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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (pfp), ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei281Proton donorBy similarity1
Active sitei310By similarity1
Active sitei422By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-381.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:TM_1385
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001807571 – 448Glucose-6-phosphate isomeraseAdd BLAST448

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1385.

Structurei

Secondary structure

1448
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 6Combined sources3
Helixi8 – 10Combined sources3
Turni12 – 14Combined sources3
Helixi21 – 40Combined sources20
Helixi44 – 47Combined sources4
Helixi50 – 57Combined sources8
Helixi60 – 63Combined sources4
Beta strandi67 – 72Combined sources6
Helixi75 – 77Combined sources3
Helixi79 – 88Combined sources10
Helixi93 – 95Combined sources3
Turni98 – 103Combined sources6
Beta strandi106 – 110Combined sources5
Helixi115 – 122Combined sources8
Helixi127 – 129Combined sources3
Beta strandi130 – 135Combined sources6
Beta strandi137 – 139Combined sources3
Helixi142 – 157Combined sources16
Helixi162 – 164Combined sources3
Beta strandi166 – 170Combined sources5
Beta strandi172 – 175Combined sources4
Helixi176 – 184Combined sources9
Beta strandi187 – 190Combined sources4
Helixi197 – 199Combined sources3
Helixi204 – 212Combined sources9
Helixi217 – 230Combined sources14
Helixi236 – 238Combined sources3
Helixi240 – 253Combined sources14
Beta strandi258 – 265Combined sources8
Helixi266 – 268Combined sources3
Helixi269 – 283Combined sources15
Beta strandi299 – 304Combined sources6
Helixi307 – 309Combined sources3
Turni310 – 312Combined sources3
Helixi313 – 318Combined sources6
Beta strandi323 – 330Combined sources8
Helixi345 – 347Combined sources3
Turni348 – 352Combined sources5
Helixi355 – 372Combined sources18
Beta strandi377 – 385Combined sources9
Helixi387 – 407Combined sources21
Helixi416 – 418Combined sources3
Helixi419 – 428Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q8NX-ray1.82A/B/C1-448[»]
ProteinModelPortaliQ9X1A5.
SMRiQ9X1A5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X1A5.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiENOG4105C89. Bacteria.
COG0166. LUCA.
InParanoidiQ9X1A5.
KOiK01810.
OMAiKMTEWGI.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X1A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKFDFSNL FEPNISGGLT DEDVKSVEEK VTSAVRNFVE NTPDFAKLDR
60 70 80 90 100
SWIDSVKSLE DWIINFDTVV VLGIGGSGLG NLALHYSLRP LNWNEMTREE
110 120 130 140 150
RNGYARVFVV DNVDPDLMSS VLDRIDPKTT LFNVISKSGS TAEVMATYSI
160 170 180 190 200
ARGILEAYGL DPREHMLITT DPEKGFLRKL VKEEGFRSLE VPPGVGGRFS
210 220 230 240 250
VLTPVGLLSA MAEGIDIDEL HEGAKDAFEK SMKENILENP AAMIALTHYL
260 270 280 290 300
YLNKGKSISV MMAYSNRMIY LVDWYRQLWA ESLGKRYNLK GEEVFTGQTP
310 320 330 340 350
VKALGATDQH SQIQLYNEGP NDKVITFLRV ENFDREIVIP ETGRAELSYL
360 370 380 390 400
ARKKLSELLL AEQTGTEEAL RENNRPNMRV TFDGLTPYNV GQFFAYYEAA
410 420 430 440
TAFMGYLLEI NPFDQPGVEL GKKITFALMG REGYTYEIKE RSKKVIIE
Length:448
Mass (Da):50,493
Last modified:November 1, 1999 - v1
Checksum:i7FDE91F297851F71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36455.1.
PIRiB72262.
RefSeqiNP_229186.1. NC_000853.1.
WP_004081585.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36455; AAD36455; TM_1385.
GeneIDi898093.
KEGGitma:TM1385.
PATRICi23937712. VBITheMar51294_1397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36455.1.
PIRiB72262.
RefSeqiNP_229186.1. NC_000853.1.
WP_004081585.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q8NX-ray1.82A/B/C1-448[»]
ProteinModelPortaliQ9X1A5.
SMRiQ9X1A5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1385.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36455; AAD36455; TM_1385.
GeneIDi898093.
KEGGitma:TM1385.
PATRICi23937712. VBITheMar51294_1397.

Phylogenomic databases

eggNOGiENOG4105C89. Bacteria.
COG0166. LUCA.
InParanoidiQ9X1A5.
KOiK01810.
OMAiKMTEWGI.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciMetaCyc:MONOMER-381.

Miscellaneous databases

EvolutionaryTraceiQ9X1A5.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PI_THEMA
AccessioniPrimary (citable) accession number: Q9X1A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.