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Protein

Peptide chain release factor 1

Gene

prfA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 1
Short name:
RF-1
Gene namesi
Name:prfA
Ordered Locus Names:TM_1363
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Peptide chain release factor 1PRO_0000177761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei211 – 2111N5-methylglutamineBy similarity

Post-translational modificationi

Methylated by PrmC. Methylation increases the termination efficiency of RF1 (By similarity).By similarity

Keywords - PTMi

Methylation

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1363.

Structurei

Secondary structure

1
342
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni2 – 65Combined sources
Helixi7 – 137Combined sources
Helixi19 – 4931Combined sources
Turni50 – 578Combined sources
Helixi62 – 8019Combined sources
Beta strandi86 – 949Combined sources
Helixi99 – 11921Combined sources
Beta strandi122 – 1309Combined sources
Beta strandi136 – 14510Combined sources
Helixi148 – 1525Combined sources
Helixi153 – 1553Combined sources
Beta strandi157 – 1637Combined sources
Beta strandi174 – 18411Combined sources
Helixi188 – 1903Combined sources
Helixi195 – 1973Combined sources
Beta strandi198 – 2036Combined sources
Beta strandi214 – 22411Combined sources
Turni225 – 2273Combined sources
Beta strandi230 – 2378Combined sources
Helixi239 – 26325Combined sources
Turni264 – 2663Combined sources
Beta strandi282 – 2876Combined sources
Turni288 – 2914Combined sources
Beta strandi292 – 2954Combined sources
Turni296 – 2994Combined sources
Beta strandi300 – 3034Combined sources
Helixi305 – 3095Combined sources
Helixi314 – 32512Combined sources
Turni326 – 3283Combined sources
Helixi329 – 3324Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RQ0X-ray2.65A/B/C1-342[»]
2FVOelectron microscopy12.80A1-333[»]
ProteinModelPortaliQ9X183.
SMRiQ9X183. Positions 1-333.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X183.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C8K. Bacteria.
COG0216. LUCA.
InParanoidiQ9X183.
KOiK02835.
OMAiESQGRLH.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00093. Rel_fac_1. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00019. prfA. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X183-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEKKKEIEK LLARPDLTPE QMKNYGMEYA KIEEIENITN RIKETQEFIE
60 70 80 90 100
LLREEGENEL EIEKYEKELD QLYQELLFLL SPEASDKAIV EIRPGTGGEE
110 120 130 140 150
AALFARDLFR MYTRYAERKG WNLEVAEIHE TDLGGIREVV FFVKGKNAYG
160 170 180 190 200
ILKYESGVHR VQRVPVTESG GRIHTSTATV AVLPEIEEKD IEIRPEDLKI
210 220 230 240 250
ETFRASGHGG QYVNKTESAV RITHLPTGIV VSCQNERSQY QNKQTALRIL
260 270 280 290 300
RARLYQLQKE QKEREISQKR KSQIGTGERS EKIRTYNFPQ NRVTDHRINY
310 320 330 340
TSYRLQEILD GDLDEIISKL IEHDIENNLE EVLGIGASVE EK
Length:342
Mass (Da):39,657
Last modified:November 1, 1999 - v1
Checksum:iBEA59866A68F12F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36433.1.
PIRiD72263.
RefSeqiNP_229164.1. NC_000853.1.
WP_004081559.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36433; AAD36433; TM_1363.
GeneIDi898117.
KEGGitma:TM1363.
tmi:THEMA_07525.
tmw:THMA_1388.
PATRICi23937664. VBITheMar51294_1375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36433.1.
PIRiD72263.
RefSeqiNP_229164.1. NC_000853.1.
WP_004081559.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RQ0X-ray2.65A/B/C1-342[»]
2FVOelectron microscopy12.80A1-333[»]
ProteinModelPortaliQ9X183.
SMRiQ9X183. Positions 1-333.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1363.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36433; AAD36433; TM_1363.
GeneIDi898117.
KEGGitma:TM1363.
tmi:THEMA_07525.
tmw:THMA_1388.
PATRICi23937664. VBITheMar51294_1375.

Phylogenomic databases

eggNOGiENOG4105C8K. Bacteria.
COG0216. LUCA.
InParanoidiQ9X183.
KOiK02835.
OMAiESQGRLH.

Miscellaneous databases

EvolutionaryTraceiQ9X183.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00093. Rel_fac_1. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00019. prfA. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRF1_THEMA
AccessioniPrimary (citable) accession number: Q9X183
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.