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Protein

Methylthioribose-1-phosphate isomerase

Gene

mtnA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).UniRule annotation

Catalytic activityi

S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.UniRule annotation

Pathwayi: L-methionine biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Methylthioribose-1-phosphate isomerase (mtnA), Methylthioribose-1-phosphate isomerase (mtnA)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway L-methionine biosynthesis via salvage pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate, the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei88Substrate1
Sitei154Transition state stabilizerUniRule annotation1
Binding sitei193SubstrateUniRule annotation1
Active sitei234Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00904; UER00874.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylthioribose-1-phosphate isomeraseUniRule annotation (EC:5.3.1.23UniRule annotation)
Short name:
M1PiUniRule annotation
Short name:
MTR-1-P isomeraseUniRule annotation
Alternative name(s):
S-methyl-5-thioribose-1-phosphate isomeraseUniRule annotation
Gene namesi
Name:mtnAUniRule annotation
Ordered Locus Names:TM_0911
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001560941 – 343Methylthioribose-1-phosphate isomeraseAdd BLAST343

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0911.

Structurei

Secondary structure

1343
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 10Combined sources5
Beta strandi15 – 18Combined sources4
Turni20 – 25Combined sources6
Beta strandi29 – 32Combined sources4
Helixi35 – 43Combined sources9
Helixi50 – 66Combined sources17
Helixi73 – 85Combined sources13
Helixi93 – 106Combined sources14
Turni107 – 110Combined sources4
Helixi114 – 141Combined sources28
Beta strandi148 – 152Combined sources5
Helixi158 – 160Combined sources3
Beta strandi161 – 164Combined sources4
Helixi167 – 176Combined sources10
Beta strandi181 – 186Combined sources6
Turni189 – 192Combined sources4
Helixi193 – 196Combined sources4
Helixi198 – 203Combined sources6
Turni204 – 206Combined sources3
Beta strandi208 – 212Combined sources5
Helixi214 – 216Combined sources3
Helixi217 – 222Combined sources6
Beta strandi227 – 231Combined sources5
Beta strandi234 – 237Combined sources4
Beta strandi242 – 245Combined sources4
Helixi248 – 257Combined sources10
Beta strandi262 – 265Combined sources4
Helixi268 – 270Combined sources3
Helixi278 – 280Combined sources3
Helixi289 – 292Combined sources4
Beta strandi309 – 314Combined sources6
Helixi316 – 318Combined sources3
Beta strandi320 – 324Combined sources5
Beta strandi327 – 329Combined sources3
Helixi333 – 341Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T9KX-ray2.60A/B/C/D1-343[»]
ProteinModelPortaliQ9X013.
SMRiQ9X013.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X013.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni48 – 50Substrate binding3
Regioni244 – 245Substrate binding2

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C35. Bacteria.
COG0182. LUCA.
InParanoidiQ9X013.
KOiK08963.
OMAiFYNPAFD.

Family and domain databases

Gene3Di1.20.120.420. 1 hit.
HAMAPiMF_01678. Salvage_MtnA. 1 hit.
InterProiIPR000649. IF-2B-related.
IPR005251. IF-M1Pi.
IPR011559. Initiation_fac_2B_a/b/d.
IPR027363. M1Pi_N.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00524. eIF-2B_rel. 1 hit.
TIGR00512. salvage_mtnA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLKTKTMEW SGNSLKLLDQ RKLPFIEEYV ECKTHEEVAH AIKEMIVRGA
60 70 80 90 100
PAIGVAAAFG YVLGLRDYKT GSLTDWMKQV KETLARTRPT AVNLFWALNR
110 120 130 140 150
MEKVFFENAD RENLFEILEN EALKMAYEDI EVNKAIGKNG AQLIKDGSTI
160 170 180 190 200
LTHCNAGALA TVDYGTALGV IRAAVESGKR IRVFADETRP YLQGARLTAW
210 220 230 240 250
ELMKDGIEVY VITDNMAGWL MKRGLIDAVV VGADRIALNG DTANKIGTYS
260 270 280 290 300
LAVLAKRNNI PFYVAAPVST IDPTIRSGEE IPIEERRPEE VTHCGGNRIA
310 320 330 340
PEGVKVLNPA FDVTENTLIT AIITEKGVIR PPFEENIKKI LEV
Length:343
Mass (Da):38,050
Last modified:November 1, 1999 - v1
Checksum:i462EB159438C5BEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35992.1.
PIRiF72319.
RefSeqiNP_228719.1. NC_000853.1.
WP_004080652.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD35992; AAD35992; TM_0911.
GeneIDi898585.
KEGGitma:TM0911.
PATRICi23936753. VBITheMar51294_0925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35992.1.
PIRiF72319.
RefSeqiNP_228719.1. NC_000853.1.
WP_004080652.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T9KX-ray2.60A/B/C/D1-343[»]
ProteinModelPortaliQ9X013.
SMRiQ9X013.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0911.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35992; AAD35992; TM_0911.
GeneIDi898585.
KEGGitma:TM0911.
PATRICi23936753. VBITheMar51294_0925.

Phylogenomic databases

eggNOGiENOG4105C35. Bacteria.
COG0182. LUCA.
InParanoidiQ9X013.
KOiK08963.
OMAiFYNPAFD.

Enzyme and pathway databases

UniPathwayiUPA00904; UER00874.

Miscellaneous databases

EvolutionaryTraceiQ9X013.

Family and domain databases

Gene3Di1.20.120.420. 1 hit.
HAMAPiMF_01678. Salvage_MtnA. 1 hit.
InterProiIPR000649. IF-2B-related.
IPR005251. IF-M1Pi.
IPR011559. Initiation_fac_2B_a/b/d.
IPR027363. M1Pi_N.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00524. eIF-2B_rel. 1 hit.
TIGR00512. salvage_mtnA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTNA_THEMA
AccessioniPrimary (citable) accession number: Q9X013
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.