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Q9X1H4

- RNPA_THEMA

UniProt

Q9X1H4 - RNPA_THEMA

Protein

Ribonuclease P protein component

Gene

rnpA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

    GO - Molecular functioni

    1. ribonuclease P activity Source: UniProtKB-EC
    2. tRNA binding Source: InterPro

    GO - Biological processi

    1. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein componentUniRule annotation (EC:3.1.26.5UniRule annotation)
    Short name:
    RNase P proteinUniRule annotation
    Short name:
    RNaseP proteinUniRule annotation
    Alternative name(s):
    Protein C5UniRule annotation
    Gene namesi
    Name:rnpAUniRule annotation
    Ordered Locus Names:TM_1463
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 117117Ribonuclease P protein componentPRO_0000198555Add
    BLAST

    Interactioni

    Subunit structurei

    Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.UniRule annotation

    Protein-protein interaction databases

    STRINGi243274.TM1463.

    Structurei

    Secondary structure

    1
    117
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi13 – 2311
    Beta strandi24 – 285
    Beta strandi30 – 389
    Beta strandi40 – 434
    Beta strandi45 – 484
    Helixi52 – 543
    Helixi57 – 7418
    Turni75 – 773
    Beta strandi80 – 889
    Helixi90 – 956
    Helixi96 – 983
    Helixi101 – 11212

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1NZ0X-ray1.20A/B/C/D1-117[»]
    3Q1QX-ray3.80A3-117[»]
    3Q1RX-ray4.21A3-117[»]
    ProteinModelPortaliQ9X1H4.
    SMRiQ9X1H4. Positions 11-117.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9X1H4.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RnpA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0594.
    KOiK03536.
    OMAiMTESFTR.
    OrthoDBiEOG6C01C6.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    HAMAPiMF_00227. RNase_P.
    InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR000100. RNase_P.
    IPR020539. RNase_P_CS.
    [Graphical view]
    PfamiPF00825. Ribonuclease_P. 1 hit.
    [Graphical view]
    ProDomiPD003629. Ribonuclease_P. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF54211. SSF54211. 1 hit.
    TIGRFAMsiTIGR00188. rnpA. 1 hit.
    PROSITEiPS00648. RIBONUCLEASE_P. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9X1H4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTESFTRRER LRLRRDFLLI FKEGKSLQNE YFVVLFRKNG LDYSRLGIVV    50
    KRKFGKATRR NKLKRWVREI FRRNKGVIPK GFDIVVIPRK KLSEEFERVD 100
    FWTVREKLLN LLKRIEG 117
    Length:117
    Mass (Da):14,317
    Last modified:November 1, 1999 - v1
    Checksum:i0E68A9B25D023C64
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36531.1.
    PIRiH72251.
    RefSeqiNP_229262.1. NC_000853.1.
    YP_007977818.1. NC_021214.1.
    YP_008991448.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD36531; AAD36531; TM_1463.
    GeneIDi898016.
    KEGGitma:TM1463.
    tmi:THEMA_07000.
    tmm:Tmari_1469.
    PATRICi23937878. VBITheMar51294_1477.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36531.1 .
    PIRi H72251.
    RefSeqi NP_229262.1. NC_000853.1.
    YP_007977818.1. NC_021214.1.
    YP_008991448.1. NC_023151.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1NZ0 X-ray 1.20 A/B/C/D 1-117 [» ]
    3Q1Q X-ray 3.80 A 3-117 [» ]
    3Q1R X-ray 4.21 A 3-117 [» ]
    ProteinModelPortali Q9X1H4.
    SMRi Q9X1H4. Positions 11-117.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243274.TM1463.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD36531 ; AAD36531 ; TM_1463 .
    GeneIDi 898016.
    KEGGi tma:TM1463.
    tmi:THEMA_07000.
    tmm:Tmari_1469.
    PATRICi 23937878. VBITheMar51294_1477.

    Phylogenomic databases

    eggNOGi COG0594.
    KOi K03536.
    OMAi MTESFTR.
    OrthoDBi EOG6C01C6.

    Miscellaneous databases

    EvolutionaryTracei Q9X1H4.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    HAMAPi MF_00227. RNase_P.
    InterProi IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR000100. RNase_P.
    IPR020539. RNase_P_CS.
    [Graphical view ]
    Pfami PF00825. Ribonuclease_P. 1 hit.
    [Graphical view ]
    ProDomi PD003629. Ribonuclease_P. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF54211. SSF54211. 1 hit.
    TIGRFAMsi TIGR00188. rnpA. 1 hit.
    PROSITEi PS00648. RIBONUCLEASE_P. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
    2. Cited for: X-RAY CRYSTALLOGRAPHY (1.2 ANGSTROMS).

    Entry informationi

    Entry nameiRNPA_THEMA
    AccessioniPrimary (citable) accession number: Q9X1H4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3