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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (TM_0438)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei65NADPUniRule annotation1
Binding sitei153NADPUniRule annotation1
Binding sitei183SubstrateUniRule annotation1
Binding sitei187SubstrateUniRule annotation1
Binding sitei221SubstrateUniRule annotation1
Binding sitei240SubstrateUniRule annotation1
Active sitei245Proton acceptorUniRule annotation1
Binding sitei345SubstrateUniRule annotation1
Binding sitei350SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 38NADPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

SABIO-RKQ9X0N9.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:TM_1155
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000681361 – 496Glucose-6-phosphate 1-dehydrogenaseAdd BLAST496

Proteomic databases

PRIDEiQ9X0N9.

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1155.

Structurei

3D structure databases

ProteinModelPortaliQ9X0N9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D8W. Bacteria.
COG0364. LUCA.
InParanoidiQ9X0N9.
KOiK00036.
OMAiTIFEPIW.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD. 1 hit.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X0N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCSLGLEKC PDDTLRCFPK IEQPFGIVIF GASGDLTKRK LIPALNRLFE
60 70 80 90 100
AGILPERFFV LGAARTKMDD KKFRSRFDAN PDFLEHCSYI SVDYQDPESF
110 120 130 140 150
KQLKNTIETL IKRIDSSNLV FYLAVPPDLY IPILENLSKT GLNEKPARVV
160 170 180 190 200
IEKPFGKDLE SARRLEDTLQ KYFQEDQIFR IDHYLGKETV QNILVFRFAN
210 220 230 240 250
FIFEEIWNNK FVDHVQITMA EDIGVEHRAG YFENVGLLRD IFQNHMLQIL
260 270 280 290 300
ALIAMEPPSS FNGENFRNER VKLLRSIRPF PVEELESWIV RGQYGRGVVN
310 320 330 340 350
GKEVPAYREE PGVAKDSNVE TFVAMKLFID NWRWSGVPFY LRSGKRLPKK
360 370 380 390 400
ITEVAVVFKK IPHSIFAGVP SDELEPNTIV FTLQPNEGIS LEFQVKRPCP
410 420 430 440 450
GMFPQLLSMD FRYEDYFGVK LPDAYERLLL DVILGDPTLF MRRDDLEVSW
460 470 480 490
ELLDPVLKAW ENDPVRFSPY VYPAGTWGPR EADLLIERDG RKWRKL
Length:496
Mass (Da):57,536
Last modified:November 1, 1999 - v1
Checksum:i572106FCE08F20E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36231.1.
PIRiG72289.
RefSeqiNP_228961.1. NC_000853.1.
WP_004080226.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36231; AAD36231; TM_1155.
GeneIDi898331.
KEGGitma:TM1155.
PATRICi23937247. VBITheMar51294_1172.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36231.1.
PIRiG72289.
RefSeqiNP_228961.1. NC_000853.1.
WP_004080226.1. NZ_CP011107.1.

3D structure databases

ProteinModelPortaliQ9X0N9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1155.

Proteomic databases

PRIDEiQ9X0N9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36231; AAD36231; TM_1155.
GeneIDi898331.
KEGGitma:TM1155.
PATRICi23937247. VBITheMar51294_1172.

Phylogenomic databases

eggNOGiENOG4105D8W. Bacteria.
COG0364. LUCA.
InParanoidiQ9X0N9.
KOiK00036.
OMAiTIFEPIW.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.
SABIO-RKQ9X0N9.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD. 1 hit.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PD_THEMA
AccessioniPrimary (citable) accession number: Q9X0N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: October 5, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.