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Protein

Riboflavin biosynthesis protein

Gene

TM_0857

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + FMN = diphosphate + FAD.UniRule annotation
ATP + riboflavin = ADP + FMN.UniRule annotation

Pathwayi: FAD biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FAD from FMN.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Riboflavin biosynthesis protein (Tmari_0859), Riboflavin biosynthesis protein (TM_0857)
This subpathway is part of the pathway FAD biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FAD from FMN, the pathway FAD biosynthesis and in Cofactor biosynthesis.

Pathwayi: FMN biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FMN from riboflavin (ATP route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Riboflavin biosynthesis protein (Tmari_0859), Riboflavin biosynthesis protein (TM_0857)
This subpathway is part of the pathway FMN biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FMN from riboflavin (ATP route), the pathway FMN biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei135AMP; via carbonyl oxygenCombined sources1
Binding sitei215FMNCombined sources1
Binding sitei264FMNCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 8AMPCombined sources2
Nucleotide bindingi12 – 15AMPCombined sources4
Nucleotide bindingi99 – 101AMPCombined sources3
Nucleotide bindingi127 – 128AMPCombined sources2
Nucleotide bindingi179 – 182ADPCombined sources4
Nucleotide bindingi231 – 242ADPCombined sourcesAdd BLAST12
Nucleotide bindingi255 – 258FMNCombined sources4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, NucleotidyltransferaseUniRule annotationImported, Transferase
LigandATP-bindingUniRule annotation, FADUniRule annotation, Flavoprotein, FMNUniRule annotationCombined sources, Nucleotide-binding

Enzyme and pathway databases

BioCyciTMAR243274:G1H0Q-70-MONOMER
UniPathwayiUPA00276; UER00406
UPA00277; UER00407

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin biosynthesis proteinUniRule annotation
Including the following 2 domains:
Riboflavin kinaseUniRule annotation (EC:2.7.1.26UniRule annotation)
Alternative name(s):
FlavokinaseUniRule annotation
FMN adenylyltransferaseUniRule annotation (EC:2.7.7.2UniRule annotation)
Alternative name(s):
FAD pyrophosphorylaseUniRule annotation
FAD synthaseUniRule annotation
Gene namesi
Ordered Locus Names:TM_0857Imported
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Imported
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Pathology & Biotechi

Chemistry databases

DrugBankiDB04345 7,8-dimethylalloxazine
DB04272 Citric Acid
DB03247 Flavin mononucleotide

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0857

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MRZX-ray1.90A/B1-293[»]
1S4MX-ray2.10A/B1-293[»]
1T6XX-ray2.29A/B1-293[»]
1T6YX-ray2.80A/B1-293[»]
1T6ZX-ray2.40A/B1-293[»]
2I1LX-ray2.50A/B1-293[»]
SMRiQ9WZW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DTN Bacteria
COG0196 LUCA
KOiK11753
OMAiHRGHQAI

Family and domain databases

Gene3Di2.40.30.30, 1 hit
3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR015864 FAD_synthase
IPR023468 Riboflavin_kinase
IPR002606 Riboflavin_kinase_bac
IPR015865 Riboflavin_kinase_bac/euk
IPR023465 Riboflavin_kinase_dom_sf
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR22749 PTHR22749, 1 hit
PfamiView protein in Pfam
PF06574 FAD_syn, 1 hit
PF01687 Flavokinase, 1 hit
PIRSFiPIRSF004491 FAD_Synth, 1 hit
SMARTiView protein in SMART
SM00904 Flavokinase, 1 hit
SUPFAMiSSF82114 SSF82114, 1 hit
TIGRFAMsiTIGR00083 ribF, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WZW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVSIGVFDG VHIGHQKVLR TMKEIAFFRK DDSLIYTISY PPEYFLPDFP
60 70 80 90 100
GLLMTVESRV EMLSRYARTV VLDFFRIKDL TPEGFVERYL SGVSAVVVGR
110 120 130 140 150
DFRFGKNASG NASFLRKKGV EVYEIEDVVV QGKRVSSSLI RNLVQEGRVE
160 170 180 190 200
EIPAYLGRYF EIEGIVHKDR EFGRKLGFPT ANIDRGNEKL VDLKRGVYLV
210 220 230 240 250
RVHLPDGKKK FGVMNVGFRP TVGDARNVKY EVYILDFEGD LYGQRLKLEV
260 270 280 290
LKFMRDEKKF DSIEELKAAI DQDVKSARNM IDDIINSKFE KEG
Length:293
Mass (Da):33,614
Last modified:November 1, 1999 - v1
Checksum:i42B56B582C03BEB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA Translation: AAD35939.1
PIRiB72325
RefSeqiNP_228666.1, NC_000853.1
WP_004080749.1, NZ_CP011107.1

Genome annotation databases

EnsemblBacteriaiAAD35939; AAD35939; TM_0857
AGL49784; AGL49784; Tmari_0859
GeneIDi898530
KEGGitma:TM0857
tmi:THEMA_00350
tmw:THMA_0879
PATRICifig|243274.17.peg.858

Similar proteinsi

Entry informationi

Entry nameiQ9WZW1_THEMA
AccessioniPrimary (citable) accession number: Q9WZW1
Secondary accession number(s): G4FCW7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

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