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Q9X0C0

- Q9X0C0_THEMA

UniProt

Q9X0C0 - Q9X0C0_THEMA

Protein
Submitted name:

TetR family transcriptional regulator

Gene

TM_1030

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei85 – 851Hexaethylene glycolImported
    Binding sitei89 – 891Hexaethylene glycolImported

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciTMAR243274:GC6P-1059-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    TetR family transcriptional regulatorImported
    Submitted name:
    Transcriptional regulator, TetR familyImported
    Gene namesi
    Ordered Locus Names:TM_1030Imported
    ORF Names:THEMA_09210Imported
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Imported
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi243274.TM1030.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1Z77X-ray2.00A1-200[»]
    1ZKGX-ray2.30A/B1-200[»]
    2ID6X-ray1.75A1-200[»]
    2IEKX-ray1.83A1-200[»]
    3IH2X-ray2.30A1-200[»]
    3IH3X-ray2.35A1-200[»]
    3IH4X-ray2.30A1-200[»]
    4I6ZX-ray3.20A/B1-200[»]
    4I76X-ray2.10A/B1-200[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9X0C0.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni158 – 1614Hexaethylene glycol bindingImported

    Sequence similaritiesi

    Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation
    Contains HTH tetR-type DNA-binding domain.SAAS annotation

    Phylogenomic databases

    OMAiMERWIEK.
    OrthoDBiEOG6ZH2G9.

    Family and domain databases

    Gene3Di1.10.10.60. 2 hits.
    1.10.357.10. 1 hit.
    InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
    IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    [Graphical view]
    PfamiPF00440. TetR_N. 1 hit.
    [Graphical view]
    PRINTSiPR00455. HTHTETR.
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEiPS01081. HTH_TETR_1. 1 hit.
    PS50977. HTH_TETR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9X0C0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSKRDAILK AAVEVFGKKG YDRATTDEIA EKAGVAKGLI FHYFKNKEEL    50
    YYQAYMSVTE KLQKEFENFL MKNRNRDIFD FMERWIEKKL EYSASHPEEA 100
    DFLITLVSVD EGLRKRILLD LEKSQRVFFD FVREKLKDLD LAEDVTEEIA 150
    LKFLMWFFSG FEEVYLRTYQ GKPELLKRDM NTLVEEVKVM LRILKKGMTK 200
    Length:200
    Mass (Da):23,801
    Last modified:November 1, 1999 - v1
    Checksum:iCBF79565CB2D4273
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36107.1.
    CP007013 Genomic DNA. Translation: AHD19062.1.
    PIRiE72303.
    RefSeqiNP_228836.1. NC_000853.1.
    YP_008991874.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD36107; AAD36107; TM_1030.
    GeneIDi897092.
    KEGGitma:TM1030.
    tmi:THEMA_09210.
    PATRICi23936989. VBITheMar51294_1043.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36107.1 .
    CP007013 Genomic DNA. Translation: AHD19062.1 .
    PIRi E72303.
    RefSeqi NP_228836.1. NC_000853.1.
    YP_008991874.1. NC_023151.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1Z77 X-ray 2.00 A 1-200 [» ]
    1ZKG X-ray 2.30 A/B 1-200 [» ]
    2ID6 X-ray 1.75 A 1-200 [» ]
    2IEK X-ray 1.83 A 1-200 [» ]
    3IH2 X-ray 2.30 A 1-200 [» ]
    3IH3 X-ray 2.35 A 1-200 [» ]
    3IH4 X-ray 2.30 A 1-200 [» ]
    4I6Z X-ray 3.20 A/B 1-200 [» ]
    4I76 X-ray 2.10 A/B 1-200 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243274.TM1030.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD36107 ; AAD36107 ; TM_1030 .
    GeneIDi 897092.
    KEGGi tma:TM1030.
    tmi:THEMA_09210.
    PATRICi 23936989. VBITheMar51294_1043.

    Phylogenomic databases

    OMAi MERWIEK.
    OrthoDBi EOG6ZH2G9.

    Enzyme and pathway databases

    BioCyci TMAR243274:GC6P-1059-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9X0C0.

    Family and domain databases

    Gene3Di 1.10.10.60. 2 hits.
    1.10.357.10. 1 hit.
    InterProi IPR023772. DNA-bd_HTH_TetR-type_CS.
    IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    [Graphical view ]
    Pfami PF00440. TetR_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00455. HTHTETR.
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEi PS01081. HTH_TETR_1. 1 hit.
    PS50977. HTH_TETR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099Imported and MSB8Imported.
    2. "Crystal structure of transcriptional regulator (tm1030) at 1.75A resolution."
      Koclega K.D., Chruszcz M., Minor W.
      Submitted (SEP-2006) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS).
    3. "New crystal form of transcriptional regulator tm1030 from Thermotoga maritima."
      Koclega K.D., Chruszcz M., Minor W.
      Submitted (SEP-2006) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS).
    4. "Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment."
      Koclega K.D., Chruszcz M., Zimmerman M.D., Cymborowski M., Evdokimova E., Minor W.
      J. Struct. Biol. 159:424-432(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
    5. "Crystal structure of TM1030 from Thermotoga maritima at 2.3 A resolution reveals molecular details of its transcription repressor function."
      Premkumar L., Rife C.L., Sri Krishna S., McMullan D., Miller M.D., Abdubek P., Ambing E., Astakhova T., Axelrod H.L., Canaves J.M., Carlton D., Chiu H.J., Clayton T., DiDonato M., Duan L., Elsliger M.A., Feuerhelm J., Floyd R.
      , Grzechnik S.K., Hale J., Hampton E., Han G.W., Haugen J., Jaroszewski L., Jin K.K., Klock H.E., Knuth M.W., Koesema E., Kovarik J.S., Kreusch A., Levin I., McPhillips T.M., Morse A.T., Nigoghossian E., Okach L., Oommachen S., Paulsen J., Quijano K., Reyes R., Rezezadeh F., Rodionov D., Schwarzenbacher R., Spraggon G., van den Bedem H., White A., Wolf G., Xu Q., Hodgson K.O., Wooley J., Deacon A.M., Godzik A., Lesley S.A., Wilson I.A.
      Proteins 68:418-424(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).
    6. Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).
    7. "Crystal structure of the transcriptional regulator TM1030 with 24bp DNA oligonucleotide."
      Koclega K.D., Chruszcz M., Cooper D.R., Petkowski J.J., Tkaczuk K.L., Joachimiak A., Minor W.
      Submitted (NOV-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS).
    8. "Crystal structure of transcriptional regulator TM1030 with octanol."
      Koclega K.D., Chruszcz M., Cooper D.R., Petkowski J.J., Tkaczuk K.L., Joachimiak A., Minor W.
      Submitted (NOV-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MSB8Imported.

    Entry informationi

    Entry nameiQ9X0C0_THEMA
    AccessioniPrimary (citable) accession number: Q9X0C0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1999
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3