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Q9X1A5

- G6PI_THEMA

UniProt

Q9X1A5 - G6PI_THEMA

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei281 – 2811Proton donorBy similarity
    Active sitei310 – 3101By similarity
    Active sitei422 – 4221By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-381.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:pgi
    Ordered Locus Names:TM_1385
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448Glucose-6-phosphate isomerasePRO_0000180757Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243274.TM1385.

    Structurei

    Secondary structure

    1
    448
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 63
    Helixi8 – 103
    Turni12 – 143
    Helixi21 – 4020
    Helixi44 – 474
    Helixi50 – 578
    Helixi60 – 634
    Beta strandi67 – 726
    Helixi75 – 773
    Helixi79 – 8810
    Helixi93 – 953
    Turni98 – 1036
    Beta strandi106 – 1105
    Helixi115 – 1228
    Helixi127 – 1293
    Beta strandi130 – 1356
    Beta strandi137 – 1393
    Helixi142 – 15716
    Helixi162 – 1643
    Beta strandi166 – 1705
    Beta strandi172 – 1754
    Helixi176 – 1849
    Beta strandi187 – 1904
    Helixi197 – 1993
    Helixi204 – 2129
    Helixi217 – 23014
    Helixi236 – 2383
    Helixi240 – 25314
    Beta strandi258 – 2658
    Helixi266 – 2683
    Helixi269 – 28315
    Beta strandi299 – 3046
    Helixi307 – 3093
    Turni310 – 3123
    Helixi313 – 3186
    Beta strandi323 – 3308
    Helixi345 – 3473
    Turni348 – 3525
    Helixi355 – 37218
    Beta strandi377 – 3859
    Helixi387 – 40721
    Helixi416 – 4183
    Helixi419 – 42810

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2Q8NX-ray1.82A/B/C1-448[»]
    ProteinModelPortaliQ9X1A5.
    SMRiQ9X1A5. Positions 1-448.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9X1A5.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Phylogenomic databases

    eggNOGiCOG0166.
    KOiK01810.
    OMAiMIALTHY.
    OrthoDBiEOG64R61J.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9X1A5-1 [UniParc]FASTAAdd to Basket

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    MSLKFDFSNL FEPNISGGLT DEDVKSVEEK VTSAVRNFVE NTPDFAKLDR    50
    SWIDSVKSLE DWIINFDTVV VLGIGGSGLG NLALHYSLRP LNWNEMTREE 100
    RNGYARVFVV DNVDPDLMSS VLDRIDPKTT LFNVISKSGS TAEVMATYSI 150
    ARGILEAYGL DPREHMLITT DPEKGFLRKL VKEEGFRSLE VPPGVGGRFS 200
    VLTPVGLLSA MAEGIDIDEL HEGAKDAFEK SMKENILENP AAMIALTHYL 250
    YLNKGKSISV MMAYSNRMIY LVDWYRQLWA ESLGKRYNLK GEEVFTGQTP 300
    VKALGATDQH SQIQLYNEGP NDKVITFLRV ENFDREIVIP ETGRAELSYL 350
    ARKKLSELLL AEQTGTEEAL RENNRPNMRV TFDGLTPYNV GQFFAYYEAA 400
    TAFMGYLLEI NPFDQPGVEL GKKITFALMG REGYTYEIKE RSKKVIIE 448
    Length:448
    Mass (Da):50,493
    Last modified:November 1, 1999 - v1
    Checksum:i7FDE91F297851F71
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36455.1.
    PIRiB72262.
    RefSeqiNP_229186.1. NC_000853.1.
    YP_007977741.1. NC_021214.1.
    YP_008991524.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD36455; AAD36455; TM_1385.
    GeneIDi898093.
    KEGGitma:TM1385.
    tmi:THEMA_07400.
    tmm:Tmari_1392.
    PATRICi23937712. VBITheMar51294_1397.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36455.1 .
    PIRi B72262.
    RefSeqi NP_229186.1. NC_000853.1.
    YP_007977741.1. NC_021214.1.
    YP_008991524.1. NC_023151.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2Q8N X-ray 1.82 A/B/C 1-448 [» ]
    ProteinModelPortali Q9X1A5.
    SMRi Q9X1A5. Positions 1-448.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243274.TM1385.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD36455 ; AAD36455 ; TM_1385 .
    GeneIDi 898093.
    KEGGi tma:TM1385.
    tmi:THEMA_07400.
    tmm:Tmari_1392.
    PATRICi 23937712. VBITheMar51294_1397.

    Phylogenomic databases

    eggNOGi COG0166.
    KOi K01810.
    OMAi MIALTHY.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    BioCyci MetaCyc:MONOMER-381.

    Miscellaneous databases

    EvolutionaryTracei Q9X1A5.

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

    Entry informationi

    Entry nameiG6PI_THEMA
    AccessioniPrimary (citable) accession number: Q9X1A5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3