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Q9WZZ5 (UPPP_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:TM_0893
OrganismThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [Reference proteome] [HAMAP]
Taxonomic identifier243274 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Protein attributes

Sequence length237 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 237237Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151227

Regions

Transmembrane38 – 5821Helical; Potential
Transmembrane65 – 8521Helical; Potential
Transmembrane92 – 11221Helical; Potential
Transmembrane126 – 14621Helical; Potential
Transmembrane166 – 18621Helical; Potential
Transmembrane191 – 21121Helical; Potential
Transmembrane217 – 23721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9WZZ5 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 759239335C5FE10F

FASTA23726,036
        10         20         30         40         50         60 
MDLLLGIVQG LTEFLPISSS GHLTLLSHLL KTDLNAYQTA VLHLGTLVSV VLFALDGIRR 

        70         80         90        100        110        120 
SLRSWRIILN LIVSTIPAGV FGVLFEKQID QLFSSPRFLP LFFSATALIL MFTRYSSSGE 

       130        140        150        160        170        180 
KRMENMSFLD ALLVGIAQLF ALFPGISRSG ITVSSLLFMK YRSEDALQYS FLMSIPVVLG 

       190        200        210        220        230 
AGILGLGKGN VTILAPIFAF LSGLFALYVL SRSVRSGKIW QFSYYCLFVA ILSYLAG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000512 Genomic DNA. Translation: AAD35974.1.
PIRF72321.
RefSeqNP_228701.1. NC_000853.1.
YP_007977245.1. NC_021214.1.
YP_008990137.1. NC_023151.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243274.TM0893.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD35974; AAD35974; TM_0893.
GeneID15494498.
18091890.
898567.
KEGGtma:TM0893.
tmm:Tmari_0895.
PATRIC23936717. VBITheMar51294_0907.

Phylogenomic databases

eggNOGCOG1968.
KOK06153.
OMASKTQIMF.
OrthoDBEOG6QP13M.
ProtClustDBCLSK795538.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_THEMA
AccessionPrimary (citable) accession number: Q9WZZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: November 1, 1999
Last modified: March 19, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families