Reviewed, UniProtKB/Swiss-Prot Q9X049 (GLPK1_THEMA)

Names and origin

Protein names

Recommended name:
    Glycerol kinase 1
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase 1
    Glycerokinase 1
      Short name=GK 1

Gene names

Name:	glpK1
Ordered Locus Names:	TM_0952

Organism

Thermotoga maritima [Complete proteome] [HAMAP]

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186
Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP glycerol kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 492	492	Glycerol kinase 1 HAMAP MF_00186		PRO_0000059513
Regions
	Nucleotide binding	407 – 411	5	ATP By similarity
Sites
	Binding site	10	1	Substrate By similarity
	Binding site	14	1	ATP By similarity
	Binding site	80	1	Substrate By similarity
	Binding site	132	1	Substrate By similarity
	Binding site	241	1	Substrate By similarity
	Binding site	263	1	ATP By similarity
	Binding site	306	1	ATP; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9X049-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 7D09C7849FB0221E	FASTA	492	55,091
	10 20 30 40 50 60 MYVLAIDQST SGTKAIIFDE KGGIVHRVTV YHKQYYPKPG WVEHDPEEIF RNTLDACRKV 70 80 90 100 110 120 IEESGIKPLE IEALAITNQR ETTILWEKKS GKPVYNAVVW QCQRGASLCE EIKKRGLEGK 130 140 150 160 170 180 IKEKTGLVVD PYFSASKIRW ILDNVEGVKN KAKQGEIAFG TVDSWLIWKL TKGEVHATDF 190 200 210 220 230 240 SNASRTLLLN IHELRWDEEV LEIFEIPPEI LPELKSSDSV FGYTDLGFLP KKIPIVGVMG 250 260 270 280 290 300 DSSAALFGQG GFYSGDIKVT YGTGSSTMLN IGEKPNVSDS PIVCSVGWVV KETSSYVLEG 310 320 330 340 350 360 NIHSAGDTIV WLKEKLGIIS DPSETEKIAL SLENNGGVYL VPAFVGLGAP YWRSDVKAAI 370 380 390 400 410 420 LGLQRNHGKE HVVRAALESI AYQVRDIFEE MVRISSKEPT EVRADGGITR NRFLMQFQAD 430 440 450 460 470 480 ILNIPVLVSN IEEVSARGVA FVALLHLGAF SDLEEIRQKI TYREKYEPRM GDELREMYYE 490 GWKTAIRKLL TE

References

[1]

"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000512 Genomic DNA. Translation: AAD36033.1.
PIR	C72314.
RefSeq	NP_228760.1.
3D structure databases
HSSP	HSSP built from PDB template 1GLJ based on UniProtKB P08859.
ModBase	Search...
Genome annotation databases
GeneID	898689.
GenomeReviews	Gene locus TM_0952 in contig AE000512_GR.
KEGG	tma:TM0952.
NMPDR	fig|243274.1.peg.944.
TIGR	TM_0952.
Phylogenomic databases
HOGENOM	Q9X049.
OMA	AIDQSTS.
Enzyme and pathway databases
BioCyc	TMAR243274:TM_0952-MON.
BRENDA	2.7.1.30. 16699.
Family and domain databases
HAMAP	MF_00186. [Tree]
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01311. glycerol_kin. 1 hit.
PROSITE	PS00933. FGGY_KINASES_1. 1 hit. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK1_THEMA

Accession

Primary (citable) accession number: Q9X049

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	November 3, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)