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Q9X0L4

- PTAS_THEMA

UniProt

Q9X0L4 - PTAS_THEMA

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Protein

Phosphate acetyltransferase

Gene
pta, TM_1130
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

In addition to acetyl-CoA (100%), the enzyme accepts propionyl-CoA (60%) and butyryl-CoA (30%).

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Temperature dependencei

Optimum temperature is 90 degrees Celsius.

Pathwayi

GO - Molecular functioni

  1. phosphate acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-427.
UniPathwayiUPA00340; UER00459.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:TM_1130
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Phosphate acetyltransferasePRO_0000179149Add
BLAST

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

DIPiDIP-2900N.
STRINGi243274.TM1130.

Structurei

3D structure databases

ProteinModelPortaliQ9X0L4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0280.
KOiK00625.
OMAiFEVPNYD.
OrthoDBiEOG60GRZ3.

Family and domain databases

InterProiIPR012147. P_Ac_Bu_trans.
IPR002505. PTA_PTB.
[Graphical view]
PfamiPF01515. PTA_PTB. 2 hits.
[Graphical view]
PIRSFiPIRSF000428. P_Ac_trans. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X0L4-1 [UniParc]FASTAAdd to Basket

« Hide

MFLEKLVEMA RGKGKKLAVA AANDDHVIEA VYRAWRERVC EPVLFGPEEE    50
ITRIIEELVP EWKNPQIIDC PPEEAGRLAV EAVSKGECDF LMKGKIKTGD 100
LMKIYLDERY GLRTGKTMAM VSVMEIPDFP RPLIISDPGM LISPTLEQKV 150
DMIEHCVRVA NVMGLETPKV AVVGAIEVVN PKMPITMEAA ILSKMNQRGQ 200
IKGCIVDGPF ALDNVVSEEA AKKKGIQSPV AGKADILILP DIEAANILYK 250
ALVFLAKAKS ASTILGGKVP VVLTSRADSE ETKFYSIALS AVFA 294
Length:294
Mass (Da):32,093
Last modified:November 1, 1999 - v1
Checksum:iF4B98B3CAE120AFB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111R → Y AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36206.1.
PIRiG72293.
RefSeqiNP_228936.1. NC_000853.1.
WP_004080280.1. NC_023151.1.
YP_007977485.1. NC_021214.1.
YP_008991772.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD36206; AAD36206; TM_1130.
GeneIDi898634.
KEGGitma:TM1130.
tmi:THEMA_08695.
tmm:Tmari_1136.
PATRICi23937195. VBITheMar51294_1146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36206.1 .
PIRi G72293.
RefSeqi NP_228936.1. NC_000853.1.
WP_004080280.1. NC_023151.1.
YP_007977485.1. NC_021214.1.
YP_008991772.1. NC_023151.1.

3D structure databases

ProteinModelPortali Q9X0L4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-2900N.
STRINGi 243274.TM1130.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD36206 ; AAD36206 ; TM_1130 .
GeneIDi 898634.
KEGGi tma:TM1130.
tmi:THEMA_08695.
tmm:Tmari_1136.
PATRICi 23937195. VBITheMar51294_1146.

Phylogenomic databases

eggNOGi COG0280.
KOi K00625.
OMAi FEVPNYD.
OrthoDBi EOG60GRZ3.

Enzyme and pathway databases

UniPathwayi UPA00340 ; UER00459 .
BioCyci MetaCyc:MONOMER-427.

Family and domain databases

InterProi IPR012147. P_Ac_Bu_trans.
IPR002505. PTA_PTB.
[Graphical view ]
Pfami PF01515. PTA_PTB. 2 hits.
[Graphical view ]
PIRSFi PIRSF000428. P_Ac_trans. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  2. "Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima."
    Bock A.-K., Glasemacher J., Schmidt R., Schoenheit P.
    J. Bacteriol. 181:1861-1867(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-39, CHARACTERIZATION.

Entry informationi

Entry nameiPTAS_THEMA
AccessioniPrimary (citable) accession number: Q9X0L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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