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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (TM_0438)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:pgl
Synonyms:devB
Ordered Locus Names:TM_1154
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Pathology & Biotechi

Chemistry databases

DrugBankiDB03754. Tris.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000901081 – 2206-phosphogluconolactonaseAdd BLAST220

Proteomic databases

PRIDEiQ9X0N8.

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1154.

Structurei

Secondary structure

1220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 11Combined sources8
Helixi13 – 31Combined sources19
Beta strandi35 – 39Combined sources5
Helixi45 – 52Combined sources8
Helixi59 – 61Combined sources3
Beta strandi62 – 72Combined sources11
Helixi80 – 87Combined sources8
Turni88 – 91Combined sources4
Helixi96 – 98Combined sources3
Helixi108 – 122Combined sources15
Beta strandi127 – 131Combined sources5
Helixi145 – 148Combined sources4
Beta strandi151 – 156Combined sources6
Beta strandi158 – 160Combined sources3
Turni161 – 164Combined sources4
Beta strandi167 – 170Combined sources4
Helixi172 – 175Combined sources4
Beta strandi179 – 187Combined sources9
Helixi188 – 198Combined sources11
Helixi204 – 207Combined sources4
Beta strandi211 – 219Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PBTX-ray1.70A1-220[»]
1VL1X-ray1.55A1-220[»]
ProteinModelPortaliQ9X0N8.
SMRiQ9X0N8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X0N8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108Q79. Bacteria.
COG0363. LUCA.
InParanoidiQ9X0N8.
KOiK01057.
OMAiEDRASLC.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X0N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKTVIYLLE DGYVDFVVEK IRTKMEKLLE EKDKIFVVLA GGRTPLPVYE
60 70 80 90 100
KLAEQKFPWN RIHFFLSDER YVPLDSDQSN FRNINEVLFS RAKIPSGNVH
110 120 130 140 150
YVDTSLPIEK ACEKYEREIR SATDQFDLAI LGMGPDGHVA SIFDLETGNK
160 170 180 190 200
DNLVTFTDPS GDPKVPRVTL TFRALNTSLY VLFLIRGKEK INRLTEILKD
210 220
TPLPAYFVRG KEKTVWFVGK
Length:220
Mass (Da):25,325
Last modified:November 1, 1999 - v1
Checksum:i9B0FD07EE01E60C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36230.1.
PIRiF72289.
RefSeqiNP_228960.1. NC_000853.1.
WP_008195599.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36230; AAD36230; TM_1154.
GeneIDi898332.
KEGGitma:TM1154.
PATRICi23937245. VBITheMar51294_1171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36230.1.
PIRiF72289.
RefSeqiNP_228960.1. NC_000853.1.
WP_008195599.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PBTX-ray1.70A1-220[»]
1VL1X-ray1.55A1-220[»]
ProteinModelPortaliQ9X0N8.
SMRiQ9X0N8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM1154.

Chemistry databases

DrugBankiDB03754. Tris.

Proteomic databases

PRIDEiQ9X0N8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36230; AAD36230; TM_1154.
GeneIDi898332.
KEGGitma:TM1154.
PATRICi23937245. VBITheMar51294_1171.

Phylogenomic databases

eggNOGiENOG4108Q79. Bacteria.
COG0363. LUCA.
InParanoidiQ9X0N8.
KOiK01057.
OMAiEDRASLC.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.

Miscellaneous databases

EvolutionaryTraceiQ9X0N8.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry namei6PGL_THEMA
AccessioniPrimary (citable) accession number: Q9X0N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.