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Q9X1B3 (ISPD_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
EC=2.7.7.60
Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase
MEP cytidylyltransferase
Short name=MCT
Gene names
Name:ispD
Ordered Locus Names:TM_1393
OrganismThermotoga maritima
Taxonomic identifier2336 [NCBI]
Taxonomic lineageBacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108

Catalytic activity

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108

Sequence similarities

Belongs to the IspD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2222222-C-methyl-D-erythritol 4-phosphate cytidylyltransferase HAMAP MF_00108
PRO_0000075638

Sites

Site141Transition state stabilizer By similarity
Site211Transition state stabilizer By similarity
Site1491Positions MEP for the nucleophilic attack By similarity
Site2011Positions MEP for the nucleophilic attack By similarity

Secondary structure

1 ......................................... 222
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9X1B3 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 51D5E945D078ACEC

FASTA22225,370
        10         20         30         40         50         60 
MNVAILLAAG KGERMSENVP KQFLEIEGRM LFEYPLSTFL KSEAIDGVVI VTRREWFEVV 

        70         80         90        100        110        120 
EKRVFHEKVL GIVEGGDTRS QSVRSALEFL EKFSPSYVLV HDSARPFLRK KHVSEVLRRA 

       130        140        150        160        170        180 
RETGAATLAL KNSDALVRVE NDRIEYIPRK GVYRILTPQA FSYEILKKAH ENGGEWADDT 

       190        200        210        220 
EPVQKLGVKI ALVEGDPLCF KVTFKEDLEL ARIIAREWER IP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000512 Genomic DNA. Translation: AAD36464.1.
PIRB72259.
RefSeqNP_229194.1. NC_000853.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1VPAX-ray2.67A/B1-222[»]
ProteinModelPortalQ9X1B3.
SMRQ9X1B3. Positions 1-219.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID898083.
GenomeReviewsGene locus TM_1393 in contig AE000512_GR.
KEGGtma:TM1393.
NMPDRfig|243274.1.peg.1378.
PATRIC23937732. VBITheMar51294_1405.
TIGRTM_1393.

Phylogenomic databases

HOGENOMHBG672839.
OMAPSNIKVT.
PhylomeDBQ9X1B3.
ProtClustDBCLSK875736.

Enzyme and pathway databases

BioCycTMAR243274:TM_1393-MONOMER.

Family and domain databases

HAMAPMF_00108. IspD.
[Tree]
InterProIPR001228. ISPD_synthase.
IPR018294. ISPD_synthase_CS.
[Graphical view]
KOK00991.
PfamPF01128. IspD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00453. IspD. 1 hit.
PROSITEPS01295. ISPD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameISPD_THEMA
AccessionPrimary (citable) accession number: Q9X1B3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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