Q9X0G6PANC_THEMAPantothenate synthetasePS6.3.2.1Pantoate--beta-alanine ligasePantoate-activating enzymepanCTM_1077Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)BacteriaThermotogotaThermotogaeThermotogalesThermotogaceaeThermotogaEvidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.Homodimer.CytoplasmThe reaction proceeds by a bi uni uni bi ping pong mechanism.Belongs to the pantothenate synthetase family.3D-structureATP-bindingCytoplasmLigaseNucleotide-bindingPantothenate biosynthesisReference proteomeATP(R)-pantoatebeta-alanineATP(R)-pantoateATPATPMRIIETIEEMKKFSEEMREKKKTIGFVPTMGYLHEGHLSLVRRARAENDVVVVSIFVNPTQFGPNEDYERYPRDFERDRKLLEKENVDCIFHPSVEEMYPPDFSTYVEETKLSKHLCGRSRPGHFRGVCTVVTKLFNIVKPHRAYFGQKDAQQFRVLRRMVRDLNMDVEMIECPIVREPDGLAMSSRNVYLSPEERQQALSLYQSLKIAENLYLNGERDAEKIKEEMIKHLSRFDKVKIDYVEIVDEETLEPVEKIDRKVIVAVAAWVGNARLIDNTILG
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