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Q9X1E4

- GLPK2_THEMA

UniProt

Q9X1E4 - GLPK2_THEMA

Protein

Glycerol kinase 2

Gene

glpK2

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

    Catalytic activityi

    ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

    Enzyme regulationi

    Inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111SubstrateUniRule annotation
    Binding sitei15 – 151ATPUniRule annotation
    Binding sitei133 – 1331SubstrateUniRule annotation
    Binding sitei264 – 2641ATPUniRule annotation
    Binding sitei307 – 3071ATP; via carbonyl oxygenUniRule annotation
    Binding sitei311 – 3111ATP; via amide nitrogenUniRule annotation
    Binding sitei326 – 3261ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 133ATPUniRule annotation
    Nucleotide bindingi408 – 4125ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glycerol kinase activity Source: UniProtKB

    GO - Biological processi

    1. glycerol-3-phosphate metabolic process Source: UniProtKB-HAMAP
    2. glycerol catabolic process Source: UniProtKB-UniPathway
    3. glycerol metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycerol metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTMAR243274:GC6P-1468-MONOMER.
    UniPathwayiUPA00618; UER00672.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol kinase 2UniRule annotation (EC:2.7.1.30UniRule annotation)
    Alternative name(s):
    ATP:glycerol 3-phosphotransferase 2UniRule annotation
    Glycerokinase 2UniRule annotation
    Short name:
    GK 2UniRule annotation
    Gene namesi
    Name:glpK2UniRule annotation
    Ordered Locus Names:TM_1430
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Glycerol kinase 2PRO_0000059514Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243274.TM1430.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9X1E4.
    SMRiQ9X1E4. Positions 2-495.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni81 – 822Substrate bindingUniRule annotation
    Regioni242 – 2432Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the FGGY kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0554.
    KOiK00864.
    OMAiHFFGVEV.
    OrthoDBiEOG6RZB46.

    Family and domain databases

    HAMAPiMF_00186. Glycerol_kin.
    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
    PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9X1E4-1 [UniParc]FASTAAdd to Basket

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    MKYVLSLDQG TTSSRAIVFD EKGNVVSKVN KEFRQIYPRP GWVEHDPVEI    50
    WESQIEVAKK AIEEAGIKPE DIAAIGITNQ RETTIVWDKN TGKPVYNAIV 100
    WQCRRTAPIC DELKEKGYSE FIRERTGLVI DAYFSGTKIK WILDNVEGVR 150
    EKAEKGEVLF GTVDTWLIWN LTGGRVHVTD YSNASRTMIF NIHKLDWDDE 200
    ILELLNIPRA MLPQVMPSSH VYGYTAKDIF GVEIPIAGDA GDQQAALFGQ 250
    ACFQPGMLKN TYGTGCFLLM NTGEKAFESK SGLLTTIAWG INGKVYYALE 300
    GSIFITGAAV QWLRDGLKII SNAAETEELA TKVPDNGGVF FVPAFVGLGA 350
    PYWDMYARGL IIGITRGTTR EHIVRAVLES IAYQTRDVVE VMEKDSDIKV 400
    ETLRVDGGAV VNNFLMQFQA DILGVPVERP VVNETTALGA AYLAGLAVGY 450
    WKDQEEIASL WQLDRRFEPS MNSEERERLY SKWKEAVSRS LGWEKR 496
    Length:496
    Mass (Da):55,576
    Last modified:May 30, 2000 - v2
    Checksum:i7FA72A4CBD29E701
    GO

    Sequence cautioni

    The sequence AAD36500.1 differs from that shown. Reason: Erroneous termination at position 483. Translated as Trp.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36500.1. Sequence problems.
    PIRiC72254.
    RefSeqiNP_229230.1. NC_000853.1.
    YP_007977785.1. NC_021214.1.

    Genome annotation databases

    EnsemblBacteriaiAAD36500; AAD36500; TM_1430.
    GeneIDi898045.
    KEGGitma:TM1430.
    tmm:Tmari_1436.
    PATRICi23937808. VBITheMar51294_1442.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36500.1 . Sequence problems.
    PIRi C72254.
    RefSeqi NP_229230.1. NC_000853.1.
    YP_007977785.1. NC_021214.1.

    3D structure databases

    ProteinModelPortali Q9X1E4.
    SMRi Q9X1E4. Positions 2-495.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243274.TM1430.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD36500 ; AAD36500 ; TM_1430 .
    GeneIDi 898045.
    KEGGi tma:TM1430.
    tmm:Tmari_1436.
    PATRICi 23937808. VBITheMar51294_1442.

    Phylogenomic databases

    eggNOGi COG0554.
    KOi K00864.
    OMAi HFFGVEV.
    OrthoDBi EOG6RZB46.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00672 .
    BioCyci TMAR243274:GC6P-1468-MONOMER.

    Family and domain databases

    HAMAPi MF_00186. Glycerol_kin.
    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
    PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

    Entry informationi

    Entry nameiGLPK2_THEMA
    AccessioniPrimary (citable) accession number: Q9X1E4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3