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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.By similarity

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX), Type III pantothenate kinase (coaX)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD), Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE), Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 148ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinase (EC:2.7.1.24)
Alternative name(s):
Dephosphocoenzyme A kinase
Gene namesi
Name:coaE
Ordered Locus Names:TM_1387
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Dephospho-CoA kinasePRO_0000173021Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1387.

Structurei

Secondary structure

180
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 66Combined sources
Helixi13 – 2412Combined sources
Beta strandi27 – 304Combined sources
Helixi31 – 4111Combined sources
Helixi43 – 508Combined sources
Helixi52 – 543Combined sources
Beta strandi55 – 606Combined sources
Helixi62 – 698Combined sources
Helixi73 – 9624Combined sources
Beta strandi100 – 1056Combined sources
Turni107 – 1137Combined sources
Helixi114 – 1174Combined sources
Beta strandi119 – 1257Combined sources
Helixi128 – 1347Combined sources
Helixi138 – 1425Combined sources
Beta strandi152 – 1565Combined sources
Helixi161 – 17515Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GRJX-ray2.60A/B/C/D/E/F/G/H1-180[»]
ProteinModelPortaliQ9X1A7.
SMRiQ9X1A7. Positions 1-176.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X1A7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 180179DPCKAdd
BLAST

Sequence similaritiesi

Belongs to the CoaE family.Curated

Phylogenomic databases

eggNOGiENOG41083IT. Bacteria.
COG0237. LUCA.
InParanoidiQ9X1A7.
KOiK00859.
OMAiDVDKEYH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase. 1 hit.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X1A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIGVTGKIG TGKSTVCEIL KNKYGAHVVN VDRIGHEVLE EVKEKLVELF
60 70 80 90 100
GGSVLEDGKV NRKKLAGIVF ESRENLKKLE LLVHPLMKKR VQEIINKTSG
110 120 130 140 150
LIVIEAALLK RMGLDQLCDH VITVVASRET ILKRNREADR RLKFQEDIVP
160 170 180
QGIVVANNST LEDLEKKVEE VMKLVWEKRE
Length:180
Mass (Da):20,331
Last modified:November 1, 1999 - v1
Checksum:i59321BA1139E5488
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36457.1.
PIRiD72262.
RefSeqiNP_229188.1. NC_000853.1.
WP_004081589.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36457; AAD36457; TM_1387.
GeneIDi898091.
KEGGitma:TM1387.
tmi:THEMA_07390.
tmw:THMA_1414.
PATRICi23937716. VBITheMar51294_1399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36457.1.
PIRiD72262.
RefSeqiNP_229188.1. NC_000853.1.
WP_004081589.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GRJX-ray2.60A/B/C/D/E/F/G/H1-180[»]
ProteinModelPortaliQ9X1A7.
SMRiQ9X1A7. Positions 1-176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1387.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36457; AAD36457; TM_1387.
GeneIDi898091.
KEGGitma:TM1387.
tmi:THEMA_07390.
tmw:THMA_1414.
PATRICi23937716. VBITheMar51294_1399.

Phylogenomic databases

eggNOGiENOG41083IT. Bacteria.
COG0237. LUCA.
InParanoidiQ9X1A7.
KOiK00859.
OMAiDVDKEYH.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.

Miscellaneous databases

EvolutionaryTraceiQ9X1A7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase. 1 hit.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOAE_THEMA
AccessioniPrimary (citable) accession number: Q9X1A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.