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Protein

Peptide chain release factor 1

Gene

prfA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 1
Short name:
RF-1
Gene namesi
Name:prfA
Ordered Locus Names:TM_1363
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001777611 – 342Peptide chain release factor 1Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei211N5-methylglutamineBy similarity1

Post-translational modificationi

Methylated by PrmC. Methylation increases the termination efficiency of RF1 (By similarity).By similarity

Keywords - PTMi

Methylation

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1363.

Structurei

Secondary structure

1342
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni2 – 6Combined sources5
Helixi7 – 13Combined sources7
Helixi19 – 49Combined sources31
Turni50 – 57Combined sources8
Helixi62 – 80Combined sources19
Beta strandi86 – 94Combined sources9
Helixi99 – 119Combined sources21
Beta strandi122 – 130Combined sources9
Beta strandi136 – 145Combined sources10
Helixi148 – 152Combined sources5
Helixi153 – 155Combined sources3
Beta strandi157 – 163Combined sources7
Beta strandi174 – 184Combined sources11
Helixi188 – 190Combined sources3
Helixi195 – 197Combined sources3
Beta strandi198 – 203Combined sources6
Beta strandi214 – 224Combined sources11
Turni225 – 227Combined sources3
Beta strandi230 – 237Combined sources8
Helixi239 – 263Combined sources25
Turni264 – 266Combined sources3
Beta strandi282 – 287Combined sources6
Turni288 – 291Combined sources4
Beta strandi292 – 295Combined sources4
Turni296 – 299Combined sources4
Beta strandi300 – 303Combined sources4
Helixi305 – 309Combined sources5
Helixi314 – 325Combined sources12
Turni326 – 328Combined sources3
Helixi329 – 332Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RQ0X-ray2.65A/B/C1-342[»]
2FVOelectron microscopy12.80A1-333[»]
ProteinModelPortaliQ9X183.
SMRiQ9X183.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X183.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C8K. Bacteria.
COG0216. LUCA.
InParanoidiQ9X183.
KOiK02835.
OMAiESQGRLH.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00093. Rel_fac_1. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00019. prfA. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X183-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEKKKEIEK LLARPDLTPE QMKNYGMEYA KIEEIENITN RIKETQEFIE
60 70 80 90 100
LLREEGENEL EIEKYEKELD QLYQELLFLL SPEASDKAIV EIRPGTGGEE
110 120 130 140 150
AALFARDLFR MYTRYAERKG WNLEVAEIHE TDLGGIREVV FFVKGKNAYG
160 170 180 190 200
ILKYESGVHR VQRVPVTESG GRIHTSTATV AVLPEIEEKD IEIRPEDLKI
210 220 230 240 250
ETFRASGHGG QYVNKTESAV RITHLPTGIV VSCQNERSQY QNKQTALRIL
260 270 280 290 300
RARLYQLQKE QKEREISQKR KSQIGTGERS EKIRTYNFPQ NRVTDHRINY
310 320 330 340
TSYRLQEILD GDLDEIISKL IEHDIENNLE EVLGIGASVE EK
Length:342
Mass (Da):39,657
Last modified:November 1, 1999 - v1
Checksum:iBEA59866A68F12F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36433.1.
PIRiD72263.
RefSeqiNP_229164.1. NC_000853.1.
WP_004081559.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36433; AAD36433; TM_1363.
GeneIDi898117.
KEGGitma:TM1363.
PATRICi23937664. VBITheMar51294_1375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36433.1.
PIRiD72263.
RefSeqiNP_229164.1. NC_000853.1.
WP_004081559.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RQ0X-ray2.65A/B/C1-342[»]
2FVOelectron microscopy12.80A1-333[»]
ProteinModelPortaliQ9X183.
SMRiQ9X183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1363.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36433; AAD36433; TM_1363.
GeneIDi898117.
KEGGitma:TM1363.
PATRICi23937664. VBITheMar51294_1375.

Phylogenomic databases

eggNOGiENOG4105C8K. Bacteria.
COG0216. LUCA.
InParanoidiQ9X183.
KOiK02835.
OMAiESQGRLH.

Miscellaneous databases

EvolutionaryTraceiQ9X183.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00093. Rel_fac_1. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00019. prfA. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRF1_THEMA
AccessioniPrimary (citable) accession number: Q9X183
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.