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Q9X0L4 (PTAS_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphate acetyltransferase

EC=2.3.1.8
Alternative name(s):
Phosphotransacetylase
Gene names
Name:pta
Ordered Locus Names:TM_1130
OrganismThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [Reference proteome] [HAMAP]
Taxonomic identifier243274 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

In addition to acetyl-CoA (100%), the enzyme accepts propionyl-CoA (60%) and butyryl-CoA (30%).

Catalytic activity

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathway

Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2.

Subunit structure

Homotetramer.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the phosphate acetyltransferase and butyryltransferase family.

Biophysicochemical properties

Temperature dependence:

Optimum temperature is 90 degrees Celsius.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processacetyl-CoA biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphate acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Phosphate acetyltransferase
PRO_0000179149

Experimental info

Sequence conflict111R → Y AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9X0L4 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: F4B98B3CAE120AFB

FASTA29432,093
        10         20         30         40         50         60 
MFLEKLVEMA RGKGKKLAVA AANDDHVIEA VYRAWRERVC EPVLFGPEEE ITRIIEELVP 

        70         80         90        100        110        120 
EWKNPQIIDC PPEEAGRLAV EAVSKGECDF LMKGKIKTGD LMKIYLDERY GLRTGKTMAM 

       130        140        150        160        170        180 
VSVMEIPDFP RPLIISDPGM LISPTLEQKV DMIEHCVRVA NVMGLETPKV AVVGAIEVVN 

       190        200        210        220        230        240 
PKMPITMEAA ILSKMNQRGQ IKGCIVDGPF ALDNVVSEEA AKKKGIQSPV AGKADILILP 

       250        260        270        280        290 
DIEAANILYK ALVFLAKAKS ASTILGGKVP VVLTSRADSE ETKFYSIALS AVFA 

« Hide

References

« Hide 'large scale' references
[1]"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima."
Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. expand/collapse author list , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M.
Nature 399:323-329(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
[2]"Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima."
Bock A.-K., Glasemacher J., Schmidt R., Schoenheit P.
J. Bacteriol. 181:1861-1867(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-39, CHARACTERIZATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000512 Genomic DNA. Translation: AAD36206.1.
PIRG72293.
RefSeqNP_228936.1. NC_000853.1.
YP_007977485.1. NC_021214.1.
YP_008991772.1. NC_023151.1.

3D structure databases

ProteinModelPortalQ9X0L4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-2900N.
STRING243274.TM1130.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD36206; AAD36206; TM_1130.
GeneID15494738.
18093586.
898634.
KEGGtma:TM1130.
tmm:Tmari_1136.
PATRIC23937195. VBITheMar51294_1146.

Phylogenomic databases

eggNOGCOG0280.
KOK00625.
OMANKEYGLR.
OrthoDBEOG60GRZ3.
ProtClustDBCLSK795703.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-427.
UniPathwayUPA00340; UER00459.

Family and domain databases

InterProIPR012147. P_Ac_Bu_trans.
IPR002505. PTA_PTB.
[Graphical view]
PfamPF01515. PTA_PTB. 2 hits.
[Graphical view]
PIRSFPIRSF000428. P_Ac_trans. 1 hit.
ProtoNetSearch...

Entry information

Entry namePTAS_THEMA
AccessionPrimary (citable) accession number: Q9X0L4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: March 19, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways