Q9WZW1 (Q9WZW1_THEMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Riboflavin kinase/FMN adenylyltransferase EMBL AAD35939.1

Gene names

Ordered Locus Names:

TM_0857

Organism

Thermotoga maritima

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	FMN PDB 1T6Y Flavoprotein PDB 1T6Y Nucleotide-binding PDB 1T6Y PDB 1T6X
Molecular function	Kinase EMBL AAD35939.1 Nucleotidyltransferase EMBL AAD35939.1 Transferase
Technical term	3D-structure PDB 1T6Y PDB 1T6X PDB 1MRZ PDB 1S4M PDB 2I1L PDB 1T6Z Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	riboflavin biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	FMN adenylyltransferase activity Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW riboflavin kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	7 – 8	2	AMP PDB 1T6Y
	Nucleotide binding	12 – 15	4	AMP PDB 1T6Y
	Nucleotide binding	99 – 101	3	AMP PDB 1T6Y
	Nucleotide binding	127 – 128	2	AMP PDB 1T6Y
	Nucleotide binding	179 – 182	4	ADP PDB 1T6Y PDB 1T6X
	Nucleotide binding	231 – 242	12	ADP PDB 1T6Y PDB 1T6X
	Nucleotide binding	255 – 258	4	FMN PDB 1T6Y
Sites
	Binding site	135	1	AMP; via carbonyl oxygen PDB 1T6Y
	Binding site	215	1	FMN PDB 1T6Y

Sequences

	Sequence		Length	Mass (Da)
	Q9WZW1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 42B56B582C03BEB4	FASTA	293	33,614
	10 20 30 40 50 60 MVVSIGVFDG VHIGHQKVLR TMKEIAFFRK DDSLIYTISY PPEYFLPDFP GLLMTVESRV 70 80 90 100 110 120 EMLSRYARTV VLDFFRIKDL TPEGFVERYL SGVSAVVVGR DFRFGKNASG NASFLRKKGV 130 140 150 160 170 180 EVYEIEDVVV QGKRVSSSLI RNLVQEGRVE EIPAYLGRYF EIEGIVHKDR EFGRKLGFPT 190 200 210 220 230 240 ANIDRGNEKL VDLKRGVYLV RVHLPDGKKK FGVMNVGFRP TVGDARNVKY EVYILDFEGD 250 260 270 280 290 LYGQRLKLEV LKFMRDEKKF DSIEELKAAI DQDVKSARNM IDDIINSKFE KEG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
[2]	"Crystal structure of a flavin-binding protein from Thermotoga maritima." Wang W., Kim R., Jancarik J., Yokota H., Kim S.H. Proteins 52:633-635(2003) [PubMed: 12910462] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS).
[3]	"Crystal structure of ADP bound FAD synthetase." Shin D.H., Wang W., Kim R., Yokota H., Kim S.-H. Submitted (MAY-2004) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS).
[4]	"Crystal structure of the C2 form of FAD synthetase from Thermotoga maritima." Wang W., Shin D.H., Yokota H., Kim R., Kim S.-H. Submitted (AUG-2006) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS).
[5]	"Crystal structure of flavin binding to FAD synthetase of Thermotoga maritima." Wang W., Kim R., Yokota H., Kim S.H. Proteins 58:246-248(2005) [PubMed: 15468322] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000512 Genomic DNA. Translation: AAD35939.1.

PIR

B72325.

RefSeq

NP_228666.1. NC_000853.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1MRZ	X-ray	1.90	A/B	1-293	[»]
1S4M	X-ray	2.10	A/B	1-293	[»]
1T6X	X-ray	2.29	A/B	1-293	[»]
1T6Y	X-ray	2.80	A/B	1-293	[»]
1T6Z	X-ray	2.40	A/B	1-293	[»]
2I1L	X-ray	2.50	A/B	1-293	[»]

ProteinModelPortal

Q9WZW1.

SMR

Q9WZW1. Positions 1-288.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

898530.

GenomeReviews

Gene locus TM_0857 in contig AE000512_GR.

KEGG

tma:TM0857.

NMPDR

fig|243274.1.peg.850.

PATRIC

23936642. VBITheMar51294_0870.

TIGR

TM_0857.

Phylogenomic databases

HOGENOM

HBG465096.

OMA

TFDPHPA.

PhylomeDB

Q9WZW1.

ProtClustDB

CLSK875429.

Enzyme and pathway databases

BioCyc

TMAR243274:TM_0857-MONOMER.

Family and domain databases

InterPro

IPR015864. FAD_synthase.
IPR023468. Riboflavin_kinase.
IPR002606. Riboflavin_kinase_bac.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023465. Riboflavin_kinase_domain.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]

Gene3D

G3DSA:2.40.30.30. Riboflavin_kinase. 1 hit.
G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.

KO

K11753.

PANTHER

PTHR22749. Riboflavin_kinase. 1 hit.

Pfam

PF06574. FAD_syn. 1 hit.
PF01687. Flavokinase. 1 hit.
[Graphical view]

PIRSF

PIRSF004491. FAD_Synth. 1 hit.

SMART

SM00904. Flavokinase. 1 hit.
[Graphical view]

SUPFAM

SSF82114. Riboflavin_kinase. 1 hit.

TIGRFAMs

TIGR00083. RibF. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q9WZW1_THEMA

Accession

Primary (citable) accession number: Q9WZW1

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	December 14, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)