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Protein

Methyl-accepting chemotaxis protein 2

Gene

mcp2

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-accepting chemotaxis protein 2
Gene namesi
Name:mcp2
Ordered Locus Names:TM_1143
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence analysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Methyl-accepting chemotaxis protein 2PRO_0000250994Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei274 – 2741Glutamate methyl ester (Gln)1 Publication
Modified residuei281 – 2811Glutamate methyl ester (Glu)1 Publication
Modified residuei498 – 4981Deamidated glutamine1 Publication
Modified residuei505 – 5051Glutamate methyl ester (Glu)1 Publication

Keywords - PTMi

Methylation

Interactioni

Protein-protein interaction databases

DIPiDIP-29072N.
STRINGi243274.TM1143.

Structurei

Secondary structure

1
530
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi225 – 341117Combined sources
Helixi344 – 37229Combined sources
Helixi378 – 41437Combined sources
Helixi417 – 43216Combined sources
Helixi435 – 51884Combined sources
Turni520 – 5223Combined sources
Helixi523 – 5286Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CH7X-ray2.50A/B225-529[»]
3JA6electron microscopy12.70G/I/K/M/O/Q225-529[»]
H/J/L/N/P/R225-528[»]
ProteinModelPortaliQ9X0M7.
SMRiQ9X0M7. Positions 222-529.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X0M7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini152 – 22271HAMPAdd
BLAST
Domaini244 – 480237Methyl-accepting transducerPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HAMP domain.Curated
Contains 1 methyl-accepting transducer domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C8Q. Bacteria.
COG0840. LUCA.
InParanoidiQ9X0M7.
KOiK03406.
OMAiNGMHTIN.

Family and domain databases

InterProiIPR004090. Chemotax_Me-accpt_rcpt.
IPR003660. HAMP_dom.
IPR004089. MCPsignal_dom.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
PRINTSiPR00260. CHEMTRNSDUCR.
SMARTiSM00283. MA. 1 hit.
[Graphical view]
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X0M7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKGKTLLV STITLAAVVL VALLGGSVFL KAGQNVRKAF EEYELAVEAL
60 70 80 90 100
DKLGELETKV ALFVNNAAKI EEVSSLFNEL KKVADKIPSL KEHMDALERN
110 120 130 140 150
ISEIISGKTE VVSRIQSSVD QVKEDIMANL DRTRENLDKE ISYSSELIRN
160 170 180 190 200
VLFIVLPIVA VASGVFLFVM ISRSLRLLKP VMEASRSLRN NDLTINIQEA
210 220 230 240 250
KGKDEISTLL NEFKASIEYL RNNLKDVQTE TFSVAESIEE ISKANEEITN
260 270 280 290 300
QLLGISKEMD NISTRIESIS ASVQETTAGS EEISSATKNI ADSAQQAASF
310 320 330 340 350
ADQSTQLAKE AGDALKKVIE VTRMISNSAK DVERVVESFQ KGAEEITSFV
360 370 380 390 400
ETINAIAEQT NLLALNAAIE AARAGEAGRG FAVVADEIRK LAEESQQASE
410 420 430 440 450
NVRRVVNEIR SIAEDAGKVS SEITARVEEG TKLADEADEK LNSIVGAVER
460 470 480 490 500
INEMLQNIAA AIEEQTAAVD EITTAMTENA KNAEEITNSV KEVNARLQEI
510 520 530
SASTEEVTSR VQTIRENVQM LKEIVARYKI
Length:530
Mass (Da):57,929
Last modified:November 1, 1999 - v1
Checksum:iC04149A4F46890CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36219.1.
PIRiC72291.
RefSeqiNP_228949.1. NC_000853.1.
WP_004080253.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD36219; AAD36219; TM_1143.
GeneIDi898621.
KEGGitma:TM1143.
tmi:THEMA_08630.
tmw:THMA_1166.
PATRICi23937221. VBITheMar51294_1159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD36219.1.
PIRiC72291.
RefSeqiNP_228949.1. NC_000853.1.
WP_004080253.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CH7X-ray2.50A/B225-529[»]
3JA6electron microscopy12.70G/I/K/M/O/Q225-529[»]
H/J/L/N/P/R225-528[»]
ProteinModelPortaliQ9X0M7.
SMRiQ9X0M7. Positions 222-529.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29072N.
STRINGi243274.TM1143.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD36219; AAD36219; TM_1143.
GeneIDi898621.
KEGGitma:TM1143.
tmi:THEMA_08630.
tmw:THMA_1166.
PATRICi23937221. VBITheMar51294_1159.

Phylogenomic databases

eggNOGiENOG4105C8Q. Bacteria.
COG0840. LUCA.
InParanoidiQ9X0M7.
KOiK03406.
OMAiNGMHTIN.

Miscellaneous databases

EvolutionaryTraceiQ9X0M7.

Family and domain databases

InterProiIPR004090. Chemotax_Me-accpt_rcpt.
IPR003660. HAMP_dom.
IPR004089. MCPsignal_dom.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
PRINTSiPR00260. CHEMTRNSDUCR.
SMARTiSM00283. MA. 1 hit.
[Graphical view]
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCP2_THEMA
AccessioniPrimary (citable) accession number: Q9X0M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.