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Q9X0X6

- PUR9_THEMA

UniProt

Q9X0X6 - PUR9_THEMA

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-EC
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:TM_1249
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Bifunctional purine biosynthesis protein PurHPRO_0000192142Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1249.

Structurei

Secondary structure

1
452
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 75
Helixi12 – 143
Helixi15 – 239
Beta strandi27 – 304
Helixi32 – 409
Helixi48 – 514
Helixi57 – 604
Turni61 – 644
Helixi67 – 748
Beta strandi75 – 773
Beta strandi81 – 855
Helixi96 – 10611
Turni107 – 1104
Beta strandi112 – 1143
Helixi117 – 1259
Helixi129 – 15426
Beta strandi158 – 1658
Beta strandi172 – 1743
Beta strandi179 – 1835
Beta strandi186 – 1905
Beta strandi192 – 1943
Helixi198 – 21215
Beta strandi215 – 2239
Beta strandi226 – 2327
Helixi236 – 24611
Turni247 – 2537
Beta strandi254 – 2607
Helixi264 – 2696
Beta strandi274 – 2785
Helixi284 – 2907
Beta strandi296 – 3005
Beta strandi306 – 3116
Beta strandi314 – 3196
Beta strandi328 – 3325
Helixi337 – 35216
Beta strandi358 – 3625
Beta strandi365 – 3706
Helixi376 – 38712
Helixi388 – 3914
Beta strandi395 – 4006
Helixi405 – 4139
Beta strandi418 – 4214
Helixi428 – 43811
Beta strandi441 – 4444

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZCZX-ray1.88A/B1-452[»]
ProteinModelPortaliQ9X0X6.
SMRiQ9X0X6. Positions 1-452.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X0X6.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.By similarity

Sequence similaritiesi

Belongs to the PurH family.Curated

Phylogenomic databases

eggNOGiCOG0138.
InParanoidiQ9X0X6.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X0X6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRILVSLYE KEKYLDILRE LHEKGWEIWA SSGTAKFLKS NGIEANDVST
60 70 80 90 100
ITGFENLLGG LVKTLHPEIF AGILGPEPRW DVVFVDLYPP PDIDIGGVAL
110 120 130 140 150
LRAAAKNWKK VKPAFDMETL KLAIEIDDEE TRKYLAGMTF AFTSVYDSIR
160 170 180 190 200
ANQFVEGISL AFKREDLQLR YGENPHEKAF VYGKPAFEIL HEGKTISFNN
210 220 230 240 250
ILDAENAWFM AKNLPRMGAV VVKHQSPCGA AIGEDKVEIV KKAIEADDES
260 270 280 290 300
SFGGILAVNF EMDEEVAKSL KKYLEVIVAP SFTQEAIEVL SKKKVRLLKP
310 320 330 340 350
GDYASWAGKM AFGSLVLSER KYPEGNFELV VGEPLSEKEL EDLEFAYRVV
360 370 380 390 400
EGAKSNAVLI AKDGVTVGIG SGQPSRKRAA WIATVMAGEK AKGAVAASDA
410 420 430 440 450
FFPFPDSLEI LAQAGVKAVV APLGSIRDEE VIEKARELGI TFYKAPSRVF

RH
Length:452
Mass (Da):49,867
Last modified:November 1, 1999 - v1
Checksum:iE4537EF51A5C4469
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36324.1.
PIRiC72277.
RefSeqiNP_229054.1. NC_000853.1.
YP_007977603.1. NC_021214.1.
YP_008991654.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD36324; AAD36324; TM_1249.
GeneIDi18093464.
898234.
KEGGitma:TM1249.
tmi:THEMA_08090.
tmm:Tmari_1254.
PATRICi23937438. VBITheMar51294_1265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36324.1 .
PIRi C72277.
RefSeqi NP_229054.1. NC_000853.1.
YP_007977603.1. NC_021214.1.
YP_008991654.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ZCZ X-ray 1.88 A/B 1-452 [» ]
ProteinModelPortali Q9X0X6.
SMRi Q9X0X6. Positions 1-452.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM1249.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD36324 ; AAD36324 ; TM_1249 .
GeneIDi 18093464.
898234.
KEGGi tma:TM1249.
tmi:THEMA_08090.
tmm:Tmari_1254.
PATRICi 23937438. VBITheMar51294_1265.

Phylogenomic databases

eggNOGi COG0138.
InParanoidi Q9X0X6.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .

Miscellaneous databases

EvolutionaryTracei Q9X0X6.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiPUR9_THEMA
AccessioniPrimary (citable) accession number: Q9X0X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3