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Protein

Aspartate aminotransferase

Gene

aspC

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37Aspartate; via amide nitrogenBy similarity1
Binding sitei123AspartateBy similarity1
Binding sitei173AspartateBy similarity1
Binding sitei353AspartateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase (EC:2.6.1.1)
Short name:
AspAT
Alternative name(s):
Transaminase A
Gene namesi
Name:aspC
Ordered Locus Names:TM_1255
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238571 – 377Aspartate aminotransferaseAdd BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei234N6-(pyridoxal phosphate)lysine1

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi243274.TM1255.

Structurei

Secondary structure

1377
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 8Combined sources5
Helixi15 – 26Combined sources12
Helixi45 – 55Combined sources11
Helixi69 – 83Combined sources15
Helixi89 – 91Combined sources3
Beta strandi92 – 96Combined sources5
Helixi97 – 109Combined sources13
Beta strandi115 – 121Combined sources7
Helixi126 – 132Combined sources7
Beta strandi136 – 141Combined sources6
Helixi144 – 146Combined sources3
Helixi152 – 157Combined sources6
Beta strandi163 – 171Combined sources9
Turni173 – 175Combined sources3
Helixi181 – 194Combined sources14
Beta strandi197 – 201Combined sources5
Turni203 – 206Combined sources4
Helixi216 – 219Combined sources4
Beta strandi221 – 223Combined sources3
Beta strandi226 – 232Combined sources7
Turni233 – 237Combined sources5
Helixi239 – 241Combined sources3
Beta strandi244 – 247Combined sources4
Helixi250 – 263Combined sources14
Helixi269 – 278Combined sources10
Helixi284 – 303Combined sources20
Beta strandi312 – 320Combined sources9
Helixi325 – 336Combined sources12
Helixi343 – 346Combined sources4
Beta strandi351 – 355Combined sources5
Helixi360 – 374Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O4SX-ray1.90A/B1-377[»]
ProteinModelPortaliQ9X0Y2.
SMRiQ9X0Y2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X0Y2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHM. Bacteria.
COG0436. LUCA.
InParanoidiQ9X0Y2.
KOiK00812.
OMAiYIWVDIS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X0Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSRRISEIP ISKTMELDAK AKALIKKGED VINLTAGEPD FPTPEPVVEE
60 70 80 90 100
AVRFLQKGEV KYTDPRGIYE LREGIAKRIG ERYKKDISPD QVVVTNGAKQ
110 120 130 140 150
ALFNAFMALL DPGDEVIVFS PVWVSYIPQI ILAGGTVNVV ETFMSKNFQP
160 170 180 190 200
SLEEVEGLLV GKTKAVLINS PNNPTGVVYR REFLEGLVRL AKKRNFYIIS
210 220 230 240 250
DEVYDSLVYT DEFTSILDVS EGFDRIVYIN GFSKSHSMTG WRVGYLISSE
260 270 280 290 300
KVATAVSKIQ SHTTSCINTV AQYAALKALE VDNSYMVQTF KERKNFVVER
310 320 330 340 350
LKKMGVKFVE PEGAFYLFFK VRGDDVKFCE RLLEEKKVAL VPGSAFLKPG
360 370
FVRLSFATSI ERLTEALDRI EDFLNSR
Length:377
Mass (Da):42,421
Last modified:November 1, 1999 - v1
Checksum:i4EB507704C45E221
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36330.1.
PIRiB72275.
RefSeqiNP_229060.1. NC_000853.1.
WP_004080007.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36330; AAD36330; TM_1255.
GeneIDi898228.
KEGGitma:TM1255.
PATRICi23937450. VBITheMar51294_1271.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36330.1.
PIRiB72275.
RefSeqiNP_229060.1. NC_000853.1.
WP_004080007.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O4SX-ray1.90A/B1-377[»]
ProteinModelPortaliQ9X0Y2.
SMRiQ9X0Y2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1255.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36330; AAD36330; TM_1255.
GeneIDi898228.
KEGGitma:TM1255.
PATRICi23937450. VBITheMar51294_1271.

Phylogenomic databases

eggNOGiENOG4105CHM. Bacteria.
COG0436. LUCA.
InParanoidiQ9X0Y2.
KOiK00812.
OMAiYIWVDIS.

Miscellaneous databases

EvolutionaryTraceiQ9X0Y2.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAAT_THEMA
AccessioniPrimary (citable) accession number: Q9X0Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.