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Q9X0C0

- Q9X0C0_THEMA

UniProt

Q9X0C0 - Q9X0C0_THEMA

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Protein
Submitted name:

TetR family transcriptional regulator

Gene

TM_1030

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851Hexaethylene glycolImported
Binding sitei89 – 891Hexaethylene glycolImported

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-1059-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
TetR family transcriptional regulatorImported
Submitted name:
Transcriptional regulator, TetR familyImported
Gene namesi
Ordered Locus Names:TM_1030Imported
ORF Names:THEMA_09210Imported
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Imported
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi243274.TM1030.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Z77X-ray2.00A1-200[»]
1ZKGX-ray2.30A/B1-200[»]
2ID6X-ray1.75A1-200[»]
2IEKX-ray1.83A1-200[»]
3IH2X-ray2.30A1-200[»]
3IH3X-ray2.35A1-200[»]
3IH4X-ray2.30A1-200[»]
4I6ZX-ray3.20A/B1-200[»]
4I76X-ray2.10A/B1-200[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X0C0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni158 – 1614Hexaethylene glycol bindingImported

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation
Contains HTH tetR-type DNA-binding domain.SAAS annotation

Phylogenomic databases

OMAiMERWIEK.
OrthoDBiEOG6ZH2G9.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
1.10.357.10. 1 hit.
InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X0C0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSKRDAILK AAVEVFGKKG YDRATTDEIA EKAGVAKGLI FHYFKNKEEL
60 70 80 90 100
YYQAYMSVTE KLQKEFENFL MKNRNRDIFD FMERWIEKKL EYSASHPEEA
110 120 130 140 150
DFLITLVSVD EGLRKRILLD LEKSQRVFFD FVREKLKDLD LAEDVTEEIA
160 170 180 190 200
LKFLMWFFSG FEEVYLRTYQ GKPELLKRDM NTLVEEVKVM LRILKKGMTK
Length:200
Mass (Da):23,801
Last modified:November 1, 1999 - v1
Checksum:iCBF79565CB2D4273
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36107.1.
CP007013 Genomic DNA. Translation: AHD19062.1.
PIRiE72303.
RefSeqiNP_228836.1. NC_000853.1.
WP_010865247.1. NC_023151.1.
YP_008991874.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD36107; AAD36107; TM_1030.
GeneIDi18093688.
897092.
KEGGitma:TM1030.
tmi:THEMA_09210.
PATRICi23936989. VBITheMar51294_1043.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD36107.1 .
CP007013 Genomic DNA. Translation: AHD19062.1 .
PIRi E72303.
RefSeqi NP_228836.1. NC_000853.1.
WP_010865247.1. NC_023151.1.
YP_008991874.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Z77 X-ray 2.00 A 1-200 [» ]
1ZKG X-ray 2.30 A/B 1-200 [» ]
2ID6 X-ray 1.75 A 1-200 [» ]
2IEK X-ray 1.83 A 1-200 [» ]
3IH2 X-ray 2.30 A 1-200 [» ]
3IH3 X-ray 2.35 A 1-200 [» ]
3IH4 X-ray 2.30 A 1-200 [» ]
4I6Z X-ray 3.20 A/B 1-200 [» ]
4I76 X-ray 2.10 A/B 1-200 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM1030.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD36107 ; AAD36107 ; TM_1030 .
GeneIDi 18093688.
897092.
KEGGi tma:TM1030.
tmi:THEMA_09210.
PATRICi 23936989. VBITheMar51294_1043.

Phylogenomic databases

OMAi MERWIEK.
OrthoDBi EOG6ZH2G9.

Enzyme and pathway databases

BioCyci TMAR243274:GC6P-1059-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9X0C0.

Family and domain databases

Gene3Di 1.10.10.60. 2 hits.
1.10.357.10. 1 hit.
InterProi IPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view ]
Pfami PF00440. TetR_N. 1 hit.
[Graphical view ]
PRINTSi PR00455. HTHTETR.
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEi PS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099Imported and MSB8Imported.
  2. "Crystal structure of transcriptional regulator (tm1030) at 1.75A resolution."
    Koclega K.D., Chruszcz M., Minor W.
    Submitted (SEP-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS).
  3. "New crystal form of transcriptional regulator tm1030 from Thermotoga maritima."
    Koclega K.D., Chruszcz M., Minor W.
    Submitted (SEP-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS).
  4. "Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment."
    Koclega K.D., Chruszcz M., Zimmerman M.D., Cymborowski M., Evdokimova E., Minor W.
    J. Struct. Biol. 159:424-432(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
  5. "Crystal structure of TM1030 from Thermotoga maritima at 2.3 A resolution reveals molecular details of its transcription repressor function."
    Premkumar L., Rife C.L., Sri Krishna S., McMullan D., Miller M.D., Abdubek P., Ambing E., Astakhova T., Axelrod H.L., Canaves J.M., Carlton D., Chiu H.J., Clayton T., DiDonato M., Duan L., Elsliger M.A., Feuerhelm J., Floyd R.
    , Grzechnik S.K., Hale J., Hampton E., Han G.W., Haugen J., Jaroszewski L., Jin K.K., Klock H.E., Knuth M.W., Koesema E., Kovarik J.S., Kreusch A., Levin I., McPhillips T.M., Morse A.T., Nigoghossian E., Okach L., Oommachen S., Paulsen J., Quijano K., Reyes R., Rezezadeh F., Rodionov D., Schwarzenbacher R., Spraggon G., van den Bedem H., White A., Wolf G., Xu Q., Hodgson K.O., Wooley J., Deacon A.M., Godzik A., Lesley S.A., Wilson I.A.
    Proteins 68:418-424(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).
  7. "Crystal structure of the transcriptional regulator TM1030 with 24bp DNA oligonucleotide."
    Koclega K.D., Chruszcz M., Cooper D.R., Petkowski J.J., Tkaczuk K.L., Joachimiak A., Minor W.
    Submitted (NOV-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS).
  8. "Crystal structure of transcriptional regulator TM1030 with octanol."
    Koclega K.D., Chruszcz M., Cooper D.R., Petkowski J.J., Tkaczuk K.L., Joachimiak A., Minor W.
    Submitted (NOV-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MSB8Imported.

Entry informationi

Entry nameiQ9X0C0_THEMA
AccessioniPrimary (citable) accession number: Q9X0C0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3