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Q9X1A5

- G6PI_THEMA

UniProt

Q9X1A5 - G6PI_THEMA

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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei281 – 2811Proton donorBy similarity
Active sitei310 – 3101By similarity
Active sitei422 – 4221By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-381.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:TM_1385
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Glucose-6-phosphate isomerasePRO_0000180757Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1385.

Structurei

Secondary structure

1
448
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 63Combined sources
Helixi8 – 103Combined sources
Turni12 – 143Combined sources
Helixi21 – 4020Combined sources
Helixi44 – 474Combined sources
Helixi50 – 578Combined sources
Helixi60 – 634Combined sources
Beta strandi67 – 726Combined sources
Helixi75 – 773Combined sources
Helixi79 – 8810Combined sources
Helixi93 – 953Combined sources
Turni98 – 1036Combined sources
Beta strandi106 – 1105Combined sources
Helixi115 – 1228Combined sources
Helixi127 – 1293Combined sources
Beta strandi130 – 1356Combined sources
Beta strandi137 – 1393Combined sources
Helixi142 – 15716Combined sources
Helixi162 – 1643Combined sources
Beta strandi166 – 1705Combined sources
Beta strandi172 – 1754Combined sources
Helixi176 – 1849Combined sources
Beta strandi187 – 1904Combined sources
Helixi197 – 1993Combined sources
Helixi204 – 2129Combined sources
Helixi217 – 23014Combined sources
Helixi236 – 2383Combined sources
Helixi240 – 25314Combined sources
Beta strandi258 – 2658Combined sources
Helixi266 – 2683Combined sources
Helixi269 – 28315Combined sources
Beta strandi299 – 3046Combined sources
Helixi307 – 3093Combined sources
Turni310 – 3123Combined sources
Helixi313 – 3186Combined sources
Beta strandi323 – 3308Combined sources
Helixi345 – 3473Combined sources
Turni348 – 3525Combined sources
Helixi355 – 37218Combined sources
Beta strandi377 – 3859Combined sources
Helixi387 – 40721Combined sources
Helixi416 – 4183Combined sources
Helixi419 – 42810Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Q8NX-ray1.82A/B/C1-448[»]
ProteinModelPortaliQ9X1A5.
SMRiQ9X1A5. Positions 1-448.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X1A5.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
InParanoidiQ9X1A5.
KOiK01810.
OMAiMIALTHY.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X1A5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLKFDFSNL FEPNISGGLT DEDVKSVEEK VTSAVRNFVE NTPDFAKLDR
60 70 80 90 100
SWIDSVKSLE DWIINFDTVV VLGIGGSGLG NLALHYSLRP LNWNEMTREE
110 120 130 140 150
RNGYARVFVV DNVDPDLMSS VLDRIDPKTT LFNVISKSGS TAEVMATYSI
160 170 180 190 200
ARGILEAYGL DPREHMLITT DPEKGFLRKL VKEEGFRSLE VPPGVGGRFS
210 220 230 240 250
VLTPVGLLSA MAEGIDIDEL HEGAKDAFEK SMKENILENP AAMIALTHYL
260 270 280 290 300
YLNKGKSISV MMAYSNRMIY LVDWYRQLWA ESLGKRYNLK GEEVFTGQTP
310 320 330 340 350
VKALGATDQH SQIQLYNEGP NDKVITFLRV ENFDREIVIP ETGRAELSYL
360 370 380 390 400
ARKKLSELLL AEQTGTEEAL RENNRPNMRV TFDGLTPYNV GQFFAYYEAA
410 420 430 440
TAFMGYLLEI NPFDQPGVEL GKKITFALMG REGYTYEIKE RSKKVIIE
Length:448
Mass (Da):50,493
Last modified:November 1, 1999 - v1
Checksum:i7FDE91F297851F71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36455.1.
PIRiB72262.
RefSeqiNP_229186.1. NC_000853.1.
YP_007977741.1. NC_021214.1.
YP_008991524.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD36455; AAD36455; TM_1385.
GeneIDi18093327.
898093.
KEGGitma:TM1385.
PATRICi23937712. VBITheMar51294_1397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36455.1 .
PIRi B72262.
RefSeqi NP_229186.1. NC_000853.1.
YP_007977741.1. NC_021214.1.
YP_008991524.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2Q8N X-ray 1.82 A/B/C 1-448 [» ]
ProteinModelPortali Q9X1A5.
SMRi Q9X1A5. Positions 1-448.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM1385.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD36455 ; AAD36455 ; TM_1385 .
GeneIDi 18093327.
898093.
KEGGi tma:TM1385.
PATRICi 23937712. VBITheMar51294_1397.

Phylogenomic databases

eggNOGi COG0166.
InParanoidi Q9X1A5.
KOi K01810.
OMAi MIALTHY.
OrthoDBi EOG64R61J.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
BioCyci MetaCyc:MONOMER-381.

Miscellaneous databases

EvolutionaryTracei Q9X1A5.

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiG6PI_THEMA
AccessioniPrimary (citable) accession number: Q9X1A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3