Q9X0C0 (Q9X0C0_THEMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Transcriptional regulator, TetR family EMBL AAD36107.1

Gene names

Ordered Locus Names:

TM_1030 EMBL AAD36107.1

Organism

Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [Reference proteome] [HAMAP] EMBL AAD36107.1

Taxonomic identifier

243274 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Thermotogae › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga › Thermotoga maritima

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 HTH tetR-type DNA-binding domain. RuleBase RU000710 SAAS SAAS011075

Ontologies

Keywords
Biological process	Transcription Transcription regulation RuleBase RU000710 SAAS SAAS011075
Ligand	DNA-binding RuleBase RU000710 SAAS SAAS011075
Molecular function	Repressor SAAS SAAS011075
Technical term	3D-structure PDB 4I6Z PDB 2IEK PDB 1ZKG PDB 2ID6 PDB 1Z77 PDB 3IH4 PDB 3IH3 PDB 3IH2 PDB 4I76 Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9X0C0 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: CBF79565CB2D4273	FASTA	200	23,801
	10 20 30 40 50 60 MLSKRDAILK AAVEVFGKKG YDRATTDEIA EKAGVAKGLI FHYFKNKEEL YYQAYMSVTE 70 80 90 100 110 120 KLQKEFENFL MKNRNRDIFD FMERWIEKKL EYSASHPEEA DFLITLVSVD EGLRKRILLD 130 140 150 160 170 180 LEKSQRVFFD FVREKLKDLD LAEDVTEEIA LKFLMWFFSG FEEVYLRTYQ GKPELLKRDM 190 200 NTLVEEVKVM LRILKKGMTK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D., Heidelberg J., Sutton G.G., Fleischmann R.D., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
[2]	"Crystal structure of transcriptional regulator (tm1030) at 1.75A resolution." Koclega K.D., Chruszcz M., Minor W. Submitted (SEP-2006) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS).
[3]	"New crystal form of transcriptional regulator tm1030 from Thermotoga maritima." Koclega K.D., Chruszcz M., Minor W. Submitted (SEP-2006) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS).
[4]	"Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment." Koclega K.D., Chruszcz M., Zimmerman M.D., Cymborowski M., Evdokimova E., Minor W. J. Struct. Biol. 159:424-432(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
[5]	"Crystal structure of TM1030 from Thermotoga maritima at 2.3 A resolution reveals molecular details of its transcription repressor function." Premkumar L., Rife C.L., Sri Krishna S., McMullan D., Miller M.D., Abdubek P., Ambing E., Astakhova T., Axelrod H.L., Canaves J.M., Carlton D., Chiu H.J., Clayton T., DiDonato M., Duan L., Elsliger M.A., Feuerhelm J., Floyd R. , Grzechnik S.K., Hale J., Hampton E., Han G.W., Haugen J., Jaroszewski L., Jin K.K., Klock H.E., Knuth M.W., Koesema E., Kovarik J.S., Kreusch A., Levin I., McPhillips T.M., Morse A.T., Nigoghossian E., Okach L., Oommachen S., Paulsen J., Quijano K., Reyes R., Rezezadeh F., Rodionov D., Schwarzenbacher R., Spraggon G., van den Bedem H., White A., Wolf G., Xu Q., Hodgson K.O., Wooley J., Deacon A.M., Godzik A., Lesley S.A., Wilson I.A. Proteins 68:418-424(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 2-200.
[6]	"'Hot' macromolecular crystals." Koclega K.D., Chruszcz M., Zimmerman M.D., Bujacz G., Minor W. Cryst. Growth Des. 10:580-580(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).
[7]	"Crystal structure of the transcriptional regulator TM1030 with 24bp DNA oligonucleotide." Koclega K.D., Chruszcz M., Cooper D.R., Petkowski J.J., Tkaczuk K.L., Joachimiak A., Minor W. Submitted (NOV-2012) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS).
[8]	"Crystal structure of transcriptional regulator TM1030 with octanol." Koclega K.D., Chruszcz M., Cooper D.R., Petkowski J.J., Tkaczuk K.L., Joachimiak A., Minor W. Submitted (NOV-2012) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000512 Genomic DNA. Translation: AAD36107.1.

PIR

E72303.

RefSeq

NP_228836.1. NC_000853.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1Z77	X-ray	2.00	A	1-200	[»]
1ZKG	X-ray	2.30	A/B	2-200	[»]
2ID6	X-ray	1.75	A	1-200	[»]
2IEK	X-ray	1.83	A	1-200	[»]
3IH2	X-ray	2.30	A	1-200	[»]
3IH3	X-ray	2.35	A	1-200	[»]
3IH4	X-ray	2.30	A	1-200	[»]
4I6Z	X-ray	3.20	A/B	1-200	[»]
4I76	X-ray	2.10	A/B	1-200	[»]

ProteinModelPortal

Q9X0C0.

SMR

Q9X0C0. Positions 1-200.

ModBase

Search...

Protein-protein interaction databases

STRING

243274.TM1030.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAD36107; AAD36107; TM_1030.

GeneID

897092.

KEGG

tma:TM1030.

PATRIC

23936989. VBITheMar51294_1043.

Phylogenomic databases

OMA

MERWIEK.

ProtClustDB

CLSK875529.

Enzyme and pathway databases

BioCyc

TMAR243274:GC6P-1059-MONOMER.

Family and domain databases

Gene3D

1.10.10.60. 2 hits.
1.10.357.10. 1 hit.

InterPro

IPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]

Pfam

PF00440. TetR_N. 1 hit.
[Graphical view]

PRINTS

PR00455. HTHTETR.

SUPFAM

SSF46689. Homeodomain_like. 1 hit.
SSF48498. TetR_like_C. 1 hit.

PROSITE

PS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9X0C0.

Entry information

Entry name

Q9X0C0_THEMA

Accession

Primary (citable) accession number: Q9X0C0

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	May 29, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)