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Protein

Methylglyoxal synthase

Gene

mgsA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Glycerone phosphate = methylglyoxal + phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
Methylglyoxal synthaseUniRule annotation (EC:4.2.3.3UniRule annotation)
Short name:
MGSUniRule annotation
Gene namesi
Name:mgsAUniRule annotation
Ordered Locus Names:TM_1185
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001786481 – 155Methylglyoxal synthaseAdd BLAST155

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1185.

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 11Combined sources6
Helixi13 – 15Combined sources3
Helixi16 – 25Combined sources10
Helixi27 – 30Combined sources4
Beta strandi33 – 37Combined sources5
Helixi39 – 49Combined sources11
Helixi59 – 61Combined sources3
Helixi63 – 72Combined sources10
Beta strandi78 – 82Combined sources5
Beta strandi85 – 87Combined sources3
Helixi95 – 104Combined sources10
Beta strandi109 – 112Combined sources4
Helixi113 – 121Combined sources9
Helixi123 – 126Combined sources4
Beta strandi129 – 134Combined sources6
Helixi136 – 148Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VMDX-ray2.06A/B1-155[»]
ProteinModelPortaliQ9X0R7.
SMRiQ9X0R7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X0R7.

Family & Domainsi

Sequence similaritiesi

Belongs to the methylglyoxal synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z5K. Bacteria.
COG1803. LUCA.
InParanoidiQ9X0R7.
KOiK01734.
OMAiMTPQPHE.

Family and domain databases

CDDicd01422. MGS. 1 hit.
Gene3Di3.40.50.1380. 1 hit.
HAMAPiMF_00549. Methylglyoxal_synth. 1 hit.
InterProiIPR004363. Methylgl_synth.
IPR018148. Methylglyoxal_synth_AS.
IPR011607. MGS-like_dom.
[Graphical view]
PfamiPF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF006614. Methylglyox_syn. 1 hit.
SMARTiSM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
TIGRFAMsiTIGR00160. MGSA. 1 hit.
PROSITEiPS01335. METHYLGLYOXAL_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X0R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKKKRIALI AHDRRKRDLL EWVSFNLGTL SKHELYATGT TGALLQEKLG
60 70 80 90 100
LKVHRLKSGP LGGDQQIGAM IAEGKIDVLI FFWDPLEPQA HDVDVKALIR
110 120 130 140 150
IATVYNIPVA ITRSTADFLI SSPLMNDVYE KIQIDYEEEL ERRIRKVVEG

EEEET
Length:155
Mass (Da):17,641
Last modified:March 27, 2002 - v2
Checksum:iA60A600F5D144205
GO

Sequence cautioni

The sequence AAD36260 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36260.1. Different initiation.
PIRiG72284.
RefSeqiNP_228990.1. NC_000853.1.

Genome annotation databases

EnsemblBacteriaiAAD36260; AAD36260; TM_1185.
GeneIDi898300.
KEGGitma:TM1185.
PATRICi23937310. VBITheMar51294_1203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36260.1. Different initiation.
PIRiG72284.
RefSeqiNP_228990.1. NC_000853.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VMDX-ray2.06A/B1-155[»]
ProteinModelPortaliQ9X0R7.
SMRiQ9X0R7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1185.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36260; AAD36260; TM_1185.
GeneIDi898300.
KEGGitma:TM1185.
PATRICi23937310. VBITheMar51294_1203.

Phylogenomic databases

eggNOGiENOG4108Z5K. Bacteria.
COG1803. LUCA.
InParanoidiQ9X0R7.
KOiK01734.
OMAiMTPQPHE.

Miscellaneous databases

EvolutionaryTraceiQ9X0R7.

Family and domain databases

CDDicd01422. MGS. 1 hit.
Gene3Di3.40.50.1380. 1 hit.
HAMAPiMF_00549. Methylglyoxal_synth. 1 hit.
InterProiIPR004363. Methylgl_synth.
IPR018148. Methylglyoxal_synth_AS.
IPR011607. MGS-like_dom.
[Graphical view]
PfamiPF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF006614. Methylglyox_syn. 1 hit.
SMARTiSM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
TIGRFAMsiTIGR00160. MGSA. 1 hit.
PROSITEiPS01335. METHYLGLYOXAL_SYNTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMGSA_THEMA
AccessioniPrimary (citable) accession number: Q9X0R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: November 2, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.