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Q9X1E4 (GLPK2_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycerol kinase 2

EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase 2
Glycerokinase 2
Short name=GK 2
Gene names
Name:glpK2
Ordered Locus Names:TM_1430
OrganismThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [Reference proteome] [HAMAP]
Taxonomic identifier243274 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Protein attributes

Sequence length496 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate By similarity. HAMAP-Rule MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP-Rule MF_00186

Enzyme regulation

Inhibited by fructose 1,6-bisphosphate (FBP) By similarity. HAMAP-Rule MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP-Rule MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Sequence caution

The sequence AAD36500.1 differs from that shown. Reason: Erroneous termination at position 483. Translated as Trp.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 496496Glycerol kinase 2 HAMAP-Rule MF_00186
PRO_0000059514

Regions

Nucleotide binding11 – 133ATP By similarity
Nucleotide binding408 – 4125ATP By similarity
Region81 – 822Substrate binding By similarity
Region242 – 2432Substrate binding By similarity

Sites

Binding site111Substrate By similarity
Binding site151ATP By similarity
Binding site1331Substrate By similarity
Binding site2641ATP By similarity
Binding site3071ATP; via carbonyl oxygen By similarity
Binding site3111ATP; via amide nitrogen By similarity
Binding site3261ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9X1E4 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 7FA72A4CBD29E701

FASTA49655,576
        10         20         30         40         50         60 
MKYVLSLDQG TTSSRAIVFD EKGNVVSKVN KEFRQIYPRP GWVEHDPVEI WESQIEVAKK 

        70         80         90        100        110        120 
AIEEAGIKPE DIAAIGITNQ RETTIVWDKN TGKPVYNAIV WQCRRTAPIC DELKEKGYSE 

       130        140        150        160        170        180 
FIRERTGLVI DAYFSGTKIK WILDNVEGVR EKAEKGEVLF GTVDTWLIWN LTGGRVHVTD 

       190        200        210        220        230        240 
YSNASRTMIF NIHKLDWDDE ILELLNIPRA MLPQVMPSSH VYGYTAKDIF GVEIPIAGDA 

       250        260        270        280        290        300 
GDQQAALFGQ ACFQPGMLKN TYGTGCFLLM NTGEKAFESK SGLLTTIAWG INGKVYYALE 

       310        320        330        340        350        360 
GSIFITGAAV QWLRDGLKII SNAAETEELA TKVPDNGGVF FVPAFVGLGA PYWDMYARGL 

       370        380        390        400        410        420 
IIGITRGTTR EHIVRAVLES IAYQTRDVVE VMEKDSDIKV ETLRVDGGAV VNNFLMQFQA 

       430        440        450        460        470        480 
DILGVPVERP VVNETTALGA AYLAGLAVGY WKDQEEIASL WQLDRRFEPS MNSEERERLY 

       490 
SKWKEAVSRS LGWEKR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000512 Genomic DNA. Translation: AAD36500.1. Sequence problems.
PIRC72254.
RefSeqNP_229230.1. NC_000853.1.
YP_007977785.1. NC_021214.1.

3D structure databases

ProteinModelPortalQ9X1E4.
SMRQ9X1E4. Positions 2-495.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243274.TM1430.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD36500; AAD36500; TM_1430.
GeneID15495038.
898045.
KEGGtma:TM1430.
tmm:Tmari_1436.
PATRIC23937808. VBITheMar51294_1442.

Phylogenomic databases

eggNOGCOG0554.
KOK00864.
OMAALYGQLC.
OrthoDBEOG6RZB46.
ProtClustDBCLSK795900.

Enzyme and pathway databases

BioCycTMAR243274:GC6P-1468-MONOMER.
UniPathwayUPA00618; UER00672.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
InterProIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK2_THEMA
AccessionPrimary (citable) accession number: Q9X1E4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: February 19, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways