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Q9X0C7

- HIS4_THEMA

UniProt

Q9X0C7 - HIS4_THEMA

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Protein
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Gene
hisA, TM_1037
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei8 – 81Proton acceptor Inferred
Active sitei127 – 1271Proton donor Inferred

GO - Molecular functioni

  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00031; UER00009.

Names & Taxonomyi

Protein namesi
Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene namesi
Name:hisA
Ordered Locus Names:TM_1037
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi8 – 81D → N: Loss of activity. 1 Publication
Mutagenesisi48 – 481H → A: Decrease in activity. 1 Publication
Mutagenesisi51 – 511D → N: Decrease in activity. 1 Publication
Mutagenesisi83 – 831R → N: Decrease in activity. 1 Publication
Mutagenesisi127 – 1271D → N: Almost no activity. 1 Publication
Mutagenesisi164 – 1641T → A: Strong decrease in activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2412411-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseUniRule annotation
PRO_0000142068Add
BLAST

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi243274.TM1037.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 109
Beta strandi13 – 175
Helixi18 – 203
Helixi22 – 243
Beta strandi25 – 306
Helixi32 – 4110
Beta strandi47 – 515
Helixi52 – 576
Helixi63 – 686
Helixi69 – 757
Beta strandi76 – 816
Helixi85 – 939
Beta strandi98 – 1014
Helixi103 – 1075
Helixi111 – 1166
Turni117 – 1193
Beta strandi121 – 1299
Helixi141 – 1444
Helixi146 – 1549
Turni155 – 1573
Beta strandi160 – 1656
Helixi168 – 1714
Helixi177 – 18711
Beta strandi190 – 1967
Helixi200 – 21213
Turni213 – 2153
Beta strandi216 – 2227
Helixi224 – 2274
Helixi233 – 2408

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QO2X-ray1.85A/B1-241[»]
2CFFX-ray2.50A/B1-241[»]
2W79X-ray1.85A/B1-241[»]
ProteinModelPortaliQ9X0C7.
SMRiQ9X0C7. Positions 1-241.

Miscellaneous databases

EvolutionaryTraceiQ9X0C7.

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.

Phylogenomic databases

eggNOGiCOG0106.
KOiK01814.
OMAiKKENTIF.
OrthoDBiEOG6H1Q3W.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01014. HisA.
InterProiIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR006063. HisA.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR00007. TIGR00007. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X0C7-1 [UniParc]FASTAAdd to Basket

« Hide

MLVVPAIDLF RGKVARMIKG RKENTIFYEK DPVELVEKLI EEGFTLIHVV    50
DLSNAIENSG ENLPVLEKLS EFAEHIQIGG GIRSLDYAEK LRKLGYRRQI 100
VSSKVLEDPS FLKSLREIDV EPVFSLDTRG GRVAFKGWLA EEEIDPVSLL 150
KRLKEYGLEE IVHTEIEKDG TLQEHDFSLT KKIAIEAEVK VLAAGGISSE 200
NSLKTAQKVH TETNGLLKGV IVGRAFLEGI LTVEVMKRYA R 241
Length:241
Mass (Da):27,028
Last modified:November 1, 1999 - v1
Checksum:iB1ABDDE5A4D5213D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36114.1.
PIRiD72304.
RefSeqiNP_228843.1. NC_000853.1.
YP_007977390.1. NC_021214.1.
YP_008991867.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD36114; AAD36114; TM_1037.
GeneIDi897150.
KEGGitma:TM1037.
tmi:THEMA_09175.
tmm:Tmari_1041.
PATRICi23937003. VBITheMar51294_1050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36114.1 .
PIRi D72304.
RefSeqi NP_228843.1. NC_000853.1.
YP_007977390.1. NC_021214.1.
YP_008991867.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1QO2 X-ray 1.85 A/B 1-241 [» ]
2CFF X-ray 2.50 A/B 1-241 [» ]
2W79 X-ray 1.85 A/B 1-241 [» ]
ProteinModelPortali Q9X0C7.
SMRi Q9X0C7. Positions 1-241.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM1037.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD36114 ; AAD36114 ; TM_1037 .
GeneIDi 897150.
KEGGi tma:TM1037.
tmi:THEMA_09175.
tmm:Tmari_1041.
PATRICi 23937003. VBITheMar51294_1050.

Phylogenomic databases

eggNOGi COG0106.
KOi K01814.
OMAi KKENTIF.
OrthoDBi EOG6H1Q3W.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00009 .

Miscellaneous databases

EvolutionaryTracei Q9X0C7.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01014. HisA.
InterProi IPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR006063. HisA.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00977. His_biosynth. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR00007. TIGR00007. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  2. "Two (betaalpha)(8)-barrel enzymes of histidine and tryptophan biosynthesis have similar reaction mechanisms and common strategies for protecting their labile substrates."
    Henn-Sax M., Thoma R., Schmidt S., Hennig M., Kirschner K., Sterner R.
    Biochemistry 41:12032-12042(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACTIVE SITES, SUBUNIT, MUTAGENESIS OF ASP-8; HIS-48; ASP-51; ARG-83; ASP-127 AND THR-164.
  3. "Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion."
    Lang D., Thoma R., Henn-Sax M., Sterner R., Wilmanns M.
    Science 289:1546-1550(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).

Entry informationi

Entry nameiHIS4_THEMA
AccessioniPrimary (citable) accession number: Q9X0C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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