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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi

GO - Molecular functioni

  1. 6-phosphogluconolactonase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-1183-MONOMER.
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:pgl
Synonyms:devB
Ordered Locus Names:TM_1154
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2202206-phosphogluconolactonasePRO_0000090108Add
BLAST

Proteomic databases

PRIDEiQ9X0N8.

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1154.

Structurei

Secondary structure

1
220
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 118Combined sources
Helixi13 – 3119Combined sources
Beta strandi35 – 395Combined sources
Helixi45 – 528Combined sources
Helixi59 – 613Combined sources
Beta strandi62 – 7211Combined sources
Helixi80 – 878Combined sources
Turni88 – 914Combined sources
Helixi96 – 983Combined sources
Helixi108 – 12215Combined sources
Beta strandi127 – 1315Combined sources
Helixi145 – 1484Combined sources
Beta strandi151 – 1566Combined sources
Beta strandi158 – 1603Combined sources
Turni161 – 1644Combined sources
Beta strandi167 – 1704Combined sources
Helixi172 – 1754Combined sources
Beta strandi179 – 1879Combined sources
Helixi188 – 19811Combined sources
Helixi204 – 2074Combined sources
Beta strandi211 – 2199Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PBTX-ray1.70A1-220[»]
1VL1X-ray1.55A1-220[»]
ProteinModelPortaliQ9X0N8.
SMRiQ9X0N8. Positions 1-220.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X0N8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0363.
InParanoidiQ9X0N8.
KOiK01057.
OMAiLFPGQTN.
OrthoDBiEOG63FW46.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X0N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKTVIYLLE DGYVDFVVEK IRTKMEKLLE EKDKIFVVLA GGRTPLPVYE
60 70 80 90 100
KLAEQKFPWN RIHFFLSDER YVPLDSDQSN FRNINEVLFS RAKIPSGNVH
110 120 130 140 150
YVDTSLPIEK ACEKYEREIR SATDQFDLAI LGMGPDGHVA SIFDLETGNK
160 170 180 190 200
DNLVTFTDPS GDPKVPRVTL TFRALNTSLY VLFLIRGKEK INRLTEILKD
210 220
TPLPAYFVRG KEKTVWFVGK
Length:220
Mass (Da):25,325
Last modified:November 1, 1999 - v1
Checksum:i9B0FD07EE01E60C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36230.1.
PIRiF72289.
RefSeqiNP_228960.1. NC_000853.1.
YP_007977510.1. NC_021214.1.
YP_008991748.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD36230; AAD36230; TM_1154.
GeneIDi15494763.
18093562.
898332.
KEGGitma:TM1154.
tmi:THEMA_08570.
PATRICi23937245. VBITheMar51294_1171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36230.1.
PIRiF72289.
RefSeqiNP_228960.1. NC_000853.1.
YP_007977510.1. NC_021214.1.
YP_008991748.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PBTX-ray1.70A1-220[»]
1VL1X-ray1.55A1-220[»]
ProteinModelPortaliQ9X0N8.
SMRiQ9X0N8. Positions 1-220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1154.

Proteomic databases

PRIDEiQ9X0N8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36230; AAD36230; TM_1154.
GeneIDi15494763.
18093562.
898332.
KEGGitma:TM1154.
tmi:THEMA_08570.
PATRICi23937245. VBITheMar51294_1171.

Phylogenomic databases

eggNOGiCOG0363.
InParanoidiQ9X0N8.
KOiK01057.
OMAiLFPGQTN.
OrthoDBiEOG63FW46.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
BioCyciTMAR243274:GC6P-1183-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9X0N8.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry namei6PGL_THEMA
AccessioniPrimary (citable) accession number: Q9X0N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: March 4, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.