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Q9X1E4

- GLPK2_THEMA

UniProt

Q9X1E4 - GLPK2_THEMA

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Protein
Glycerol kinase 2
Gene
glpK2, TM_1430
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate By similarity.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

Enzyme regulationi

Inhibited by fructose 1,6-bisphosphate (FBP) By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Substrate By similarity
Binding sitei15 – 151ATP By similarity
Binding sitei133 – 1331Substrate By similarity
Binding sitei264 – 2641ATP By similarity
Binding sitei307 – 3071ATP; via carbonyl oxygen By similarity
Binding sitei311 – 3111ATP; via amide nitrogen By similarity
Binding sitei326 – 3261ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 133ATP By similarity
Nucleotide bindingi408 – 4125ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glycerol kinase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. glycerol catabolic process Source: UniProtKB-UniPathway
  2. glycerol metabolic process Source: UniProtKB
  3. glycerol-3-phosphate metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-1468-MONOMER.
UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinase 2 (EC:2.7.1.30)
Alternative name(s):
ATP:glycerol 3-phosphotransferase 2
Glycerokinase 2
Short name:
GK 2
Gene namesi
Name:glpK2
Ordered Locus Names:TM_1430
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Glycerol kinase 2UniRule annotation
PRO_0000059514Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1430.

Structurei

3D structure databases

ProteinModelPortaliQ9X1E4.
SMRiQ9X1E4. Positions 2-495.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 822Substrate binding By similarity
Regioni242 – 2432Substrate binding By similarity

Sequence similaritiesi

Belongs to the FGGY kinase family.

Phylogenomic databases

eggNOGiCOG0554.
KOiK00864.
OMAiHFFGVEV.
OrthoDBiEOG6RZB46.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin.
InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X1E4-1 [UniParc]FASTAAdd to Basket

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MKYVLSLDQG TTSSRAIVFD EKGNVVSKVN KEFRQIYPRP GWVEHDPVEI    50
WESQIEVAKK AIEEAGIKPE DIAAIGITNQ RETTIVWDKN TGKPVYNAIV 100
WQCRRTAPIC DELKEKGYSE FIRERTGLVI DAYFSGTKIK WILDNVEGVR 150
EKAEKGEVLF GTVDTWLIWN LTGGRVHVTD YSNASRTMIF NIHKLDWDDE 200
ILELLNIPRA MLPQVMPSSH VYGYTAKDIF GVEIPIAGDA GDQQAALFGQ 250
ACFQPGMLKN TYGTGCFLLM NTGEKAFESK SGLLTTIAWG INGKVYYALE 300
GSIFITGAAV QWLRDGLKII SNAAETEELA TKVPDNGGVF FVPAFVGLGA 350
PYWDMYARGL IIGITRGTTR EHIVRAVLES IAYQTRDVVE VMEKDSDIKV 400
ETLRVDGGAV VNNFLMQFQA DILGVPVERP VVNETTALGA AYLAGLAVGY 450
WKDQEEIASL WQLDRRFEPS MNSEERERLY SKWKEAVSRS LGWEKR 496
Length:496
Mass (Da):55,576
Last modified:May 30, 2000 - v2
Checksum:i7FA72A4CBD29E701
GO

Sequence cautioni

The sequence AAD36500.1 differs from that shown. Reason: Erroneous termination at position 483. Translated as Trp.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36500.1. Sequence problems.
PIRiC72254.
RefSeqiNP_229230.1. NC_000853.1.
YP_007977785.1. NC_021214.1.

Genome annotation databases

EnsemblBacteriaiAAD36500; AAD36500; TM_1430.
GeneIDi898045.
KEGGitma:TM1430.
tmm:Tmari_1436.
PATRICi23937808. VBITheMar51294_1442.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36500.1 . Sequence problems.
PIRi C72254.
RefSeqi NP_229230.1. NC_000853.1.
YP_007977785.1. NC_021214.1.

3D structure databases

ProteinModelPortali Q9X1E4.
SMRi Q9X1E4. Positions 2-495.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243274.TM1430.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD36500 ; AAD36500 ; TM_1430 .
GeneIDi 898045.
KEGGi tma:TM1430.
tmm:Tmari_1436.
PATRICi 23937808. VBITheMar51294_1442.

Phylogenomic databases

eggNOGi COG0554.
KOi K00864.
OMAi HFFGVEV.
OrthoDBi EOG6RZB46.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00672 .
BioCyci TMAR243274:GC6P-1468-MONOMER.

Family and domain databases

HAMAPi MF_00186. Glycerol_kin.
InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiGLPK2_THEMA
AccessioniPrimary (citable) accession number: Q9X1E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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