Q9X168 (Q9X168_THEMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Inosine-5'-monophosphate dehydrogenase RuleBase RU003928
EC=1.1.1.205 RuleBase RU003928

Gene names

Ordered Locus Names:

TM_1347

Organism

Thermotoga maritima

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	482 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH. RuleBase RU003928
Pathway	Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1. RuleBase RU003928
Sequence similarities	Belongs to the IMPDH/GMPR family. RuleBase RU003927

Ontologies

Keywords
Biological process	GMP biosynthesis RuleBase RU003928 Purine biosynthesis
Ligand	Metal-binding RuleBase RU003928 NAD RuleBase RU003928 Potassium RuleBase RU003928
Molecular function	Oxidoreductase SAAS SAAS001093 RuleBase RU003927
Technical term	3D-structure PDB 1VRD Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	GMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	IMP dehydrogenase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	301	1	Thioimidate intermediate By similarity PIRSR PIRSR000130-1

Sequences

	Sequence		Length	Mass (Da)
	Q9X168 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 4E08237F69D909FA	FASTA	482	52,014
	10 20 30 40 50 60 MKEALTFDDV LLVPQYSEVL PKDVKIDTRL TRQIRINIPL VSAAMDTVTE AALAKALARE 70 80 90 100 110 120 GGIGIIHKNL TPDEQARQVS IVKKTENGII YDPITVTPDM TVKEAIDLMA EYKIGGLPVV 130 140 150 160 170 180 DEEGRLVGLL TNRDVRFEKN LSKKIKDLMT PREKLIVAPP DISLEKAKEI LHQHRIEKLP 190 200 210 220 230 240 LVSKDNKLVG LITIKDIMSV IEHPNAARDE KGRLLVGAAV GTSPETMERV EKLVKAGVDV 250 260 270 280 290 300 IVIDTAHGHS RRVIETLEMI KADYPDLPVV AGNVATPEGT EALIKAGADA VKVGVGPGSI 310 320 330 340 350 360 CTTRVVAGVG VPQLTAVMEC SEVARKYDVP IIADGGIRYS GDIVKALAAG AESVMVGSIF 370 380 390 400 410 420 AGTEEAPGET ILYQGRKYKA YRGMGSLGAM RSGSADRYGQ EGENKFVPEG IEGMVPYKGT 430 440 450 460 470 480 VKDVVHQLVG GLRSGMGYIG ARTIKELQEK AVFVKITPAG VKESHPHDII ITKESPNYWV QA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
[2]	"Crystal structure of Inosine-5'-monophosphate dehydrogenase (TM1347) from THERMOTOGA MARITIMA at 2.18 A resolution." Joint Center for Structural Genomics (JCSG) Submitted (FEB-2005) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000512 Genomic DNA. Translation: AAD36418.1.

PIR

C72264.

RefSeq

NP_229148.1. NC_000853.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1VRD	X-ray	2.18	A/B	1-482	[»]

ProteinModelPortal

Q9X168.

SMR

Q9X168. Positions 1-457.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

898133.

GenomeReviews

Gene locus TM_1347 in contig AE000512_GR.

KEGG

tma:TM1347.

NMPDR

fig|243274.1.peg.1332.

PATRIC

23937632. VBITheMar51294_1359.

TIGR

TM_1347.

Phylogenomic databases

HOGENOM

HBG298985.

OMA

GIGIVHK.

PhylomeDB

Q9X168.

ProtClustDB

CLSK875702.

Enzyme and pathway databases

BioCyc

TMAR243274:TM_1347-MONOMER.

Family and domain databases

InterPro

IPR013785. Aldolase_TIM.
IPR000644. Cysta_beta_synth_core.
IPR005990. IMP_DH.
IPR018529. IMP_DH-rel.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]

Gene3D

G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.

KO

K00088.

Pfam

PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]

PIRSF

PIRSF000130. IMPDH. 1 hit.

SMART

SM00116. CBS. 2 hits.
[Graphical view]

TIGRFAMs

TIGR01302. IMP_dehydrog. 1 hit.

PROSITE

PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q9X168_THEMA

Accession

Primary (citable) accession number: Q9X168

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	December 14, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)