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Q9X017 (RNH2_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease HII

Short name=RNase HII
EC=3.1.26.4
Gene names
Name:rnhB
Ordered Locus Names:TM_0915
OrganismThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [Reference proteome] [HAMAP]
Taxonomic identifier243274 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids By similarity. HAMAP-Rule MF_00052_B

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00052_B

Cofactor

Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding By similarity.

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00052_B.

Sequence similarities

Belongs to the RNase HII family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandManganese
Metal-binding
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRNA catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: InterPro

RNA-DNA hybrid ribonuclease activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

manganese ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 238238Ribonuclease HII HAMAP-Rule MF_00052_B
PRO_0000111643

Sites

Metal binding181Divalent metal cation By similarity
Metal binding191Divalent metal cation By similarity
Metal binding1071Divalent metal cation By similarity

Secondary structure

........................................ 238
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9X017 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 2A0C0156954AE923

FASTA23826,630
        10         20         30         40         50         60 
MGIDELYKKE FGIVAGVDEA GRGCLAGPVV AAAVVLEKEI EGINDSKQLS PAKRERLLDE 

        70         80         90        100        110        120 
IMEKAAVGIG IASPEEIDLY NIFNATKLAM NRALENLSVK PSFVLVDGKG IELSVPGTCL 

       130        140        150        160        170        180 
VKGDQKSKLI GAASIVAKVF RDRLMSEFHR MYPQFSFHKH KGYATKEHLN EIRKNGVLPI 

       190        200        210        220        230 
HRLSFEPVLE LLTDDLLREF FEKGLISENR FERILNLLGA RKSVVFRKER TNHNLPLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000512 Genomic DNA. Translation: AAD35996.1.
PIRB72320.
RefSeqNP_228723.1. NC_000853.1.
YP_007977267.1. NC_021214.1.
YP_008990115.1. NC_023151.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2ETJX-ray1.74A1-238[»]
3O3FX-ray2.00A2-223[»]
3O3GX-ray2.10A2-223[»]
3O3HX-ray2.80A2-223[»]
4HHTX-ray3.10A2-238[»]
ProteinModelPortalQ9X017.
SMRQ9X017. Positions 1-221.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243274.TM0915.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD35996; AAD35996; TM_0915.
GeneID898589.
KEGGtma:TM0915.
tmi:THEMA_00060.
tmm:Tmari_0917.
PATRIC23936761. VBITheMar51294_0929.

Phylogenomic databases

eggNOGCOG0164.
KOK03470.
OMAAWCIARA.
OrthoDBEOG6BKJC8.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
HAMAPMF_00052_B. RNase_HII_B.
InterProIPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERPTHR10954. PTHR10954. 1 hit.
PfamPF01351. RNase_HII. 1 hit.
[Graphical view]
SUPFAMSSF53098. SSF53098. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ9X017.

Entry information

Entry nameRNH2_THEMA
AccessionPrimary (citable) accession number: Q9X017
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references