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Q9X1B7

- CDSA_THEMA

UniProt

Q9X1B7 - CDSA_THEMA

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Protein

Phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
Ordered Locus Names:TM_1397
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST
Transmembranei55 – 7521HelicalSequence AnalysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence AnalysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence AnalysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence AnalysisAdd
BLAST
Transmembranei193 – 21321HelicalSequence AnalysisAdd
BLAST
Transmembranei248 – 26821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Phosphatidate cytidylyltransferasePRO_0000090758Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1397.

Structurei

Secondary structure

1
270
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 2011Combined sources
Helixi25 – 4521Combined sources
Helixi51 – 6919Combined sources
Turni70 – 723Combined sources
Beta strandi73 – 753Combined sources
Helixi76 – 9318Combined sources
Helixi97 – 11317Combined sources
Helixi115 – 1184Combined sources
Helixi121 – 15434Combined sources
Beta strandi162 – 1643Combined sources
Helixi169 – 19123Combined sources
Beta strandi193 – 1953Combined sources
Beta strandi201 – 2033Combined sources
Helixi204 – 22926Combined sources
Beta strandi232 – 2343Combined sources
Beta strandi239 – 2424Combined sources
Helixi244 – 26522Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4Q2EX-ray3.40A/B1-270[»]
4Q2GX-ray3.40A/B1-270[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
InParanoidiQ9X1B7.
KOiK00981.
OMAiLEMKERD.
OrthoDBiEOG6TBHJT.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X1B7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDDLKTRVIT ASVVAPFVVL CFVSYESLIG LVSAILILAG YELITLEMKE
60 70 80 90 100
RDARFFYVIL LALYPVLYGL VFEEPTQPLS ILFITGVVFS LITDKDPSQV
110 120 130 140 150
FKTVAAFSIA LIYVTFFLSF FLPIYRDFGA ANALLVLTST WVFDSFAYFT
160 170 180 190 200
GLKFGRTRIS PRYSPRKSLE GVIGGFLGVV IYTFLYRLVV NDLLSVNVIS
210 220 230 240 250
FRTFLPFAAT VAIMDTFGDI FESALKRHYG VKDSGKTLPG HGGMLDRIDG
260 270
LLFVAPVSYI VFKILEGVVR
Length:270
Mass (Da):30,099
Last modified:November 1, 1999 - v1
Checksum:iBDAAF664120D7D3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36468.1.
PIRiF72259.
RefSeqiNP_229198.1. NC_000853.1.
WP_004081613.1. NC_023151.1.
YP_007977753.1. NC_021214.1.
YP_008991512.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD36468; AAD36468; TM_1397.
GeneIDi18093313.
898079.
KEGGitma:TM1397.
PATRICi23937740. VBITheMar51294_1409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36468.1 .
PIRi F72259.
RefSeqi NP_229198.1. NC_000853.1.
WP_004081613.1. NC_023151.1.
YP_007977753.1. NC_021214.1.
YP_008991512.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4Q2E X-ray 3.40 A/B 1-270 [» ]
4Q2G X-ray 3.40 A/B 1-270 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM1397.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD36468 ; AAD36468 ; TM_1397 .
GeneIDi 18093313.
898079.
KEGGi tma:TM1397.
PATRICi 23937740. VBITheMar51294_1409.

Phylogenomic databases

eggNOGi COG0575.
InParanoidi Q9X1B7.
KOi K00981.
OMAi LEMKERD.
OrthoDBi EOG6TBHJT.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00614 .

Family and domain databases

InterProi IPR000374. PC_trans.
[Graphical view ]
Pfami PF01148. CTP_transf_1. 1 hit.
[Graphical view ]
PROSITEi PS01315. CDS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiCDSA_THEMA
AccessioniPrimary (citable) accession number: Q9X1B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3