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Q9X166

- PNP_THEMA

UniProt

Q9X166 - PNP_THEMA

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi488 – 4881MagnesiumUniRule annotation
Metal bindingi494 – 4941MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:TM_1345
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 708708Polyribonucleotide nucleotidyltransferasePRO_0000329913Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1345.

Structurei

3D structure databases

ProteinModelPortaliQ9X166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 61561KHUniRule annotationAdd
BLAST
Domaini625 – 69268S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
InParanoidiQ9X166.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X166-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEWRRNILG RELVVQYGKV AKQSSGSALV RFGDTVVLAT ANISDKAVEG
60 70 80 90 100
IDFVPLTVEF QERFYAAGKI PGGFIKREGK PSESAILSAR LIDRPIRPLF
110 120 130 140 150
PKKLRNEVQV IVTVLSVDPN VPPDVVGIFA ASLALNVSKI PFEGIVAGIR
160 170 180 190 200
VGYRDGQFIA LPSEEDIEKG LMDITVAGTK DAVTMVEGEA KEVTEEDMVK
210 220 230 240 250
ALRFAHSVIK ELVDFQEEIL SEFNVEKIPV VEPTPPEGLV EAFKDLLNKE
260 270 280 290 300
ELERRILVKV KKEREVALKE YEEQLLNQIA EKLSVTDLEG IKPFVSELYE
310 320 330 340 350
DAVKKTMRRL IVEKGIRADG RKPTEIRPIS CEVGLFPRTH GSALFTRGET
360 370 380 390 400
QSLGIVTLGA PMDVQIIDTL LEEGVKRFML HYNFPPFCTG EVKPLRGPSR
410 420 430 440 450
REIGHGHLAE RALKNMLPPE EEFPYTIRVV SEILESNGSS SMATVCSGSL
460 470 480 490 500
ALMDAGVPIK KHVAGIAMGL ILEEDAEIIL TDIIGMEDHY GDMDFKVAGT
510 520 530 540 550
RDGITAFQMD CKVSGVSDEL LMKALMQARE ARMYILDRMY ETISAPRPHL
560 570 580 590 600
SKYAPIIKVT KVDPEKVADV IGPGGRVIKK IIKDFDVKVE IDDETGLVKV
610 620 630 640 650
VGSSEENVDK AIELIREIAK EIEVGEVLEG KVTRIEPYGL FIEVRPGKIG
660 670 680 690 700
LLHQSKVGED MRQFLKKVKV GDTIKVQVIN IDDLGRLQFK RVTEGENTQH

GKTHSKRN
Length:708
Mass (Da):78,621
Last modified:November 1, 1999 - v1
Checksum:iEC60D158C1725BC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36416.1.
PIRiA72264.
RefSeqiNP_229146.1. NC_000853.1.
YP_007977701.1. NC_021214.1.
YP_008991564.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD36416; AAD36416; TM_1345.
GeneIDi18093369.
898135.
KEGGitma:TM1345.
PATRICi23937628. VBITheMar51294_1357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36416.1 .
PIRi A72264.
RefSeqi NP_229146.1. NC_000853.1.
YP_007977701.1. NC_021214.1.
YP_008991564.1. NC_023151.1.

3D structure databases

ProteinModelPortali Q9X166.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM1345.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD36416 ; AAD36416 ; TM_1345 .
GeneIDi 18093369.
898135.
KEGGi tma:TM1345.
PATRICi 23937628. VBITheMar51294_1357.

Phylogenomic databases

eggNOGi COG1185.
InParanoidi Q9X166.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiPNP_THEMA
AccessioniPrimary (citable) accession number: Q9X166
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3