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Q9X0G6

- PANC_THEMA

UniProt

Q9X0G6 - PANC_THEMA

Protein

Pantothenate synthetase

Gene

panC

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei37 – 371Proton donorUniRule annotation
    Binding sitei61 – 611Beta-alanineUniRule annotation
    Binding sitei61 – 611PantoateUniRule annotation
    Binding sitei153 – 1531PantoateUniRule annotation
    Binding sitei176 – 1761ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi30 – 378ATPUniRule annotation
    Nucleotide bindingi147 – 1504ATPUniRule annotation
    Nucleotide bindingi184 – 1874ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:TM_1077
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 280280Pantothenate synthetasePRO_0000128280Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243274.TM1077.

    Structurei

    Secondary structure

    1
    280
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 43
    Helixi7 – 1913
    Beta strandi24 – 296
    Helixi35 – 4713
    Beta strandi48 – 558
    Helixi59 – 613
    Helixi68 – 703
    Helixi75 – 839
    Turni84 – 863
    Beta strandi88 – 914
    Helixi95 – 984
    Helixi112 – 1143
    Turni115 – 1173
    Helixi118 – 1203
    Helixi124 – 13916
    Beta strandi142 – 1476
    Helixi148 – 1503
    Helixi151 – 16313
    Beta strandi169 – 1735
    Helixi186 – 1905
    Helixi193 – 1986
    Helixi201 – 21414
    Helixi220 – 23213
    Beta strandi237 – 24610
    Turni247 – 2493
    Beta strandi260 – 2689
    Beta strandi271 – 2799

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2EJCX-ray2.40A1-280[»]
    ProteinModelPortaliQ9X0G6.
    SMRiQ9X0G6. Positions 1-280.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9X0G6.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    KOiK01918.
    OMAiECPIVRE.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9X0G6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIIETIEEM KKFSEEMREK KKTIGFVPTM GYLHEGHLSL VRRARAENDV    50
    VVVSIFVNPT QFGPNEDYER YPRDFERDRK LLEKENVDCI FHPSVEEMYP 100
    PDFSTYVEET KLSKHLCGRS RPGHFRGVCT VVTKLFNIVK PHRAYFGQKD 150
    AQQFRVLRRM VRDLNMDVEM IECPIVREPD GLAMSSRNVY LSPEERQQAL 200
    SLYQSLKIAE NLYLNGERDA EKIKEEMIKH LSRFDKVKID YVEIVDEETL 250
    EPVEKIDRKV IVAVAAWVGN ARLIDNTILG 280
    Length:280
    Mass (Da):32,757
    Last modified:November 1, 1999 - v1
    Checksum:i0BD1E4C572197163
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36154.1.
    PIRiE72296.
    RefSeqiNP_228883.1. NC_000853.1.
    YP_007977430.1. NC_021214.1.
    YP_008991827.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD36154; AAD36154; TM_1077.
    GeneIDi896992.
    KEGGitma:TM1077.
    tmi:THEMA_08970.
    tmm:Tmari_1081.
    PATRICi23937083. VBITheMar51294_1090.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36154.1 .
    PIRi E72296.
    RefSeqi NP_228883.1. NC_000853.1.
    YP_007977430.1. NC_021214.1.
    YP_008991827.1. NC_023151.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2EJC X-ray 2.40 A 1-280 [» ]
    ProteinModelPortali Q9X0G6.
    SMRi Q9X0G6. Positions 1-280.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243274.TM1077.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD36154 ; AAD36154 ; TM_1077 .
    GeneIDi 896992.
    KEGGi tma:TM1077.
    tmi:THEMA_08970.
    tmm:Tmari_1081.
    PATRICi 23937083. VBITheMar51294_1090.

    Phylogenomic databases

    eggNOGi COG0414.
    KOi K01918.
    OMAi ECPIVRE.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .

    Miscellaneous databases

    EvolutionaryTracei Q9X0G6.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

    Entry informationi

    Entry nameiPANC_THEMA
    AccessioniPrimary (citable) accession number: Q9X0G6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3