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Q9WZZ5

- UPPP_THEMA

UniProt

Q9WZZ5 - UPPP_THEMA

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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Synonyms:bacA, upk
Ordered Locus Names:TM_0893
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5821HelicalUniRule annotationAdd
BLAST
Transmembranei65 – 8521HelicalUniRule annotationAdd
BLAST
Transmembranei92 – 11221HelicalUniRule annotationAdd
BLAST
Transmembranei126 – 14621HelicalUniRule annotationAdd
BLAST
Transmembranei166 – 18621HelicalUniRule annotationAdd
BLAST
Transmembranei191 – 21121HelicalUniRule annotationAdd
BLAST
Transmembranei217 – 23721HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Undecaprenyl-diphosphatasePRO_0000151227Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0893.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
InParanoidiQ9WZZ5.
KOiK06153.
OMAiNANEAVD.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WZZ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLLLGIVQG LTEFLPISSS GHLTLLSHLL KTDLNAYQTA VLHLGTLVSV
60 70 80 90 100
VLFALDGIRR SLRSWRIILN LIVSTIPAGV FGVLFEKQID QLFSSPRFLP
110 120 130 140 150
LFFSATALIL MFTRYSSSGE KRMENMSFLD ALLVGIAQLF ALFPGISRSG
160 170 180 190 200
ITVSSLLFMK YRSEDALQYS FLMSIPVVLG AGILGLGKGN VTILAPIFAF
210 220 230
LSGLFALYVL SRSVRSGKIW QFSYYCLFVA ILSYLAG
Length:237
Mass (Da):26,036
Last modified:November 1, 1999 - v1
Checksum:i759239335C5FE10F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35974.1.
PIRiF72321.
RefSeqiNP_228701.1. NC_000853.1.
YP_007977245.1. NC_021214.1.
YP_008990137.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD35974; AAD35974; TM_0893.
GeneIDi18091890.
898567.
KEGGitma:TM0893.
PATRICi23936717. VBITheMar51294_0907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35974.1 .
PIRi F72321.
RefSeqi NP_228701.1. NC_000853.1.
YP_007977245.1. NC_021214.1.
YP_008990137.1. NC_023151.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM0893.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD35974 ; AAD35974 ; TM_0893 .
GeneIDi 18091890.
898567.
KEGGi tma:TM0893.
PATRICi 23936717. VBITheMar51294_0907.

Phylogenomic databases

eggNOGi COG1968.
InParanoidi Q9WZZ5.
KOi K06153.
OMAi NANEAVD.
OrthoDBi EOG6QP13M.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiUPPP_THEMA
AccessioniPrimary (citable) accession number: Q9WZZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3