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Q9X017

- RNH2_THEMA

UniProt

Q9X017 - RNH2_THEMA

Protein

Ribonuclease HII

Gene

rnhB

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.By similarity

    Catalytic activityi

    Endonucleolytic cleavage to 5'-phosphomonoester.

    Cofactori

    Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi18 – 181Divalent metal cationBy similarity
    Metal bindingi19 – 191Divalent metal cationBy similarity
    Metal bindingi107 – 1071Divalent metal cationBy similarity

    GO - Molecular functioni

    1. manganese ion binding Source: UniProtKB-HAMAP
    2. RNA binding Source: InterPro
    3. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. RNA catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease HII (EC:3.1.26.4)
    Short name:
    RNase HII
    Gene namesi
    Name:rnhB
    Ordered Locus Names:TM_0915
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 238238Ribonuclease HIIPRO_0000111643Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243274.TM0915.

    Structurei

    Secondary structure

    1
    238
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 75
    Turni8 – 103
    Beta strandi11 – 2010
    Beta strandi25 – 273
    Beta strandi29 – 368
    Turni41 – 444
    Helixi46 – 483
    Helixi53 – 6412
    Beta strandi65 – 728
    Helixi74 – 807
    Helixi82 – 9615
    Beta strandi97 – 993
    Beta strandi102 – 1109
    Beta strandi117 – 1204
    Helixi123 – 1264
    Helixi128 – 15124
    Helixi157 – 1604
    Helixi166 – 17510
    Helixi186 – 1894
    Helixi194 – 2029
    Helixi208 – 21912
    Turni220 – 2223

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ETJX-ray1.74A1-238[»]
    3O3FX-ray2.00A2-223[»]
    3O3GX-ray2.10A2-223[»]
    3O3HX-ray2.80A2-223[»]
    4HHTX-ray3.10A2-238[»]
    ProteinModelPortaliQ9X017.
    SMRiQ9X017. Positions 1-221.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9X017.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RNase HII family.Curated

    Phylogenomic databases

    eggNOGiCOG0164.
    KOiK03470.
    OMAiAWCIARA.
    OrthoDBiEOG6BKJC8.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    HAMAPiMF_00052_B. RNase_HII_B.
    InterProiIPR022898. RNase_HII.
    IPR001352. RNase_HII/HIII.
    IPR024567. RNase_HII/HIII_dom.
    IPR012337. RNaseH-like_dom.
    [Graphical view]
    PANTHERiPTHR10954. PTHR10954. 1 hit.
    PfamiPF01351. RNase_HII. 1 hit.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9X017-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGIDELYKKE FGIVAGVDEA GRGCLAGPVV AAAVVLEKEI EGINDSKQLS    50
    PAKRERLLDE IMEKAAVGIG IASPEEIDLY NIFNATKLAM NRALENLSVK 100
    PSFVLVDGKG IELSVPGTCL VKGDQKSKLI GAASIVAKVF RDRLMSEFHR 150
    MYPQFSFHKH KGYATKEHLN EIRKNGVLPI HRLSFEPVLE LLTDDLLREF 200
    FEKGLISENR FERILNLLGA RKSVVFRKER TNHNLPLF 238
    Length:238
    Mass (Da):26,630
    Last modified:November 1, 1999 - v1
    Checksum:i2A0C0156954AE923
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD35996.1.
    PIRiB72320.
    RefSeqiNP_228723.1. NC_000853.1.
    YP_007977267.1. NC_021214.1.
    YP_008990115.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD35996; AAD35996; TM_0915.
    GeneIDi898589.
    KEGGitma:TM0915.
    tmi:THEMA_00060.
    tmm:Tmari_0917.
    PATRICi23936761. VBITheMar51294_0929.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD35996.1 .
    PIRi B72320.
    RefSeqi NP_228723.1. NC_000853.1.
    YP_007977267.1. NC_021214.1.
    YP_008990115.1. NC_023151.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ETJ X-ray 1.74 A 1-238 [» ]
    3O3F X-ray 2.00 A 2-223 [» ]
    3O3G X-ray 2.10 A 2-223 [» ]
    3O3H X-ray 2.80 A 2-223 [» ]
    4HHT X-ray 3.10 A 2-238 [» ]
    ProteinModelPortali Q9X017.
    SMRi Q9X017. Positions 1-221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243274.TM0915.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD35996 ; AAD35996 ; TM_0915 .
    GeneIDi 898589.
    KEGGi tma:TM0915.
    tmi:THEMA_00060.
    tmm:Tmari_0917.
    PATRICi 23936761. VBITheMar51294_0929.

    Phylogenomic databases

    eggNOGi COG0164.
    KOi K03470.
    OMAi AWCIARA.
    OrthoDBi EOG6BKJC8.

    Miscellaneous databases

    EvolutionaryTracei Q9X017.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    HAMAPi MF_00052_B. RNase_HII_B.
    InterProi IPR022898. RNase_HII.
    IPR001352. RNase_HII/HIII.
    IPR024567. RNase_HII/HIII_dom.
    IPR012337. RNaseH-like_dom.
    [Graphical view ]
    PANTHERi PTHR10954. PTHR10954. 1 hit.
    Pfami PF01351. RNase_HII. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53098. SSF53098. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

    Entry informationi

    Entry nameiRNH2_THEMA
    AccessioniPrimary (citable) accession number: Q9X017
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3