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Protein
Submitted name:

Sensor histidine kinase

Gene

TM_1359

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei661ADPCombined sources1
Binding sitei689ADPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi708 – 710ADPCombined sources3
Nucleotide bindingi714 – 718ADPCombined sources5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseSAAS annotationImported, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTMAR243274:G1H0Q-1509-MONOMER
BRENDAi2.7.13.3 6331

Names & Taxonomyi

Protein namesi
Submitted name:
Sensor histidine kinaseImported
Gene namesi
Ordered Locus Names:TM_1359Imported
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Imported
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Chemistry databases

DrugBankiDB02731 Ethylmercurithiosalicylic acid

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TM_1360Q9X1815EBI-15809993,EBI-15810022

Protein-protein interaction databases

DIPiDIP-48290N
IntActiQ9X180 1 interactor.
STRINGi243274.TM1359

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A0RX-ray3.80A408-755[»]
3A0SX-ray1.47A424-518[»]
3A0TX-ray1.91A605-755[»]
3A0VX-ray1.70A424-518[»]
3A0WX-ray1.69A/B605-755[»]
3A0XX-ray1.89A605-755[»]
3A0YX-ray1.57A/B605-755[»]
3A0ZX-ray1.75A/B605-755[»]
SMRiQ9X180
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini412 – 457PASInterPro annotationAdd BLAST46
Domaini544 – 752Histidine kinaseInterPro annotationAdd BLAST209

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili152 – 190Sequence analysisAdd BLAST39

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105ES5 Bacteria
COG0642 LUCA
COG2202 LUCA
COG2203 LUCA
KOiK02486
OMAiKANQRAM

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
cd00082 HisKA, 1 hit
cd00130 PAS, 1 hit
Gene3Di3.30.565.101 hit
InterProiView protein in InterPro
IPR003018 GAF
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR004358 Sig_transdc_His_kin-like_C
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PF00989 PAS, 1 hit
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00065 GAF, 1 hit
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF47384 SSF47384, 1 hit
SSF55785 SSF55785, 1 hit
SSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50109 HIS_KIN, 1 hit
PS50112 PAS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9X180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPERLKQIK GIRILESEDE IPQEGFTCRF GKHTVVANDE ESFEIVRLYK
60 70 80 90 100
RLTVYELLLS LVDSICVHPK EEALRFSLKK VREFLDAEEV YLIEGDASYS
110 120 130 140 150
SKGEKLSIDE IKKKHPGASV REWRNKLHLV VVREGAFDEE EEVLCTKLLE
160 170 180 190 200
FIGNVSEKLW RLKEEVQKLK KSYEEQLKVS EIQKEHIKKM RIIYYVSQAM
210 220 230 240 250
RSVYDPNNLY RVILLSLVSE RGFNFDRAVL LKKDEGTGSL MVVSAVGGDT
260 270 280 290 300
LQEHEELKRY LRKRTLRYTD LVQFLREEAL TFSFETKFNE KIRGKRFYYR
310 320 330 340 350
EHPIFERVVL RKSIVRTSRE TLEKIRYEIE DVISILENDE FIVFPLVGRW
360 370 380 390 400
DTLGVVVVDN KFSKKEVTDL DLDVLKLFSE SAGLALENAY NYENLRKKTL
410 420 430 440 450
DLQRQNELVE HLRNFSESIL ESLETAIITL SKDGRITEWN KKAEQLFGLK
460 470 480 490 500
KENVLGRRLK DLPDFEEIGS VAESVFENKE PVFLNFYKFG ERYFNIRFSP
510 520 530 540 550
FRNAKTQLLE GVIITIDDVT ELYKYEEERK RRERLSILGE MTARVAHEIR
560 570 580 590 600
NPITIIGGFI MRMKKHLDDP ETLKKYINII TNELSRLETI VKEILEYSKE
610 620 630 640 650
RQVLEFTEFN LNELIREVYV LFEEKIRKMN IDFCFETDNE DLRVEADRTR
660 670 680 690 700
IKQVLINLVQ NAIEATGENG KIKITSEDMY TKVRVSVWNS GPPIPEELKE
710 720 730 740 750
KIFSPFFTTK TQGTGLGLSI CRKIIEDEHG GKIWTENREN GVVFIFEIPK

TPEKR
Length:755
Mass (Da):88,729
Last modified:November 1, 1999 - v1
Checksum:i61D11F4FDC4D0E9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA Translation: AAD36429.1
PIRiH72262
RefSeqiNP_229160.1, NC_000853.1
WP_004081555.1, NZ_CP011107.1

Genome annotation databases

EnsemblBacteriaiAAD36429; AAD36429; TM_1359
AGL50290; AGL50290; Tmari_1366
GeneIDi898121
KEGGitma:TM1359
tmi:THEMA_07545
tmw:THMA_1384
PATRICifig|243274.17.peg.1366

Similar proteinsi

Entry informationi

Entry nameiQ9X180_THEMA
AccessioniPrimary (citable) accession number: Q9X180
Secondary accession number(s): G4FF95
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported