities	Belongs to the peptidase M24A family. RuleBase RU003653V0

Ontologies

Keywords
Ligand	Cobalt RuleBase RU003653V0 Metal-binding RuleBase RU003653V0
Molecular function	Aminopeptidase RuleBase RU003653V0 EMBL AAD36544.1 Hydrolase Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW cobalt ion binding Inferred from electronic annotation. Source: UniProtKB-KW metalloexopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9X1I7-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: B259C59CC1B66E29	FASTA	250	27,489
	10 20 30 40 50 60 MIRIKTPSEI EKMKKAGKAV AVALREVRKV IVPGKTAWDV ETLVLEIFKK LRVKPAFKGY 70 80 90 100 110 120 GGYKYATCVS VNEEVVHGLP LKEKVFKEGD IVSVDVGAVY QGLYGDAAVT YIVGETDERG 130 140 150 160 170 180 KELVRVTREV LEKAIKMIKP GIRLGDVSHC IQETVESVGF NVIRDYVGHG VGRELHEDPQ 190 200 210 220 230 240 IPNYGTPGTG VVLRKGMTLA IEPMVSEGDW RVVVKEDGWT AVTVDGSRCA HFEHTILITE 250 NGAEILTKEG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
[2]	"Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1.9 A resolution." Spraggon G., Schwarzenbacher R., Kreusch A., McMullan D., Brinen L.S., Canaves J.M., Dai X., Deacon A.M., Elsliger M.A., Eshagi S., Floyd R., Godzik A., Grittini C., Grzechnik S.K., Jaroszewski L., Karlak C., Klock H.E., Koesema E. , Kovarik J.S., Kuhn P., McPhillips T.M., Miller M.D., Morse A., Moy K., Ouyang J., Page R., Quijano K., Rezezadeh F., Robb A., Sims E., Stevens R.C., van den Bedem H., Velasquez J., Vincent J., von Delft F., Wang X., West B., Wolf G., Xu Q., Hodgson K.O., Wooley J., Lesley S.A., Wilson I.A. Proteins 56:396-400(2004) [PubMed: 15211524] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).

Cross-references

Sequence databases

EMBLGenBankDDBJ

AE000512 Genomic DNA. Translation: AAD36544.1.

PIR

F72247.

RefSeq

NP_229278.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1O0X	X-ray	1.90	A	1-250	[»]

ModBase

Search...

Protein family/group databases

MEROPS

M24.001.

Genome annotation databases

GeneID

898008.

GenomeReviews

Gene locus TM_1478 in contig AE000512_GR.

KEGG

tma:TM1478.

NMPDR

fig|243274.1.peg.1462.

TIGR

TM_1478.

Phylogenomic databases

HOGENOM

Q9X1I7.

OMA

TATGPRI

Enzyme and pathway databases

BioCyc

TMAR243274:TM_1478-MON.

Family and domain databases

InterPro

IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002467. Pept_M24A_MAP1.
[Graphical view]

Gene3D

G3DSA:3.90.230.10. Peptidase_M24_cat_core. 1 hit.

PANTHER

PTHR10804:SF13. Pept_M24A_MAP1. 1 hit.
PTHR10804. Peptidase_M24_cat_core. 1 hit.

Pfam

PF00557. Peptidase_M24. 1 hit.
[Graphical view]

PRINTS

PR00599. MAPEPTIDASE.

TIGRFAMs

TIGR00500. met_pdase_I. 1 hit.

PROSITE

PS00680. MAP_1. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q9X1I7_THEMA

Accession

Primary (citable) accession number: Q9X1I7

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	November 3, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)