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Protein

Phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (cdsA), Phosphatidate cytidylyltransferase (Tmari_1404)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
Ordered Locus Names:TM_1397
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000907581 – 270Phosphatidate cytidylyltransferaseAdd BLAST270

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1397.

Structurei

Secondary structure

1270
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 9Combined sources5
Helixi10 – 20Combined sources11
Helixi25 – 45Combined sources21
Helixi51 – 69Combined sources19
Turni70 – 72Combined sources3
Beta strandi73 – 75Combined sources3
Helixi76 – 93Combined sources18
Helixi97 – 113Combined sources17
Helixi115 – 118Combined sources4
Helixi121 – 154Combined sources34
Beta strandi162 – 164Combined sources3
Helixi169 – 191Combined sources23
Beta strandi193 – 195Combined sources3
Beta strandi201 – 203Combined sources3
Helixi204 – 229Combined sources26
Beta strandi232 – 234Combined sources3
Beta strandi239 – 242Combined sources4
Helixi244 – 265Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q2EX-ray3.40A/B1-270[»]
4Q2GX-ray3.40A/B1-270[»]
SMRiQ9X1B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105KNE. Bacteria.
COG0575. LUCA.
InParanoidiQ9X1B7.
KOiK00981.
OMAiFDSFAYF.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X1B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDLKTRVIT ASVVAPFVVL CFVSYESLIG LVSAILILAG YELITLEMKE
60 70 80 90 100
RDARFFYVIL LALYPVLYGL VFEEPTQPLS ILFITGVVFS LITDKDPSQV
110 120 130 140 150
FKTVAAFSIA LIYVTFFLSF FLPIYRDFGA ANALLVLTST WVFDSFAYFT
160 170 180 190 200
GLKFGRTRIS PRYSPRKSLE GVIGGFLGVV IYTFLYRLVV NDLLSVNVIS
210 220 230 240 250
FRTFLPFAAT VAIMDTFGDI FESALKRHYG VKDSGKTLPG HGGMLDRIDG
260 270
LLFVAPVSYI VFKILEGVVR
Length:270
Mass (Da):30,099
Last modified:November 1, 1999 - v1
Checksum:iBDAAF664120D7D3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36468.1.
PIRiF72259.
RefSeqiNP_229198.1. NC_000853.1.
WP_004081613.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36468; AAD36468; TM_1397.
GeneIDi898079.
KEGGitma:TM1397.
PATRICi23937740. VBITheMar51294_1409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36468.1.
PIRiF72259.
RefSeqiNP_229198.1. NC_000853.1.
WP_004081613.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q2EX-ray3.40A/B1-270[»]
4Q2GX-ray3.40A/B1-270[»]
SMRiQ9X1B7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1397.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36468; AAD36468; TM_1397.
GeneIDi898079.
KEGGitma:TM1397.
PATRICi23937740. VBITheMar51294_1409.

Phylogenomic databases

eggNOGiENOG4105KNE. Bacteria.
COG0575. LUCA.
InParanoidiQ9X1B7.
KOiK00981.
OMAiFDSFAYF.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDSA_THEMA
AccessioniPrimary (citable) accession number: Q9X1B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.