ID Q9X0C0_THEMA Unreviewed; 200 AA. AC Q9X0C0; DT 01-NOV-1999, integrated into UniProtKB/TrEMBL. DT 01-NOV-1999, sequence version 1. DT 27-MAR-2024, entry version 155. DE SubName: Full=Transcriptional regulator, TetR family {ECO:0000313|EMBL:AAD36107.1}; GN OrderedLocusNames=TM_1030 {ECO:0000313|EMBL:AAD36107.1}; OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 OS / MSB8). OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Thermotogaceae; OC Thermotoga. OX NCBI_TaxID=243274 {ECO:0000313|EMBL:AAD36107.1, ECO:0000313|Proteomes:UP000008183}; RN [1] {ECO:0000313|EMBL:AAD36107.1, ECO:0000313|Proteomes:UP000008183} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8 RC {ECO:0000313|Proteomes:UP000008183}; RX PubMed=10360571; DOI=10.1038/20601; RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L., RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D., Heidelberg J., RA Sutton G.G., Fleischmann R.D., White O., Salzberg S.L., Smith H.O., RA Venter J.C., Fraser C.M.; RT "Evidence for lateral gene transfer between Archaea and Bacteria from RT genome sequence of Thermotoga maritima."; RL Nature 399:323-329(1999). RN [2] {ECO:0007829|PDB:2ID6} RP X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS). RA Koclega K.D., Chruszcz M., Minor W.; RT "Crystal structure of transcriptional regulator (tm1030) at 1.75A RT resolution."; RL Submitted (SEP-2006) to the PDB data bank. RN [3] {ECO:0007829|PDB:2IEK} RP X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS). RA Koclega K.D., Chruszcz M., Minor W.; RT "New crystal form of transcriptional regulator tm1030 from Thermotoga RT maritima."; RL Submitted (SEP-2006) to the PDB data bank. RN [4] {ECO:0007829|PDB:1Z77} RP X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS). RX PubMed=17588774; DOI=10.1016/j.jsb.2007.04.012; RA Koclega K.D., Chruszcz M., Zimmerman M.D., Cymborowski M., Evdokimova E., RA Minor W.; RT "Crystal structure of a transcriptional regulator TM1030 from Thermotoga RT maritima solved by an unusual MAD experiment."; RL J. Struct. Biol. 159:424-432(2007). RN [5] {ECO:0007829|PDB:1ZKG} RP X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS). RX PubMed=17444523; DOI=10.1002/prot.21436; RA Premkumar L., Rife C.L., Sri Krishna S., McMullan D., Miller M.D., RA Abdubek P., Ambing E., Astakhova T., Axelrod H.L., Canaves J.M., RA Carlton D., Chiu H.J., Clayton T., DiDonato M., Duan L., Elsliger M.A., RA Feuerhelm J., Floyd R., Grzechnik S.K., Hale J., Hampton E., Han G.W., RA Haugen J., Jaroszewski L., Jin K.K., Klock H.E., Knuth M.W., Koesema E., RA Kovarik J.S., Kreusch A., Levin I., McPhillips T.M., Morse A.T., RA Nigoghossian E., Okach L., Oommachen S., Paulsen J., Quijano K., Reyes R., RA Rezezadeh F., Rodionov D., Schwarzenbacher R., Spraggon G., RA van den Bedem H., White A., Wolf G., Xu Q., Hodgson K.O., Wooley J., RA Deacon A.M., Godzik A., Lesley S.A., Wilson I.A.; RT "Crystal structure of TM1030 from Thermotoga maritima at 2.3 A resolution RT reveals molecular details of its transcription repressor function."; RL Proteins 68:418-424(2007). RN [6] {ECO:0007829|PDB:3IH2, ECO:0007829|PDB:3IH3} RP X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS). RX PubMed=20161694; DOI=10.1021/cg900971h; RA Koclega K.D., Chruszcz M., Zimmerman M.D., Bujacz G., Minor W.; RT "'Hot' macromolecular crystals."; RL Cryst. Growth Des. 10:580-580(2009). RN [7] {ECO:0007829|PDB:4I6Z} RP X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS). RA Koclega K.D., Chruszcz M., Cooper D.R., Petkowski J.J., Tkaczuk K.L., RA Joachimiak A., Minor W.; RT "Crystal structure of the transcriptional regulator TM1030 with 24bp DNA RT oligonucleotide."; RL Submitted (NOV-2012) to the PDB data bank. RN [8] {ECO:0007829|PDB:4I76} RP X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS). RA Koclega K.D., Chruszcz M., Cooper D.R., Petkowski J.J., Tkaczuk K.L., RA Joachimiak A., Minor W.; RT "Crystal structure of transcriptional regulator TM1030 with octanol."; RL Submitted (NOV-2012) to the PDB data bank. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE000512; AAD36107.1; -; Genomic_DNA. DR PIR; E72303; E72303. DR RefSeq; NP_228836.1; NC_000853.1. DR RefSeq; WP_010865247.1; NZ_CP011107.1. DR PDB; 1Z77; X-ray; 2.00 A; A=1-200. DR PDB; 1ZKG; X-ray; 2.30 A; A/B=1-200. DR PDB; 2ID6; X-ray; 1.75 A; A=1-200. DR PDB; 2IEK; X-ray; 1.83 A; A=1-200. DR PDB; 3IH2; X-ray; 2.30 A; A=1-200. DR PDB; 3IH3; X-ray; 2.35 A; A=1-200. DR PDB; 3IH4; X-ray; 2.30 A; A=1-200. DR PDB; 4I6Z; X-ray; 3.20 A; A/B=1-200. DR PDB; 4I76; X-ray; 2.10 A; A/B=1-200. DR PDBsum; 1Z77; -. DR PDBsum; 1ZKG; -. DR PDBsum; 2ID6; -. DR PDBsum; 2IEK; -. DR PDBsum; 3IH2; -. DR PDBsum; 3IH3; -. DR PDBsum; 3IH4; -. DR PDBsum; 4I6Z; -. DR PDBsum; 4I76; -. DR AlphaFoldDB; Q9X0C0; -. DR SMR; Q9X0C0; -. DR PaxDb; 243274-THEMA_09210; -. DR EnsemblBacteria; AAD36107; AAD36107; TM_1030. DR KEGG; tma:TM1030; -. DR PATRIC; fig|243274.18.peg.1785; -. DR InParanoid; Q9X0C0; -. DR OrthoDB; 9780939at2; -. DR EvolutionaryTrace; Q9X0C0; -. DR Proteomes; UP000008183; Chromosome. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central. DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1. DR InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR001647; HTH_TetR. DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf. DR InterPro; IPR049488; TM_1030-like_C. DR PANTHER; PTHR30328:SF54; HTH-TYPE TRANSCRIPTIONAL REPRESSOR SCO4008; 1. DR PANTHER; PTHR30328; TRANSCRIPTIONAL REPRESSOR; 1. DR Pfam; PF21256; TetR_C_5-like; 1. DR Pfam; PF00440; TetR_N; 1. DR PRINTS; PR00455; HTHTETR. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1. DR PROSITE; PS01081; HTH_TETR_1; 1. DR PROSITE; PS50977; HTH_TETR_2; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:1Z77, ECO:0007829|PDB:1ZKG}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00335}; Reference proteome {ECO:0000313|Proteomes:UP000008183}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}. FT DOMAIN 2..62 FT /note="HTH tetR-type" FT /evidence="ECO:0000259|PROSITE:PS50977" FT DNA_BIND 25..44 FT /note="H-T-H motif" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335" SQ SEQUENCE 200 AA; 23801 MW; CBF79565CB2D4273 CRC64; MLSKRDAILK AAVEVFGKKG YDRATTDEIA EKAGVAKGLI FHYFKNKEEL YYQAYMSVTE KLQKEFENFL MKNRNRDIFD FMERWIEKKL EYSASHPEEA DFLITLVSVD EGLRKRILLD LEKSQRVFFD FVREKLKDLD LAEDVTEEIA LKFLMWFFSG FEEVYLRTYQ GKPELLKRDM NTLVEEVKVM LRILKKGMTK //