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Protein

Ribosomal RNA small subunit methyltransferase H

Gene

rsmH

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + N(4)-methylcytosine(1402) in 16S rRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei55 – 551S-adenosyl-L-methionine1 Publication
Binding sitei82 – 821S-adenosyl-L-methionine; via amide nitrogen1 Publication
Binding sitei103 – 1031S-adenosyl-L-methionine1 Publication
Binding sitei110 – 1101S-adenosyl-L-methionine1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase HUniRule annotation (EC:2.1.1.199UniRule annotation)
Alternative name(s):
16S rRNA m(4)C1402 methyltransferaseUniRule annotation
rRNA (cytosine-N(4)-)-methyltransferase RsmHUniRule annotation
Gene namesi
Name:rsmHUniRule annotation
Synonyms:mraW
Ordered Locus Names:TM_0872
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Ribosomal RNA small subunit methyltransferase HPRO_0000108732Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0872.

Structurei

Secondary structure

1
299
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi13 – 208Combined sources
Beta strandi27 – 304Combined sources
Helixi37 – 459Combined sources
Beta strandi50 – 567Combined sources
Helixi58 – 6710Combined sources
Helixi69 – 713Combined sources
Turni72 – 743Combined sources
Beta strandi75 – 795Combined sources
Helixi82 – 843Combined sources
Helixi85 – 917Combined sources
Beta strandi97 – 1037Combined sources
Helixi108 – 1125Combined sources
Beta strandi118 – 1225Combined sources
Helixi138 – 1447Combined sources
Helixi147 – 15610Combined sources
Turni161 – 1633Combined sources
Helixi164 – 17310Combined sources
Helixi180 – 19011Combined sources
Helixi193 – 1986Combined sources
Helixi205 – 21612Combined sources
Helixi218 – 22811Combined sources
Helixi229 – 2324Combined sources
Beta strandi233 – 24513Combined sources
Helixi246 – 25813Combined sources
Beta strandi260 – 2656Combined sources
Helixi274 – 2796Combined sources
Helixi281 – 2833Combined sources
Beta strandi287 – 2937Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M6YX-ray1.90A/B1-299[»]
1N2XX-ray1.90A/B1-299[»]
ProteinModelPortaliQ9WZX6.
SMRiQ9WZX6. Positions 2-294.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WZX6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni36 – 383S-adenosyl-L-methionine binding1 Publication

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RsmH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGJ. Bacteria.
COG0275. LUCA.
InParanoidiQ9WZX6.
KOiK03438.
OMAiHVPVMLQ.

Family and domain databases

Gene3Di1.10.150.170. 1 hit.
3.40.50.150. 2 hits.
HAMAPiMF_01007. 16SrRNA_methyltr_H. 1 hit.
InterProiIPR002903. RsmH.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11265. PTHR11265. 1 hit.
PfamiPF01795. Methyltransf_5. 1 hit.
[Graphical view]
PIRSFiPIRSF004486. MraW. 1 hit.
SUPFAMiSSF53335. SSF53335. 2 hits.
SSF81799. SSF81799. 1 hit.
TIGRFAMsiTIGR00006. TIGR00006. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WZX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKYSQRHIP VMVREVIEFL KPEDEKIILD CTVGEGGHSR AILEHCPGCR
60 70 80 90 100
IIGIDVDSEV LRIAEEKLKE FSDRVSLFKV SYREADFLLK TLGIEKVDGI
110 120 130 140 150
LMDLGVSTYQ LKGENRGFTF EREEPLDMRM DLESEVTAQK VLNELPEEEL
160 170 180 190 200
ARIIFEYGEE KRFARRIARK IVENRPLNTT LDLVKAVREA LPSYEIRRRK
210 220 230 240 250
RHFATKTFQA IRIYVNRELE NLKEFLKKAE DLLNPGGRIV VISFHSLEDR
260 270 280 290
IVKETFRNSK KLRILTEKPV RPSEEEIREN PRARSGRLRA AERIEEGGD
Length:299
Mass (Da):34,893
Last modified:November 1, 1999 - v1
Checksum:i790BBC2F3BB271F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35954.1.
PIRiC72323.
RefSeqiNP_228681.1. NC_000853.1.
WP_004080729.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD35954; AAD35954; TM_0872.
GeneIDi898545.
KEGGitma:TM0872.
tmi:THEMA_00275.
tmw:THMA_0894.
PATRICi23936672. VBITheMar51294_0885.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35954.1.
PIRiC72323.
RefSeqiNP_228681.1. NC_000853.1.
WP_004080729.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M6YX-ray1.90A/B1-299[»]
1N2XX-ray1.90A/B1-299[»]
ProteinModelPortaliQ9WZX6.
SMRiQ9WZX6. Positions 2-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0872.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35954; AAD35954; TM_0872.
GeneIDi898545.
KEGGitma:TM0872.
tmi:THEMA_00275.
tmw:THMA_0894.
PATRICi23936672. VBITheMar51294_0885.

Phylogenomic databases

eggNOGiENOG4105CGJ. Bacteria.
COG0275. LUCA.
InParanoidiQ9WZX6.
KOiK03438.
OMAiHVPVMLQ.

Miscellaneous databases

EvolutionaryTraceiQ9WZX6.

Family and domain databases

Gene3Di1.10.150.170. 1 hit.
3.40.50.150. 2 hits.
HAMAPiMF_01007. 16SrRNA_methyltr_H. 1 hit.
InterProiIPR002903. RsmH.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11265. PTHR11265. 1 hit.
PfamiPF01795. Methyltransf_5. 1 hit.
[Graphical view]
PIRSFiPIRSF004486. MraW. 1 hit.
SUPFAMiSSF53335. SSF53335. 2 hits.
SSF81799. SSF81799. 1 hit.
TIGRFAMsiTIGR00006. TIGR00006. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRSMH_THEMA
AccessioniPrimary (citable) accession number: Q9WZX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.