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Protein

Methylthioribose-1-phosphate isomerase

Gene

mtnA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).UniRule annotation

Catalytic activityi

S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.UniRule annotation

Pathwayi: L-methionine biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Methylthioribose-1-phosphate isomerase (mtnA), Methylthioribose-1-phosphate isomerase (mtnA)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway L-methionine biosynthesis via salvage pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate, the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881Substrate
Sitei154 – 1541Transition state stabilizerUniRule annotation
Binding sitei193 – 1931SubstrateUniRule annotation
Active sitei234 – 2341Proton donorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00904; UER00874.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylthioribose-1-phosphate isomeraseUniRule annotation (EC:5.3.1.23UniRule annotation)
Short name:
M1PiUniRule annotation
Short name:
MTR-1-P isomeraseUniRule annotation
Alternative name(s):
S-methyl-5-thioribose-1-phosphate isomeraseUniRule annotation
Gene namesi
Name:mtnAUniRule annotation
Ordered Locus Names:TM_0911
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Methylthioribose-1-phosphate isomerasePRO_0000156094Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0911.

Structurei

Secondary structure

1
343
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 105Combined sources
Beta strandi15 – 184Combined sources
Turni20 – 256Combined sources
Beta strandi29 – 324Combined sources
Helixi35 – 439Combined sources
Helixi50 – 6617Combined sources
Helixi73 – 8513Combined sources
Helixi93 – 10614Combined sources
Turni107 – 1104Combined sources
Helixi114 – 14128Combined sources
Beta strandi148 – 1525Combined sources
Helixi158 – 1603Combined sources
Beta strandi161 – 1644Combined sources
Helixi167 – 17610Combined sources
Beta strandi181 – 1866Combined sources
Turni189 – 1924Combined sources
Helixi193 – 1964Combined sources
Helixi198 – 2036Combined sources
Turni204 – 2063Combined sources
Beta strandi208 – 2125Combined sources
Helixi214 – 2163Combined sources
Helixi217 – 2226Combined sources
Beta strandi227 – 2315Combined sources
Beta strandi234 – 2374Combined sources
Beta strandi242 – 2454Combined sources
Helixi248 – 25710Combined sources
Beta strandi262 – 2654Combined sources
Helixi268 – 2703Combined sources
Helixi278 – 2803Combined sources
Helixi289 – 2924Combined sources
Beta strandi309 – 3146Combined sources
Helixi316 – 3183Combined sources
Beta strandi320 – 3245Combined sources
Beta strandi327 – 3293Combined sources
Helixi333 – 3419Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1T9KX-ray2.60A/B/C/D1-343[»]
ProteinModelPortaliQ9X013.
SMRiQ9X013. Positions 1-342.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X013.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni48 – 503Substrate binding
Regioni244 – 2452Substrate binding

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C35. Bacteria.
COG0182. LUCA.
InParanoidiQ9X013.
KOiK08963.
OMAiFYNPAFD.

Family and domain databases

Gene3Di1.20.120.420. 1 hit.
HAMAPiMF_01678. Salvage_MtnA. 1 hit.
InterProiIPR000649. IF-2B-related.
IPR005251. IF-M1Pi.
IPR011559. Initiation_fac_2B_a/b/d.
IPR027363. M1Pi_N.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00524. eIF-2B_rel. 1 hit.
TIGR00512. salvage_mtnA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLKTKTMEW SGNSLKLLDQ RKLPFIEEYV ECKTHEEVAH AIKEMIVRGA
60 70 80 90 100
PAIGVAAAFG YVLGLRDYKT GSLTDWMKQV KETLARTRPT AVNLFWALNR
110 120 130 140 150
MEKVFFENAD RENLFEILEN EALKMAYEDI EVNKAIGKNG AQLIKDGSTI
160 170 180 190 200
LTHCNAGALA TVDYGTALGV IRAAVESGKR IRVFADETRP YLQGARLTAW
210 220 230 240 250
ELMKDGIEVY VITDNMAGWL MKRGLIDAVV VGADRIALNG DTANKIGTYS
260 270 280 290 300
LAVLAKRNNI PFYVAAPVST IDPTIRSGEE IPIEERRPEE VTHCGGNRIA
310 320 330 340
PEGVKVLNPA FDVTENTLIT AIITEKGVIR PPFEENIKKI LEV
Length:343
Mass (Da):38,050
Last modified:November 1, 1999 - v1
Checksum:i462EB159438C5BEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35992.1.
PIRiF72319.
RefSeqiNP_228719.1. NC_000853.1.
WP_004080652.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD35992; AAD35992; TM_0911.
GeneIDi898585.
KEGGitma:TM0911.
tmi:THEMA_00080.
tmw:THMA_0933.
PATRICi23936753. VBITheMar51294_0925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35992.1.
PIRiF72319.
RefSeqiNP_228719.1. NC_000853.1.
WP_004080652.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1T9KX-ray2.60A/B/C/D1-343[»]
ProteinModelPortaliQ9X013.
SMRiQ9X013. Positions 1-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0911.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35992; AAD35992; TM_0911.
GeneIDi898585.
KEGGitma:TM0911.
tmi:THEMA_00080.
tmw:THMA_0933.
PATRICi23936753. VBITheMar51294_0925.

Phylogenomic databases

eggNOGiENOG4105C35. Bacteria.
COG0182. LUCA.
InParanoidiQ9X013.
KOiK08963.
OMAiFYNPAFD.

Enzyme and pathway databases

UniPathwayiUPA00904; UER00874.

Miscellaneous databases

EvolutionaryTraceiQ9X013.

Family and domain databases

Gene3Di1.20.120.420. 1 hit.
HAMAPiMF_01678. Salvage_MtnA. 1 hit.
InterProiIPR000649. IF-2B-related.
IPR005251. IF-M1Pi.
IPR011559. Initiation_fac_2B_a/b/d.
IPR027363. M1Pi_N.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00524. eIF-2B_rel. 1 hit.
TIGR00512. salvage_mtnA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTNA_THEMA
AccessioniPrimary (citable) accession number: Q9X013
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.