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Q9X1A5

- G6PI_THEMA

UniProt

Q9X1A5 - G6PI_THEMA

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Protein

Glucose-6-phosphate isomerase

Gene
pgi, TM_1385
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei281 – 2811Proton donor By similarity
Active sitei310 – 3101 By similarity
Active sitei422 – 4221 By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-381.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:TM_1385
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Glucose-6-phosphate isomeraseUniRule annotationPRO_0000180757Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1385.

Structurei

Secondary structure

1
448
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 63
Helixi8 – 103
Turni12 – 143
Helixi21 – 4020
Helixi44 – 474
Helixi50 – 578
Helixi60 – 634
Beta strandi67 – 726
Helixi75 – 773
Helixi79 – 8810
Helixi93 – 953
Turni98 – 1036
Beta strandi106 – 1105
Helixi115 – 1228
Helixi127 – 1293
Beta strandi130 – 1356
Beta strandi137 – 1393
Helixi142 – 15716
Helixi162 – 1643
Beta strandi166 – 1705
Beta strandi172 – 1754
Helixi176 – 1849
Beta strandi187 – 1904
Helixi197 – 1993
Helixi204 – 2129
Helixi217 – 23014
Helixi236 – 2383
Helixi240 – 25314
Beta strandi258 – 2658
Helixi266 – 2683
Helixi269 – 28315
Beta strandi299 – 3046
Helixi307 – 3093
Turni310 – 3123
Helixi313 – 3186
Beta strandi323 – 3308
Helixi345 – 3473
Turni348 – 3525
Helixi355 – 37218
Beta strandi377 – 3859
Helixi387 – 40721
Helixi416 – 4183
Helixi419 – 42810

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Q8NX-ray1.82A/B/C1-448[»]
ProteinModelPortaliQ9X1A5.
SMRiQ9X1A5. Positions 1-448.

Miscellaneous databases

EvolutionaryTraceiQ9X1A5.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.

Phylogenomic databases

eggNOGiCOG0166.
KOiK01810.
OMAiMIALTHY.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X1A5-1 [UniParc]FASTAAdd to Basket

« Hide

MSLKFDFSNL FEPNISGGLT DEDVKSVEEK VTSAVRNFVE NTPDFAKLDR    50
SWIDSVKSLE DWIINFDTVV VLGIGGSGLG NLALHYSLRP LNWNEMTREE 100
RNGYARVFVV DNVDPDLMSS VLDRIDPKTT LFNVISKSGS TAEVMATYSI 150
ARGILEAYGL DPREHMLITT DPEKGFLRKL VKEEGFRSLE VPPGVGGRFS 200
VLTPVGLLSA MAEGIDIDEL HEGAKDAFEK SMKENILENP AAMIALTHYL 250
YLNKGKSISV MMAYSNRMIY LVDWYRQLWA ESLGKRYNLK GEEVFTGQTP 300
VKALGATDQH SQIQLYNEGP NDKVITFLRV ENFDREIVIP ETGRAELSYL 350
ARKKLSELLL AEQTGTEEAL RENNRPNMRV TFDGLTPYNV GQFFAYYEAA 400
TAFMGYLLEI NPFDQPGVEL GKKITFALMG REGYTYEIKE RSKKVIIE 448
Length:448
Mass (Da):50,493
Last modified:November 1, 1999 - v1
Checksum:i7FDE91F297851F71
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36455.1.
PIRiB72262.
RefSeqiNP_229186.1. NC_000853.1.
YP_007977741.1. NC_021214.1.
YP_008991524.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD36455; AAD36455; TM_1385.
GeneIDi898093.
KEGGitma:TM1385.
tmi:THEMA_07400.
tmm:Tmari_1392.
PATRICi23937712. VBITheMar51294_1397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36455.1 .
PIRi B72262.
RefSeqi NP_229186.1. NC_000853.1.
YP_007977741.1. NC_021214.1.
YP_008991524.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2Q8N X-ray 1.82 A/B/C 1-448 [» ]
ProteinModelPortali Q9X1A5.
SMRi Q9X1A5. Positions 1-448.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM1385.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD36455 ; AAD36455 ; TM_1385 .
GeneIDi 898093.
KEGGi tma:TM1385.
tmi:THEMA_07400.
tmm:Tmari_1392.
PATRICi 23937712. VBITheMar51294_1397.

Phylogenomic databases

eggNOGi COG0166.
KOi K01810.
OMAi MIALTHY.
OrthoDBi EOG64R61J.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
BioCyci MetaCyc:MONOMER-381.

Miscellaneous databases

EvolutionaryTracei Q9X1A5.

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiG6PI_THEMA
AccessioniPrimary (citable) accession number: Q9X1A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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