Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aspartate aminotransferase

Gene

aspC

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371Aspartate; via amide nitrogenBy similarity
Binding sitei123 – 1231AspartateBy similarity
Binding sitei173 – 1731AspartateBy similarity
Binding sitei353 – 3531AspartateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase (EC:2.6.1.1)
Short name:
AspAT
Alternative name(s):
Transaminase A
Gene namesi
Name:aspC
Ordered Locus Names:TM_1255
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Aspartate aminotransferasePRO_0000123857Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei234 – 2341N6-(pyridoxal phosphate)lysine

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi243274.TM1255.

Structurei

Secondary structure

1
377
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 85Combined sources
Helixi15 – 2612Combined sources
Helixi45 – 5511Combined sources
Helixi69 – 8315Combined sources
Helixi89 – 913Combined sources
Beta strandi92 – 965Combined sources
Helixi97 – 10913Combined sources
Beta strandi115 – 1217Combined sources
Helixi126 – 1327Combined sources
Beta strandi136 – 1416Combined sources
Helixi144 – 1463Combined sources
Helixi152 – 1576Combined sources
Beta strandi163 – 1719Combined sources
Turni173 – 1753Combined sources
Helixi181 – 19414Combined sources
Beta strandi197 – 2015Combined sources
Turni203 – 2064Combined sources
Helixi216 – 2194Combined sources
Beta strandi221 – 2233Combined sources
Beta strandi226 – 2327Combined sources
Turni233 – 2375Combined sources
Helixi239 – 2413Combined sources
Beta strandi244 – 2474Combined sources
Helixi250 – 26314Combined sources
Helixi269 – 27810Combined sources
Helixi284 – 30320Combined sources
Beta strandi312 – 3209Combined sources
Helixi325 – 33612Combined sources
Helixi343 – 3464Combined sources
Beta strandi351 – 3555Combined sources
Helixi360 – 37415Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1O4SX-ray1.90A/B1-377[»]
ProteinModelPortaliQ9X0Y2.
SMRiQ9X0Y2. Positions 1-376.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X0Y2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHM. Bacteria.
COG0436. LUCA.
InParanoidiQ9X0Y2.
KOiK00812.
OMAiYIWVDIS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X0Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSRRISEIP ISKTMELDAK AKALIKKGED VINLTAGEPD FPTPEPVVEE
60 70 80 90 100
AVRFLQKGEV KYTDPRGIYE LREGIAKRIG ERYKKDISPD QVVVTNGAKQ
110 120 130 140 150
ALFNAFMALL DPGDEVIVFS PVWVSYIPQI ILAGGTVNVV ETFMSKNFQP
160 170 180 190 200
SLEEVEGLLV GKTKAVLINS PNNPTGVVYR REFLEGLVRL AKKRNFYIIS
210 220 230 240 250
DEVYDSLVYT DEFTSILDVS EGFDRIVYIN GFSKSHSMTG WRVGYLISSE
260 270 280 290 300
KVATAVSKIQ SHTTSCINTV AQYAALKALE VDNSYMVQTF KERKNFVVER
310 320 330 340 350
LKKMGVKFVE PEGAFYLFFK VRGDDVKFCE RLLEEKKVAL VPGSAFLKPG
360 370
FVRLSFATSI ERLTEALDRI EDFLNSR
Length:377
Mass (Da):42,421
Last modified:November 1, 1999 - v1
Checksum:i4EB507704C45E221
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36330.1.
PIRiB72275.
RefSeqiNP_229060.1. NC_000853.1.
WP_004080007.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36330; AAD36330; TM_1255.
GeneIDi898228.
KEGGitma:TM1255.
tmi:THEMA_08060.
tmw:THMA_1280.
PATRICi23937450. VBITheMar51294_1271.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36330.1.
PIRiB72275.
RefSeqiNP_229060.1. NC_000853.1.
WP_004080007.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1O4SX-ray1.90A/B1-377[»]
ProteinModelPortaliQ9X0Y2.
SMRiQ9X0Y2. Positions 1-376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1255.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36330; AAD36330; TM_1255.
GeneIDi898228.
KEGGitma:TM1255.
tmi:THEMA_08060.
tmw:THMA_1280.
PATRICi23937450. VBITheMar51294_1271.

Phylogenomic databases

eggNOGiENOG4105CHM. Bacteria.
COG0436. LUCA.
InParanoidiQ9X0Y2.
KOiK00812.
OMAiYIWVDIS.

Miscellaneous databases

EvolutionaryTraceiQ9X0Y2.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAAT_THEMA
AccessioniPrimary (citable) accession number: Q9X0Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.