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Q9X027

- TRMB_THEMA

UniProt

Q9X027 - TRMB_THEMA

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331S-adenosyl-L-methionineUniRule annotation
    Binding sitei58 – 581S-adenosyl-L-methionineUniRule annotation
    Binding sitei85 – 851S-adenosyl-L-methionineUniRule annotation
    Binding sitei112 – 1121SubstrateUniRule annotation
    Binding sitei144 – 1441SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:TM_0925
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313tRNA (guanine-N(7)-)-methyltransferasePRO_0000171413Add
    BLAST

    Proteomic databases

    PRIDEiQ9X027.

    Interactioni

    Protein-protein interaction databases

    STRINGi243274.TM0925.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9X027.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni177 – 1804Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    KOiK03439.
    OMAiFPCPWPK.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9X027-1 [UniParc]FASTAAdd to Basket

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    MVVTEYELKP QNFPRFPLDW SEIFGRKAKI VVEIGFGNGE FLAELARRHP    50
    EKDFVGFEVS ITSFVKAQKK FKRYNLKNVR LVKVDARFGL RELFPDNSVE 100
    KVYINFPCPW PKKRHESRRI TSYDFLQTLS AVLEMDGTVE FATDEEWYAR 150
    EVLDTFESSE YFVVDVFEEN FKRDVETRYE RKWKSQGKKT FLIVARKVKN 200
    GTVKRLMEGE NTMAHSVFEG NVTWEKLKEL EGKVFKDKNK IFVVKKVYRD 250
    GDYLLKVIST DEGGFQQVYY LNLSGRDGKW VLKLDEGSDP YRTPALKWSL 300
    RRIPEELTAQ GSP 313
    Length:313
    Mass (Da):36,770
    Last modified:November 1, 1999 - v1
    Checksum:i34EE4D3669AD2CF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36006.1.
    PIRiF72317.
    RefSeqiNP_228733.1. NC_000853.1.
    YP_007977277.1. NC_021214.1.
    YP_008990105.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD36006; AAD36006; TM_0925.
    GeneIDi898599.
    KEGGitma:TM0925.
    tmi:THEMA_00010.
    tmm:Tmari_0927.
    PATRICi23936781. VBITheMar51294_0939.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD36006.1 .
    PIRi F72317.
    RefSeqi NP_228733.1. NC_000853.1.
    YP_007977277.1. NC_021214.1.
    YP_008990105.1. NC_023151.1.

    3D structure databases

    ProteinModelPortali Q9X027.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243274.TM0925.

    Proteomic databases

    PRIDEi Q9X027.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD36006 ; AAD36006 ; TM_0925 .
    GeneIDi 898599.
    KEGGi tma:TM0925.
    tmi:THEMA_00010.
    tmm:Tmari_0927.
    PATRICi 23936781. VBITheMar51294_0939.

    Phylogenomic databases

    eggNOGi COG0220.
    KOi K03439.
    OMAi FPCPWPK.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

    Entry informationi

    Entry nameiTRMB_THEMA
    AccessioniPrimary (citable) accession number: Q9X027
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3