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Q9X0D1

- HISX_THEMA

UniProt

Q9X0D1 - HISX_THEMA

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei232 – 2321SubstrateUniRule annotation
Metal bindingi254 – 2541ZincUniRule annotation
Binding sitei254 – 2541SubstrateUniRule annotation
Metal bindingi257 – 2571ZincUniRule annotation
Binding sitei257 – 2571SubstrateUniRule annotation
Active sitei324 – 3241Proton acceptorUniRule annotation
Active sitei325 – 3251Proton acceptorUniRule annotation
Binding sitei325 – 3251SubstrateUniRule annotation
Metal bindingi358 – 3581ZincUniRule annotation
Binding sitei358 – 3581SubstrateUniRule annotation
Binding sitei412 – 4121SubstrateUniRule annotation
Metal bindingi417 – 4171ZincUniRule annotation
Binding sitei417 – 4171SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:TM_1041
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Histidinol dehydrogenasePRO_0000135869Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1041.

Structurei

3D structure databases

ProteinModelPortaliQ9X0D1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
InParanoidiQ9X0D1.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X0D1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MILMNNPGDK EVLRLLKQRM ESVSQVEETV KEIIRRVKEE GDRALEEFLK
60 70 80 90 100
RFEKHPVGIE NLRVTEKEIS EAQVEEEFVE TIKIVIEDLK EFHRRQEERS
110 120 130 140 150
FFFTTKGGSF LGEMVVPLES VGIYVPGGKV PYFSTLLMCA VPAIVAGVER
160 170 180 190 200
IAVTTPPNEN GGISPYILKT CEILGLKEIY RMGGAHAVAA LTYGTETVKP
210 220 230 240 250
VDKIVGPGGV FVTLAKKHVY GDVGIDSIAG PSEIAIVTDG SADLDLIAAD
260 270 280 290 300
FLSQAEHDEN AMSVVITTSK EVFEKLPQVI ERHLEALPEE RRKTARISTE
310 320 330 340 350
NFGTIILTDS LKRAFEISNL IAPEHLEVLV ENPFEPLGHI KNAGSVFLGK
360 370 380 390 400
YTCESVGDYG AGPNHVLPTF RSARFSSGLR VSDFTKKIFI THLSEEDFRR
410 420
KSELYSKMAR WEGFEAHARA IDVRREKL
Length:428
Mass (Da):47,749
Last modified:November 1, 1999 - v1
Checksum:iA7A765F2C298B45C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36118.1.
PIRiH72304.
RefSeqiNP_228847.1. NC_000853.1.
YP_007977394.1. NC_021214.1.
YP_008991863.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD36118; AAD36118; TM_1041.
GeneIDi18093677.
897023.
KEGGitma:TM1041.
tmi:THEMA_09155.
tmm:Tmari_1045.
PATRICi23937011. VBITheMar51294_1054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36118.1 .
PIRi H72304.
RefSeqi NP_228847.1. NC_000853.1.
YP_007977394.1. NC_021214.1.
YP_008991863.1. NC_023151.1.

3D structure databases

ProteinModelPortali Q9X0D1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM1041.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD36118 ; AAD36118 ; TM_1041 .
GeneIDi 18093677.
897023.
KEGGi tma:TM1041.
tmi:THEMA_09155.
tmm:Tmari_1045.
PATRICi 23937011. VBITheMar51294_1054.

Phylogenomic databases

eggNOGi COG0141.
InParanoidi Q9X0D1.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiHISX_THEMA
AccessioniPrimary (citable) accession number: Q9X0D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3