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Q9X0X6

- PUR9_THEMA

UniProt

Q9X0X6 - PUR9_THEMA

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-EC
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurH
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
    Alternative name(s):
    AICAR transformylase
    IMP cyclohydrolase (EC:3.5.4.10)
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
    Gene namesi
    Name:purH
    Ordered Locus Names:TM_1249
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452Bifunctional purine biosynthesis protein PurHPRO_0000192142Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243274.TM1249.

    Structurei

    Secondary structure

    1
    452
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 75
    Helixi12 – 143
    Helixi15 – 239
    Beta strandi27 – 304
    Helixi32 – 409
    Helixi48 – 514
    Helixi57 – 604
    Turni61 – 644
    Helixi67 – 748
    Beta strandi75 – 773
    Beta strandi81 – 855
    Helixi96 – 10611
    Turni107 – 1104
    Beta strandi112 – 1143
    Helixi117 – 1259
    Helixi129 – 15426
    Beta strandi158 – 1658
    Beta strandi172 – 1743
    Beta strandi179 – 1835
    Beta strandi186 – 1905
    Beta strandi192 – 1943
    Helixi198 – 21215
    Beta strandi215 – 2239
    Beta strandi226 – 2327
    Helixi236 – 24611
    Turni247 – 2537
    Beta strandi254 – 2607
    Helixi264 – 2696
    Beta strandi274 – 2785
    Helixi284 – 2907
    Beta strandi296 – 3005
    Beta strandi306 – 3116
    Beta strandi314 – 3196
    Beta strandi328 – 3325
    Helixi337 – 35216
    Beta strandi358 – 3625
    Beta strandi365 – 3706
    Helixi376 – 38712
    Helixi388 – 3914
    Beta strandi395 – 4006
    Helixi405 – 4139
    Beta strandi418 – 4214
    Helixi428 – 43811
    Beta strandi441 – 4444

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ZCZX-ray1.88A/B1-452[»]
    ProteinModelPortaliQ9X0X6.
    SMRiQ9X0X6. Positions 1-452.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9X0X6.

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.By similarity

    Sequence similaritiesi

    Belongs to the PurH family.Curated

    Phylogenomic databases

    eggNOGiCOG0138.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9X0X6-1 [UniParc]FASTAAdd to Basket

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    MKRILVSLYE KEKYLDILRE LHEKGWEIWA SSGTAKFLKS NGIEANDVST    50
    ITGFENLLGG LVKTLHPEIF AGILGPEPRW DVVFVDLYPP PDIDIGGVAL 100
    LRAAAKNWKK VKPAFDMETL KLAIEIDDEE TRKYLAGMTF AFTSVYDSIR 150
    ANQFVEGISL AFKREDLQLR YGENPHEKAF VYGKPAFEIL HEGKTISFNN 200
    ILDAENAWFM AKNLPRMGAV VVKHQSPCGA AIGEDKVEIV KKAIEADDES 250
    SFGGILAVNF EMDEEVAKSL KKYLEVIVAP SFTQEAIEVL SKKKVRLLKP 300
    GDYASWAGKM AFGSLVLSER KYPEGNFELV VGEPLSEKEL EDLEFAYRVV 350
    EGAKSNAVLI AKDGVTVGIG SGQPSRKRAA WIATVMAGEK AKGAVAASDA 400
    FFPFPDSLEI LAQAGVKAVV APLGSIRDEE VIEKARELGI TFYKAPSRVF 450
    RH 452
    Length:452
    Mass (Da):49,867
    Last modified:November 1, 1999 - v1
    Checksum:iE4537EF51A5C4469
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36324.1.
    PIRiC72277.
    RefSeqiNP_229054.1. NC_000853.1.
    YP_007977603.1. NC_021214.1.
    YP_008991654.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD36324; AAD36324; TM_1249.
    GeneIDi898234.
    KEGGitma:TM1249.
    tmi:THEMA_08090.
    tmm:Tmari_1254.
    PATRICi23937438. VBITheMar51294_1265.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36324.1 .
    PIRi C72277.
    RefSeqi NP_229054.1. NC_000853.1.
    YP_007977603.1. NC_021214.1.
    YP_008991654.1. NC_023151.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ZCZ X-ray 1.88 A/B 1-452 [» ]
    ProteinModelPortali Q9X0X6.
    SMRi Q9X0X6. Positions 1-452.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243274.TM1249.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD36324 ; AAD36324 ; TM_1249 .
    GeneIDi 898234.
    KEGGi tma:TM1249.
    tmi:THEMA_08090.
    tmm:Tmari_1254.
    PATRICi 23937438. VBITheMar51294_1265.

    Phylogenomic databases

    eggNOGi COG0138.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .

    Miscellaneous databases

    EvolutionaryTracei Q9X0X6.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

    Entry informationi

    Entry nameiPUR9_THEMA
    AccessioniPrimary (citable) accession number: Q9X0X6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3