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Q9X0X7

- PUR2_THEMA

UniProt

Q9X0X7 - PUR2_THEMA

Protein

Phosphoribosylamine--glycine ligase

Gene

purD

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
    Metal bindingi275 – 2751Magnesium or manganeseUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi125 – 18662ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. manganese ion binding Source: UniProtKB-HAMAP
    4. phosphoribosylamine-glycine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
    2. purine nucleobase biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTMAR243274:GC6P-1281-MONOMER.
    UniPathwayiUPA00074; UER00125.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylamine--glycine ligaseUniRule annotation (EC:6.3.4.13UniRule annotation)
    Alternative name(s):
    GARSUniRule annotation
    Glycinamide ribonucleotide synthetaseUniRule annotation
    Phosphoribosylglycinamide synthetaseUniRule annotation
    Gene namesi
    Name:purDUniRule annotation
    Ordered Locus Names:TM_1250
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 400400Phosphoribosylamine--glycine ligasePRO_0000151495Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243274.TM1250.

    Structurei

    Secondary structure

    1
    400
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 106
    Helixi13 – 2412
    Beta strandi28 – 336
    Helixi38 – 403
    Beta strandi42 – 443
    Helixi50 – 545
    Helixi67 – 693
    Beta strandi81 – 833
    Helixi86 – 938
    Helixi95 – 10410
    Beta strandi112 – 1176
    Helixi118 – 1258
    Beta strandi130 – 1389
    Beta strandi145 – 1506
    Helixi151 – 16212
    Beta strandi165 – 1673
    Beta strandi174 – 1785
    Beta strandi182 – 19211
    Beta strandi195 – 1984
    Beta strandi207 – 2093
    Turni210 – 2123
    Beta strandi213 – 2164
    Beta strandi220 – 2245
    Helixi230 – 24920
    Beta strandi255 – 26511
    Beta strandi268 – 27710
    Helixi282 – 2898
    Helixi291 – 30313
    Beta strandi314 – 3229
    Turni324 – 3285
    Beta strandi344 – 3529
    Beta strandi355 – 3584
    Beta strandi360 – 37213
    Helixi373 – 38614

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1VKZX-ray2.30A/B1-400[»]
    ProteinModelPortaliQ9X0X7.
    SMRiQ9X0X7. Positions 4-399.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9X0X7.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini99 – 303205ATP-graspUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GARS family.UniRule annotation
    Contains 1 ATP-grasp domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0151.
    KOiK01945.
    OMAiYKGFLYA.
    OrthoDBiEOG69SKD1.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    3.90.600.10. 1 hit.
    HAMAPiMF_00138. GARS.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR020561. PRibGlycinamid_synth_ATP-grasp.
    IPR000115. PRibGlycinamide_synth.
    IPR020560. PRibGlycinamide_synth_C-dom.
    IPR020559. PRibGlycinamide_synth_CS.
    IPR020562. PRibGlycinamide_synth_N.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view]
    PfamiPF01071. GARS_A. 1 hit.
    PF02843. GARS_C. 1 hit.
    PF02844. GARS_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR00877. purD. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS00184. GARS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9X0X7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAVRVHILG SGGREHAIGW AFAKQGYEVH FYPGNAGTKR DGTNHPYEGE    50
    KTLKAIPEED IVIPGSEEFL VEGVSNWRSN VFGPVKEVAR LEGSKVYAKR 100
    FMKKYGIRTA RFEVAETPEE LREKIKKFSP PYVIKADGLA RGKGVLILDS 150
    KEETIEKGSK LIIGELIKGV KGPVVIDEFL AGNELSAMAV VNGRNFVILP 200
    FVRDYKRLMD GDRGPNTGGM GSWGPVEIPS DTIKKIEELF DKTLWGVEKE 250
    GYAYRGFLYL GLMLHDGDPY ILEYNVRLGD PETEVIVTLN PEGFVNAVLE 300
    GYRGGKMEPV EPRGFAVDVV LAARGYPDAP EKGKEITLPE EGLIFFAGVA 350
    EKDGKLVTNG GRVLHCMGTG ETKEEARRKA YELAEKVHFE GKTYRRDIAL 400
    Length:400
    Mass (Da):44,326
    Last modified:November 1, 1999 - v1
    Checksum:i411CE014DD7DE90F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36325.1.
    PIRiD72277.
    RefSeqiNP_229055.1. NC_000853.1.
    WP_010865290.1. NC_023151.1.
    YP_008991653.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD36325; AAD36325; TM_1250.
    GeneIDi898233.
    KEGGitma:TM1250.
    tmi:THEMA_08085.
    PATRICi23937440. VBITheMar51294_1266.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36325.1 .
    PIRi D72277.
    RefSeqi NP_229055.1. NC_000853.1.
    WP_010865290.1. NC_023151.1.
    YP_008991653.1. NC_023151.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1VKZ X-ray 2.30 A/B 1-400 [» ]
    ProteinModelPortali Q9X0X7.
    SMRi Q9X0X7. Positions 4-399.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243274.TM1250.

    Protocols and materials databases

    DNASUi 898233.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD36325 ; AAD36325 ; TM_1250 .
    GeneIDi 898233.
    KEGGi tma:TM1250.
    tmi:THEMA_08085.
    PATRICi 23937440. VBITheMar51294_1266.

    Phylogenomic databases

    eggNOGi COG0151.
    KOi K01945.
    OMAi YKGFLYA.
    OrthoDBi EOG69SKD1.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00125 .
    BioCyci TMAR243274:GC6P-1281-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9X0X7.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    3.90.600.10. 1 hit.
    HAMAPi MF_00138. GARS.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR020561. PRibGlycinamid_synth_ATP-grasp.
    IPR000115. PRibGlycinamide_synth.
    IPR020560. PRibGlycinamide_synth_C-dom.
    IPR020559. PRibGlycinamide_synth_CS.
    IPR020562. PRibGlycinamide_synth_N.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view ]
    Pfami PF01071. GARS_A. 1 hit.
    PF02843. GARS_C. 1 hit.
    PF02844. GARS_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR00877. purD. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS00184. GARS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

    Entry informationi

    Entry nameiPUR2_THEMA
    AccessioniPrimary (citable) accession number: Q9X0X7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3