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Q9X1H4

- RNPA_THEMA

UniProt

Q9X1H4 - RNPA_THEMA

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Protein

Ribonuclease P protein component

Gene

rnpA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

GO - Molecular functioni

  1. ribonuclease P activity Source: UniProtKB-EC
  2. tRNA binding Source: InterPro

GO - Biological processi

  1. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein componentUniRule annotation (EC:3.1.26.5UniRule annotation)
Short name:
RNase P proteinUniRule annotation
Short name:
RNaseP proteinUniRule annotation
Alternative name(s):
Protein C5UniRule annotation
Gene namesi
Name:rnpAUniRule annotation
Ordered Locus Names:TM_1463
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 117117Ribonuclease P protein componentPRO_0000198555Add
BLAST

Interactioni

Subunit structurei

Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.UniRule annotation

Protein-protein interaction databases

STRINGi243274.TM1463.

Structurei

Secondary structure

1
117
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi13 – 2311Combined sources
Beta strandi24 – 285Combined sources
Beta strandi30 – 389Combined sources
Beta strandi40 – 434Combined sources
Beta strandi45 – 484Combined sources
Helixi52 – 543Combined sources
Helixi57 – 7418Combined sources
Turni75 – 773Combined sources
Beta strandi80 – 889Combined sources
Helixi90 – 956Combined sources
Helixi96 – 983Combined sources
Helixi101 – 11212Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NZ0X-ray1.20A/B/C/D1-117[»]
3Q1QX-ray3.80A3-117[»]
3Q1RX-ray4.21A3-117[»]
ProteinModelPortaliQ9X1H4.
SMRiQ9X1H4. Positions 11-117.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X1H4.

Family & Domainsi

Sequence similaritiesi

Belongs to the RnpA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0594.
InParanoidiQ9X1H4.
KOiK03536.
OMAiMTESFTR.
OrthoDBiEOG6C01C6.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
HAMAPiMF_00227. RNase_P.
InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR000100. RNase_P.
IPR020539. RNase_P_CS.
[Graphical view]
PfamiPF00825. Ribonuclease_P. 1 hit.
[Graphical view]
ProDomiPD003629. Ribonuclease_P. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR00188. rnpA. 1 hit.
PROSITEiPS00648. RIBONUCLEASE_P. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X1H4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTESFTRRER LRLRRDFLLI FKEGKSLQNE YFVVLFRKNG LDYSRLGIVV
60 70 80 90 100
KRKFGKATRR NKLKRWVREI FRRNKGVIPK GFDIVVIPRK KLSEEFERVD
110
FWTVREKLLN LLKRIEG
Length:117
Mass (Da):14,317
Last modified:November 1, 1999 - v1
Checksum:i0E68A9B25D023C64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36531.1.
PIRiH72251.
RefSeqiNP_229262.1. NC_000853.1.
WP_004081756.1. NC_023151.1.
YP_007977818.1. NC_021214.1.
YP_008991448.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD36531; AAD36531; TM_1463.
GeneIDi18093247.
898016.
KEGGitma:TM1463.
PATRICi23937878. VBITheMar51294_1477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36531.1 .
PIRi H72251.
RefSeqi NP_229262.1. NC_000853.1.
WP_004081756.1. NC_023151.1.
YP_007977818.1. NC_021214.1.
YP_008991448.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1NZ0 X-ray 1.20 A/B/C/D 1-117 [» ]
3Q1Q X-ray 3.80 A 3-117 [» ]
3Q1R X-ray 4.21 A 3-117 [» ]
ProteinModelPortali Q9X1H4.
SMRi Q9X1H4. Positions 11-117.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM1463.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD36531 ; AAD36531 ; TM_1463 .
GeneIDi 18093247.
898016.
KEGGi tma:TM1463.
PATRICi 23937878. VBITheMar51294_1477.

Phylogenomic databases

eggNOGi COG0594.
InParanoidi Q9X1H4.
KOi K03536.
OMAi MTESFTR.
OrthoDBi EOG6C01C6.

Miscellaneous databases

EvolutionaryTracei Q9X1H4.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
HAMAPi MF_00227. RNase_P.
InterProi IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR000100. RNase_P.
IPR020539. RNase_P_CS.
[Graphical view ]
Pfami PF00825. Ribonuclease_P. 1 hit.
[Graphical view ]
ProDomi PD003629. Ribonuclease_P. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF54211. SSF54211. 1 hit.
TIGRFAMsi TIGR00188. rnpA. 1 hit.
PROSITEi PS00648. RIBONUCLEASE_P. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (1.2 ANGSTROMS).

Entry informationi

Entry nameiRNPA_THEMA
AccessioniPrimary (citable) accession number: Q9X1H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3