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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:TM_1249
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Bifunctional purine biosynthesis protein PurHPRO_0000192142Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1249.

Structurei

Secondary structure

452
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 99Combined sources
Turni11 – 144Combined sources
Helixi15 – 239Combined sources
Beta strandi27 – 304Combined sources
Helixi32 – 409Combined sources
Helixi48 – 514Combined sources
Helixi57 – 604Combined sources
Turni61 – 644Combined sources
Helixi67 – 748Combined sources
Beta strandi75 – 773Combined sources
Beta strandi81 – 866Combined sources
Helixi96 – 10611Combined sources
Turni107 – 1104Combined sources
Beta strandi112 – 1143Combined sources
Helixi117 – 1259Combined sources
Helixi129 – 15426Combined sources
Beta strandi158 – 1658Combined sources
Beta strandi172 – 1743Combined sources
Beta strandi179 – 1835Combined sources
Beta strandi186 – 1894Combined sources
Helixi198 – 21215Combined sources
Beta strandi215 – 2239Combined sources
Beta strandi226 – 2327Combined sources
Helixi236 – 24611Combined sources
Turni247 – 2504Combined sources
Beta strandi254 – 2607Combined sources
Helixi264 – 2685Combined sources
Beta strandi274 – 2785Combined sources
Helixi284 – 2929Combined sources
Beta strandi296 – 3005Combined sources
Beta strandi306 – 3116Combined sources
Beta strandi314 – 3196Combined sources
Beta strandi328 – 3336Combined sources
Helixi337 – 35216Combined sources
Beta strandi358 – 3625Combined sources
Beta strandi365 – 3706Combined sources
Helixi376 – 38712Combined sources
Helixi388 – 3914Combined sources
Beta strandi395 – 4006Combined sources
Helixi406 – 4138Combined sources
Beta strandi418 – 4214Combined sources
Helixi428 – 43811Combined sources
Beta strandi441 – 4444Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZCZX-ray1.88A/B1-452[»]
ProteinModelPortaliQ9X0X6.
SMRiQ9X0X6. Positions 1-452.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X0X6.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.By similarity

Sequence similaritiesi

Belongs to the PurH family.Curated

Phylogenomic databases

eggNOGiCOG0138.
InParanoidiQ9X0X6.
KOiK00602.
OMAiPCGVAEG.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X0X6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRILVSLYE KEKYLDILRE LHEKGWEIWA SSGTAKFLKS NGIEANDVST
60 70 80 90 100
ITGFENLLGG LVKTLHPEIF AGILGPEPRW DVVFVDLYPP PDIDIGGVAL
110 120 130 140 150
LRAAAKNWKK VKPAFDMETL KLAIEIDDEE TRKYLAGMTF AFTSVYDSIR
160 170 180 190 200
ANQFVEGISL AFKREDLQLR YGENPHEKAF VYGKPAFEIL HEGKTISFNN
210 220 230 240 250
ILDAENAWFM AKNLPRMGAV VVKHQSPCGA AIGEDKVEIV KKAIEADDES
260 270 280 290 300
SFGGILAVNF EMDEEVAKSL KKYLEVIVAP SFTQEAIEVL SKKKVRLLKP
310 320 330 340 350
GDYASWAGKM AFGSLVLSER KYPEGNFELV VGEPLSEKEL EDLEFAYRVV
360 370 380 390 400
EGAKSNAVLI AKDGVTVGIG SGQPSRKRAA WIATVMAGEK AKGAVAASDA
410 420 430 440 450
FFPFPDSLEI LAQAGVKAVV APLGSIRDEE VIEKARELGI TFYKAPSRVF

RH
Length:452
Mass (Da):49,867
Last modified:November 1, 1999 - v1
Checksum:iE4537EF51A5C4469
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36324.1.
PIRiC72277.
RefSeqiNP_229054.1. NC_000853.1.
YP_007977603.1. NC_021214.1.
YP_008991654.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD36324; AAD36324; TM_1249.
GeneIDi18093464.
898234.
KEGGitma:TM1249.
tmi:THEMA_08090.
PATRICi23937438. VBITheMar51294_1265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36324.1.
PIRiC72277.
RefSeqiNP_229054.1. NC_000853.1.
YP_007977603.1. NC_021214.1.
YP_008991654.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZCZX-ray1.88A/B1-452[»]
ProteinModelPortaliQ9X0X6.
SMRiQ9X0X6. Positions 1-452.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1249.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36324; AAD36324; TM_1249.
GeneIDi18093464.
898234.
KEGGitma:TM1249.
tmi:THEMA_08090.
PATRICi23937438. VBITheMar51294_1265.

Phylogenomic databases

eggNOGiCOG0138.
InParanoidiQ9X0X6.
KOiK00602.
OMAiPCGVAEG.
OrthoDBiEOG6QCDFF.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Miscellaneous databases

EvolutionaryTraceiQ9X0X6.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiPUR9_THEMA
AccessioniPrimary (citable) accession number: Q9X0X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: February 4, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.