Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9X0N9

- G6PD_THEMA

UniProt

Q9X0N9 - G6PD_THEMA

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei65 – 651NADPUniRule annotation
    Binding sitei153 – 1531NADPUniRule annotation
    Binding sitei183 – 1831SubstrateUniRule annotation
    Binding sitei187 – 1871SubstrateUniRule annotation
    Binding sitei221 – 2211SubstrateUniRule annotation
    Binding sitei240 – 2401SubstrateUniRule annotation
    Active sitei245 – 2451Proton acceptorUniRule annotation
    Binding sitei345 – 3451SubstrateUniRule annotation
    Binding sitei350 – 3501SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi31 – 388NADPUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    SABIO-RKQ9X0N9.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:TM_1155
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Glucose-6-phosphate 1-dehydrogenasePRO_0000068136Add
    BLAST

    Proteomic databases

    PRIDEiQ9X0N9.

    Interactioni

    Protein-protein interaction databases

    STRINGi243274.TM1155.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9X0N9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0364.
    KOiK00036.
    OMAiHAFTESS.
    OrthoDBiEOG61308Z.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9X0N9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKCSLGLEKC PDDTLRCFPK IEQPFGIVIF GASGDLTKRK LIPALNRLFE    50
    AGILPERFFV LGAARTKMDD KKFRSRFDAN PDFLEHCSYI SVDYQDPESF 100
    KQLKNTIETL IKRIDSSNLV FYLAVPPDLY IPILENLSKT GLNEKPARVV 150
    IEKPFGKDLE SARRLEDTLQ KYFQEDQIFR IDHYLGKETV QNILVFRFAN 200
    FIFEEIWNNK FVDHVQITMA EDIGVEHRAG YFENVGLLRD IFQNHMLQIL 250
    ALIAMEPPSS FNGENFRNER VKLLRSIRPF PVEELESWIV RGQYGRGVVN 300
    GKEVPAYREE PGVAKDSNVE TFVAMKLFID NWRWSGVPFY LRSGKRLPKK 350
    ITEVAVVFKK IPHSIFAGVP SDELEPNTIV FTLQPNEGIS LEFQVKRPCP 400
    GMFPQLLSMD FRYEDYFGVK LPDAYERLLL DVILGDPTLF MRRDDLEVSW 450
    ELLDPVLKAW ENDPVRFSPY VYPAGTWGPR EADLLIERDG RKWRKL 496
    Length:496
    Mass (Da):57,536
    Last modified:November 1, 1999 - v1
    Checksum:i572106FCE08F20E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36231.1.
    PIRiG72289.
    RefSeqiNP_228961.1. NC_000853.1.
    YP_007977511.1. NC_021214.1.
    YP_008991747.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD36231; AAD36231; TM_1155.
    GeneIDi898331.
    KEGGitma:TM1155.
    tmi:THEMA_08565.
    tmm:Tmari_1162.
    PATRICi23937247. VBITheMar51294_1172.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36231.1 .
    PIRi G72289.
    RefSeqi NP_228961.1. NC_000853.1.
    YP_007977511.1. NC_021214.1.
    YP_008991747.1. NC_023151.1.

    3D structure databases

    ProteinModelPortali Q9X0N9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243274.TM1155.

    Proteomic databases

    PRIDEi Q9X0N9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD36231 ; AAD36231 ; TM_1155 .
    GeneIDi 898331.
    KEGGi tma:TM1155.
    tmi:THEMA_08565.
    tmm:Tmari_1162.
    PATRICi 23937247. VBITheMar51294_1172.

    Phylogenomic databases

    eggNOGi COG0364.
    KOi K00036.
    OMAi HAFTESS.
    OrthoDBi EOG61308Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    SABIO-RK Q9X0N9.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

    Entry informationi

    Entry nameiG6PD_THEMA
    AccessioniPrimary (citable) accession number: Q9X0N9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3