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Q9X0L4

- PTAS_THEMA

UniProt

Q9X0L4 - PTAS_THEMA

Protein

Phosphate acetyltransferase

Gene

pta

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    In addition to acetyl-CoA (100%), the enzyme accepts propionyl-CoA (60%) and butyryl-CoA (30%).

    Catalytic activityi

    Acetyl-CoA + phosphate = CoA + acetyl phosphate.

    Temperature dependencei

    Optimum temperature is 90 degrees Celsius.

    Pathwayi

    GO - Molecular functioni

    1. phosphate acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-427.
    UniPathwayiUPA00340; UER00459.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphate acetyltransferase (EC:2.3.1.8)
    Alternative name(s):
    Phosphotransacetylase
    Gene namesi
    Name:pta
    Ordered Locus Names:TM_1130
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294Phosphate acetyltransferasePRO_0000179149Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.

    Protein-protein interaction databases

    DIPiDIP-2900N.
    STRINGi243274.TM1130.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9X0L4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0280.
    KOiK00625.
    OMAiFEVPNYD.
    OrthoDBiEOG60GRZ3.

    Family and domain databases

    InterProiIPR012147. P_Ac_Bu_trans.
    IPR002505. PTA_PTB.
    [Graphical view]
    PfamiPF01515. PTA_PTB. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000428. P_Ac_trans. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9X0L4-1 [UniParc]FASTAAdd to Basket

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    MFLEKLVEMA RGKGKKLAVA AANDDHVIEA VYRAWRERVC EPVLFGPEEE    50
    ITRIIEELVP EWKNPQIIDC PPEEAGRLAV EAVSKGECDF LMKGKIKTGD 100
    LMKIYLDERY GLRTGKTMAM VSVMEIPDFP RPLIISDPGM LISPTLEQKV 150
    DMIEHCVRVA NVMGLETPKV AVVGAIEVVN PKMPITMEAA ILSKMNQRGQ 200
    IKGCIVDGPF ALDNVVSEEA AKKKGIQSPV AGKADILILP DIEAANILYK 250
    ALVFLAKAKS ASTILGGKVP VVLTSRADSE ETKFYSIALS AVFA 294
    Length:294
    Mass (Da):32,093
    Last modified:November 1, 1999 - v1
    Checksum:iF4B98B3CAE120AFB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 111R → Y AA sequence (PubMed:10074080)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36206.1.
    PIRiG72293.
    RefSeqiNP_228936.1. NC_000853.1.
    WP_004080280.1. NC_023151.1.
    YP_007977485.1. NC_021214.1.
    YP_008991772.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD36206; AAD36206; TM_1130.
    GeneIDi898634.
    KEGGitma:TM1130.
    tmi:THEMA_08695.
    tmm:Tmari_1136.
    PATRICi23937195. VBITheMar51294_1146.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36206.1 .
    PIRi G72293.
    RefSeqi NP_228936.1. NC_000853.1.
    WP_004080280.1. NC_023151.1.
    YP_007977485.1. NC_021214.1.
    YP_008991772.1. NC_023151.1.

    3D structure databases

    ProteinModelPortali Q9X0L4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-2900N.
    STRINGi 243274.TM1130.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD36206 ; AAD36206 ; TM_1130 .
    GeneIDi 898634.
    KEGGi tma:TM1130.
    tmi:THEMA_08695.
    tmm:Tmari_1136.
    PATRICi 23937195. VBITheMar51294_1146.

    Phylogenomic databases

    eggNOGi COG0280.
    KOi K00625.
    OMAi FEVPNYD.
    OrthoDBi EOG60GRZ3.

    Enzyme and pathway databases

    UniPathwayi UPA00340 ; UER00459 .
    BioCyci MetaCyc:MONOMER-427.

    Family and domain databases

    InterProi IPR012147. P_Ac_Bu_trans.
    IPR002505. PTA_PTB.
    [Graphical view ]
    Pfami PF01515. PTA_PTB. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000428. P_Ac_trans. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
    2. "Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima."
      Bock A.-K., Glasemacher J., Schmidt R., Schoenheit P.
      J. Bacteriol. 181:1861-1867(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-39, CHARACTERIZATION.

    Entry informationi

    Entry nameiPTAS_THEMA
    AccessioniPrimary (citable) accession number: Q9X0L4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3