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Protein

Methylglyoxal synthase

Gene

mgsA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.UniRule annotation

Catalytic activityi

Glycerone phosphate = methylglyoxal + phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12SubstrateUniRule annotation1
Binding sitei16SubstrateUniRule annotation1
Active sitei64Proton donor/acceptorUniRule annotation1
Binding sitei91SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Names & Taxonomyi

Protein namesi
Recommended name:
Methylglyoxal synthaseUniRule annotation (EC:4.2.3.3UniRule annotation)
Short name:
MGSUniRule annotation
Gene namesi
Name:mgsAUniRule annotation
Ordered Locus Names:TM_1185
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001786481 – 155Methylglyoxal synthaseAdd BLAST155

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1185

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 11Combined sources6
Helixi13 – 15Combined sources3
Helixi16 – 25Combined sources10
Helixi27 – 30Combined sources4
Beta strandi33 – 37Combined sources5
Helixi39 – 49Combined sources11
Helixi59 – 61Combined sources3
Helixi63 – 72Combined sources10
Beta strandi78 – 82Combined sources5
Beta strandi85 – 87Combined sources3
Helixi95 – 104Combined sources10
Beta strandi109 – 112Combined sources4
Helixi113 – 121Combined sources9
Helixi123 – 126Combined sources4
Beta strandi129 – 134Combined sources6
Helixi136 – 148Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VMDX-ray2.06A/B1-155[»]
ProteinModelPortaliQ9X0R7
SMRiQ9X0R7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X0R7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 155MGS-likeUniRule annotationAdd BLAST155

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni38 – 41Substrate bindingUniRule annotation4
Regioni58 – 59Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the methylglyoxal synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z5K Bacteria
COG1803 LUCA
InParanoidiQ9X0R7
KOiK01734
OMAiRACDVHN

Family and domain databases

CDDicd01422 MGS, 1 hit
Gene3Di3.40.50.1380, 1 hit
HAMAPiMF_00549 Methylglyoxal_synth, 1 hit
InterProiView protein in InterPro
IPR004363 Methylgl_synth
IPR018148 Methylglyoxal_synth_AS
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
PANTHERiPTHR30492 PTHR30492, 1 hit
PfamiView protein in Pfam
PF02142 MGS, 1 hit
PIRSFiPIRSF006614 Methylglyox_syn, 1 hit
SMARTiView protein in SMART
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
TIGRFAMsiTIGR00160 MGSA, 1 hit
PROSITEiView protein in PROSITE
PS01335 METHYLGLYOXAL_SYNTH, 1 hit
PS51855 MGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9X0R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKKKRIALI AHDRRKRDLL EWVSFNLGTL SKHELYATGT TGALLQEKLG
60 70 80 90 100
LKVHRLKSGP LGGDQQIGAM IAEGKIDVLI FFWDPLEPQA HDVDVKALIR
110 120 130 140 150
IATVYNIPVA ITRSTADFLI SSPLMNDVYE KIQIDYEEEL ERRIRKVVEG

EEEET
Length:155
Mass (Da):17,641
Last modified:March 27, 2002 - v2
Checksum:iA60A600F5D144205
GO

Sequence cautioni

The sequence AAD36260 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA Translation: AAD36260.1 Different initiation.
PIRiG72284
RefSeqiNP_228990.1, NC_000853.1

Genome annotation databases

EnsemblBacteriaiAAD36260; AAD36260; TM_1185
GeneIDi898300
KEGGitma:TM1185

Similar proteinsi

Entry informationi

Entry nameiMGSA_THEMA
AccessioniPrimary (citable) accession number: Q9X0R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: March 28, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health