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Protein

Type III pantothenate kinase

Gene

coaX

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.1 Publication

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.

Cofactori

NH4(+)By similarity, K+By similarityNote: A monovalent cation. Ammonium or potassium.By similarity

Kineticsi

  1. KM=40 µM for pantothenate (at 50 degrees Celsius)1 Publication
  2. KM=6.0 mM for ATP (at 50 degrees Celsius)1 Publication

    Pathwayi: coenzyme A biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.
    Proteins known to be involved in the 5 steps of the subpathway in this organism are:
    1. Type III pantothenate kinase (coaX), Type III pantothenate kinase (coaX)
    2. no protein annotated in this organism
    3. no protein annotated in this organism
    4. Phosphopantetheine adenylyltransferase (coaD), Phosphopantetheine adenylyltransferase (coaD)
    5. Dephospho-CoA kinase (coaE), Dephospho-CoA kinase (coaE)
    This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Active sitei105Proton acceptorSequence analysis1
    Metal bindingi125Monovalent cationSequence analysis1
    Binding sitei128ATPSequence analysis1
    Binding sitei179SubstrateBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi6 – 13ATPBy similarity8

    GO - Molecular functioni

    GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Coenzyme A biosynthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Potassium

    Enzyme and pathway databases

    BRENDAi2.7.1.33. 6331.
    SABIO-RKQ9WZY5.
    UniPathwayiUPA00241; UER00352.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type III pantothenate kinase (EC:2.7.1.33)
    Alternative name(s):
    PanK-III
    Pantothenic acid kinase
    Gene namesi
    Name:coaX
    Ordered Locus Names:TM_0883
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    Proteomesi
    • UP000008183 Componenti: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002675981 – 246Type III pantothenate kinaseAdd BLAST246

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    STRINGi243274.TM0883.

    Structurei

    Secondary structure

    1246
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Beta strandi1 – 7Combined sources7
    Beta strandi9 – 22Combined sources14
    Beta strandi24 – 29Combined sources6
    Helixi36 – 47Combined sources12
    Helixi48 – 53Combined sources6
    Beta strandi54 – 62Combined sources9
    Helixi64 – 78Combined sources15
    Beta strandi89 – 94Combined sources6
    Helixi99 – 101Combined sources3
    Helixi104 – 116Combined sources13
    Beta strandi121 – 136Combined sources16
    Beta strandi139 – 147Combined sources9
    Helixi149 – 158Combined sources10
    Beta strandi173 – 178Combined sources6
    Helixi179 – 206Combined sources28
    Beta strandi211 – 215Combined sources5
    Helixi219 – 224Combined sources6
    Beta strandi228 – 230Combined sources3
    Helixi234 – 244Combined sources11

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2GTDX-ray2.00A/B/C/D/E/F1-245[»]
    3BEXX-ray1.51A/B/C/D/E/F1-246[»]
    3BF1X-ray2.30A/B/C/D/E/F1-246[»]
    3BF3X-ray1.63A/B/C/D/E/F1-246[»]
    ProteinModelPortaliQ9WZY5.
    SMRiQ9WZY5.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9WZY5.

    Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni103 – 106Substrate bindingBy similarity4

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiENOG4105CGM. Bacteria.
    COG1521. LUCA.
    InParanoidiQ9WZY5.
    KOiK03525.
    OMAiHEPWLTL.

    Family and domain databases

    HAMAPiMF_01274. Pantothen_kinase_3. 1 hit.
    InterProiIPR004619. Type_III_PanK.
    [Graphical view]
    PfamiPF03309. Pan_kinase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00671. baf. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9WZY5-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MYLLVDVGNT HSVFSITEDG KTFRRWRLST GVFQTEDELF SHLHPLLGDA
    60 70 80 90 100
    MREIKGIGVA SVVPTQNTVI ERFSQKYFHI SPIWVKAKNG CVKWNVKNPS
    110 120 130 140 150
    EVGADRVANV VAFVKEYGKN GIIIDMGTAT TVDLVVNGSY EGGAILPGFF
    160 170 180 190 200
    MMVHSLFRGT AKLPLVEVKP ADFVVGKDTE ENIRLGVVNG SVYALEGIIG
    210 220 230 240
    RIKEVYGDLP VVLTGGQSKI VKDMIKHEIF DEDLTIKGVY HFCFGD
    Length:246
    Mass (Da):27,154
    Last modified:November 1, 1999 - v1
    Checksum:i9E0309AD462CF266
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AE000512 Genomic DNA. Translation: AAD35964.1.
    PIRiD72320.
    RefSeqiNP_228691.1. NC_000853.1.
    WP_004080709.1. NZ_CP011107.1.

    Genome annotation databases

    EnsemblBacteriaiAAD35964; AAD35964; TM_0883.
    GeneIDi898557.
    KEGGitma:TM0883.
    PATRICi23936697. VBITheMar51294_0897.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AE000512 Genomic DNA. Translation: AAD35964.1.
    PIRiD72320.
    RefSeqiNP_228691.1. NC_000853.1.
    WP_004080709.1. NZ_CP011107.1.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2GTDX-ray2.00A/B/C/D/E/F1-245[»]
    3BEXX-ray1.51A/B/C/D/E/F1-246[»]
    3BF1X-ray2.30A/B/C/D/E/F1-246[»]
    3BF3X-ray1.63A/B/C/D/E/F1-246[»]
    ProteinModelPortaliQ9WZY5.
    SMRiQ9WZY5.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi243274.TM0883.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblBacteriaiAAD35964; AAD35964; TM_0883.
    GeneIDi898557.
    KEGGitma:TM0883.
    PATRICi23936697. VBITheMar51294_0897.

    Phylogenomic databases

    eggNOGiENOG4105CGM. Bacteria.
    COG1521. LUCA.
    InParanoidiQ9WZY5.
    KOiK03525.
    OMAiHEPWLTL.

    Enzyme and pathway databases

    UniPathwayiUPA00241; UER00352.
    BRENDAi2.7.1.33. 6331.
    SABIO-RKQ9WZY5.

    Miscellaneous databases

    EvolutionaryTraceiQ9WZY5.

    Family and domain databases

    HAMAPiMF_01274. Pantothen_kinase_3. 1 hit.
    InterProiIPR004619. Type_III_PanK.
    [Graphical view]
    PfamiPF03309. Pan_kinase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00671. baf. 1 hit.
    ProtoNetiSearch...

    Entry informationi

    Entry nameiCOAX_THEMA
    AccessioniPrimary (citable) accession number: Q9WZY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: November 1, 1999
    Last modified: November 2, 2016
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.