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Q9X0N9

- G6PD_THEMA

UniProt

Q9X0N9 - G6PD_THEMA

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Protein
Glucose-6-phosphate 1-dehydrogenase
Gene
zwf, TM_1155
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei65 – 651NADP By similarity
Binding sitei153 – 1531NADP By similarity
Binding sitei183 – 1831Substrate By similarity
Binding sitei187 – 1871Substrate By similarity
Binding sitei221 – 2211Substrate By similarity
Binding sitei240 – 2401Substrate By similarity
Active sitei245 – 2451Proton acceptor By similarity
Binding sitei345 – 3451Substrate By similarity
Binding sitei350 – 3501Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 388NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: UniProtKB-HAMAP
  2. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

SABIO-RKiQ9X0N9.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:zwf
Ordered Locus Names:TM_1155
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Glucose-6-phosphate 1-dehydrogenaseUniRule annotation
PRO_0000068136Add
BLAST

Proteomic databases

PRIDEiQ9X0N9.

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1155.

Structurei

3D structure databases

ProteinModelPortaliQ9X0N9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
KOiK00036.
OMAiHAFTESS.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X0N9-1 [UniParc]FASTAAdd to Basket

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MKCSLGLEKC PDDTLRCFPK IEQPFGIVIF GASGDLTKRK LIPALNRLFE    50
AGILPERFFV LGAARTKMDD KKFRSRFDAN PDFLEHCSYI SVDYQDPESF 100
KQLKNTIETL IKRIDSSNLV FYLAVPPDLY IPILENLSKT GLNEKPARVV 150
IEKPFGKDLE SARRLEDTLQ KYFQEDQIFR IDHYLGKETV QNILVFRFAN 200
FIFEEIWNNK FVDHVQITMA EDIGVEHRAG YFENVGLLRD IFQNHMLQIL 250
ALIAMEPPSS FNGENFRNER VKLLRSIRPF PVEELESWIV RGQYGRGVVN 300
GKEVPAYREE PGVAKDSNVE TFVAMKLFID NWRWSGVPFY LRSGKRLPKK 350
ITEVAVVFKK IPHSIFAGVP SDELEPNTIV FTLQPNEGIS LEFQVKRPCP 400
GMFPQLLSMD FRYEDYFGVK LPDAYERLLL DVILGDPTLF MRRDDLEVSW 450
ELLDPVLKAW ENDPVRFSPY VYPAGTWGPR EADLLIERDG RKWRKL 496
Length:496
Mass (Da):57,536
Last modified:November 1, 1999 - v1
Checksum:i572106FCE08F20E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36231.1.
PIRiG72289.
RefSeqiNP_228961.1. NC_000853.1.
YP_007977511.1. NC_021214.1.
YP_008991747.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD36231; AAD36231; TM_1155.
GeneIDi898331.
KEGGitma:TM1155.
tmi:THEMA_08565.
tmm:Tmari_1162.
PATRICi23937247. VBITheMar51294_1172.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36231.1 .
PIRi G72289.
RefSeqi NP_228961.1. NC_000853.1.
YP_007977511.1. NC_021214.1.
YP_008991747.1. NC_023151.1.

3D structure databases

ProteinModelPortali Q9X0N9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243274.TM1155.

Proteomic databases

PRIDEi Q9X0N9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD36231 ; AAD36231 ; TM_1155 .
GeneIDi 898331.
KEGGi tma:TM1155.
tmi:THEMA_08565.
tmm:Tmari_1162.
PATRICi 23937247. VBITheMar51294_1172.

Phylogenomic databases

eggNOGi COG0364.
KOi K00036.
OMAi HAFTESS.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
SABIO-RKi Q9X0N9.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiG6PD_THEMA
AccessioniPrimary (citable) accession number: Q9X0N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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