Reviewed, UniProtKB/Swiss-Prot Q9X0N9 (G6PD_THEMA)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:	zwf
Ordered Locus Names:	TM_1155

Organism

Thermotoga maritima [Complete proteome] [HAMAP]

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	496 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 496	496	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068136
Sites
	Active site	245	1	Proton acceptor By similarity
	Binding site	33	1	NADP By similarity
	Binding site	65	1	NADP By similarity
	Binding site	183	1	Substrate By similarity
	Binding site	187	1	Substrate By similarity
	Binding site	350	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9X0N9-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 572106FCE08F20E8	FASTA	496	57,536
	10 20 30 40 50 60 MKCSLGLEKC PDDTLRCFPK IEQPFGIVIF GASGDLTKRK LIPALNRLFE AGILPERFFV 70 80 90 100 110 120 LGAARTKMDD KKFRSRFDAN PDFLEHCSYI SVDYQDPESF KQLKNTIETL IKRIDSSNLV 130 140 150 160 170 180 FYLAVPPDLY IPILENLSKT GLNEKPARVV IEKPFGKDLE SARRLEDTLQ KYFQEDQIFR 190 200 210 220 230 240 IDHYLGKETV QNILVFRFAN FIFEEIWNNK FVDHVQITMA EDIGVEHRAG YFENVGLLRD 250 260 270 280 290 300 IFQNHMLQIL ALIAMEPPSS FNGENFRNER VKLLRSIRPF PVEELESWIV RGQYGRGVVN 310 320 330 340 350 360 GKEVPAYREE PGVAKDSNVE TFVAMKLFID NWRWSGVPFY LRSGKRLPKK ITEVAVVFKK 370 380 390 400 410 420 IPHSIFAGVP SDELEPNTIV FTLQPNEGIS LEFQVKRPCP GMFPQLLSMD FRYEDYFGVK 430 440 450 460 470 480 LPDAYERLLL DVILGDPTLF MRRDDLEVSW ELLDPVLKAW ENDPVRFSPY VYPAGTWGPR 490 EADLLIERDG RKWRKL

References

[1]

"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000512 Genomic DNA. Translation: AAD36231.1.
PIR	G72289.
RefSeq	NP_228961.1.
3D structure databases
SMR	Q9X0N9. Positions 22-494.
ModBase	Search...
Genome annotation databases
GeneID	898331.
GenomeReviews	Gene locus TM_1155 in contig AE000512_GR.
KEGG	tma:TM1155.
NMPDR	fig|243274.1.peg.1145.
TIGR	TM_1155.
Phylogenomic databases
HOGENOM	HBG322449.
OMA	IRFGSKV.
Enzyme and pathway databases
BioCyc	TMAR243274:TM_1155-MONOMER.
BRENDA	1.1.1.49. 16699.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DH. IPR019796. Glc-6-P_DH_AS. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_THEMA

Accession

Primary (citable) accession number: Q9X0N9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	February 9, 2010
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)