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Q9X017

- RNH2_THEMA

UniProt

Q9X017 - RNH2_THEMA

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Protein

Ribonuclease HII

Gene

rnhB

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.By similarity

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.

Cofactori

Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi18 – 181Divalent metal cationBy similarity
Metal bindingi19 – 191Divalent metal cationBy similarity
Metal bindingi107 – 1071Divalent metal cationBy similarity

GO - Molecular functioni

  1. manganese ion binding Source: UniProtKB-HAMAP
  2. RNA binding Source: InterPro
  3. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HII (EC:3.1.26.4)
Short name:
RNase HII
Gene namesi
Name:rnhB
Ordered Locus Names:TM_0915
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Ribonuclease HIIPRO_0000111643Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0915.

Structurei

Secondary structure

1
238
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 75
Turni8 – 103
Beta strandi11 – 2010
Beta strandi25 – 273
Beta strandi29 – 368
Turni41 – 444
Helixi46 – 483
Helixi53 – 6412
Beta strandi65 – 728
Helixi74 – 807
Helixi82 – 9615
Beta strandi97 – 993
Beta strandi102 – 1109
Beta strandi117 – 1204
Helixi123 – 1264
Helixi128 – 15124
Helixi157 – 1604
Helixi166 – 17510
Helixi186 – 1894
Helixi194 – 2029
Helixi208 – 21912
Turni220 – 2223

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ETJX-ray1.74A1-238[»]
3O3FX-ray2.00A2-223[»]
3O3GX-ray2.10A2-223[»]
3O3HX-ray2.80A2-223[»]
4HHTX-ray3.10A2-238[»]
ProteinModelPortaliQ9X017.
SMRiQ9X017. Positions 1-221.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X017.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family.Curated

Phylogenomic databases

eggNOGiCOG0164.
InParanoidiQ9X017.
KOiK03470.
OMAiAWCIARA.
OrthoDBiEOG6BKJC8.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00052_B. RNase_HII_B.
InterProiIPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10954. PTHR10954. 1 hit.
PfamiPF01351. RNase_HII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X017-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGIDELYKKE FGIVAGVDEA GRGCLAGPVV AAAVVLEKEI EGINDSKQLS
60 70 80 90 100
PAKRERLLDE IMEKAAVGIG IASPEEIDLY NIFNATKLAM NRALENLSVK
110 120 130 140 150
PSFVLVDGKG IELSVPGTCL VKGDQKSKLI GAASIVAKVF RDRLMSEFHR
160 170 180 190 200
MYPQFSFHKH KGYATKEHLN EIRKNGVLPI HRLSFEPVLE LLTDDLLREF
210 220 230
FEKGLISENR FERILNLLGA RKSVVFRKER TNHNLPLF
Length:238
Mass (Da):26,630
Last modified:November 1, 1999 - v1
Checksum:i2A0C0156954AE923
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD35996.1.
PIRiB72320.
RefSeqiNP_228723.1. NC_000853.1.
YP_007977267.1. NC_021214.1.
YP_008990115.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD35996; AAD35996; TM_0915.
GeneIDi18091868.
898589.
KEGGitma:TM0915.
tmi:THEMA_00060.
tmm:Tmari_0917.
PATRICi23936761. VBITheMar51294_0929.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD35996.1 .
PIRi B72320.
RefSeqi NP_228723.1. NC_000853.1.
YP_007977267.1. NC_021214.1.
YP_008990115.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ETJ X-ray 1.74 A 1-238 [» ]
3O3F X-ray 2.00 A 2-223 [» ]
3O3G X-ray 2.10 A 2-223 [» ]
3O3H X-ray 2.80 A 2-223 [» ]
4HHT X-ray 3.10 A 2-238 [» ]
ProteinModelPortali Q9X017.
SMRi Q9X017. Positions 1-221.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM0915.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD35996 ; AAD35996 ; TM_0915 .
GeneIDi 18091868.
898589.
KEGGi tma:TM0915.
tmi:THEMA_00060.
tmm:Tmari_0917.
PATRICi 23936761. VBITheMar51294_0929.

Phylogenomic databases

eggNOGi COG0164.
InParanoidi Q9X017.
KOi K03470.
OMAi AWCIARA.
OrthoDBi EOG6BKJC8.

Miscellaneous databases

EvolutionaryTracei Q9X017.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00052_B. RNase_HII_B.
InterProi IPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view ]
PANTHERi PTHR10954. PTHR10954. 1 hit.
Pfami PF01351. RNase_HII. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiRNH2_THEMA
AccessioniPrimary (citable) accession number: Q9X017
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3