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Protein

tRNA pseudouridine synthase B

Gene

truB

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(55) = tRNA pseudouridine(55).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei39NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Enzyme and pathway databases

BRENDAi5.4.99.25 6331

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase BUniRule annotation (EC:5.4.99.25UniRule annotation)
Alternative name(s):
tRNA pseudouridine(55) synthase1 PublicationUniRule annotation
Short name:
Psi55 synthaseUniRule annotation
tRNA pseudouridylate synthaseUniRule annotation
tRNA-uridine isomeraseUniRule annotation
Gene namesi
Name:truB1 PublicationUniRule annotation
Ordered Locus Names:TM_0856
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001219291 – 309tRNA pseudouridine synthase BAdd BLAST309

Proteomic databases

PRIDEiQ9WZW0

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0856

Structurei

Secondary structure

1309
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 10Combined sources7
Beta strandi12 – 14Combined sources3
Helixi16 – 26Combined sources11
Beta strandi32 – 36Combined sources5
Beta strandi43 – 50Combined sources8
Helixi51 – 60Combined sources10
Beta strandi65 – 73Combined sources9
Beta strandi75 – 81Combined sources7
Beta strandi86 – 89Combined sources4
Helixi96 – 104Combined sources9
Beta strandi105 – 112Combined sources8
Beta strandi116 – 119Combined sources4
Beta strandi121 – 126Combined sources6
Helixi127 – 132Combined sources6
Beta strandi137 – 139Combined sources3
Beta strandi142 – 155Combined sources14
Beta strandi158 – 165Combined sources8
Helixi171 – 181Combined sources11
Beta strandi186 – 196Combined sources11
Helixi201 – 203Combined sources3
Turni207 – 209Combined sources3
Helixi212 – 218Combined sources7
Helixi222 – 224Combined sources3
Beta strandi231 – 233Combined sources3
Turni236 – 238Combined sources3
Helixi239 – 242Combined sources4
Turni243 – 245Combined sources3
Beta strandi248 – 252Combined sources5
Beta strandi253 – 255Combined sources3
Beta strandi264 – 268Combined sources5
Beta strandi270 – 272Combined sources3
Beta strandi274 – 282Combined sources9
Helixi287 – 290Combined sources4
Beta strandi291 – 294Combined sources4
Beta strandi298 – 305Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R3EX-ray2.10A1-309[»]
1ZE1X-ray2.90A/B/C/D1-309[»]
1ZE2X-ray3.00A/B1-309[»]
2AB4X-ray2.40A1-309[»]
ProteinModelPortaliQ9WZW0
SMRiQ9WZW0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WZW0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini229 – 306PUAUniRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0T Bacteria
COG0130 LUCA
InParanoidiQ9WZW0
KOiK03177
OMAiVDCSKGT

Family and domain databases

Gene3Di2.30.130.10, 1 hit
HAMAPiMF_01080 TruB_bact, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR002501 PsdUridine_synth_N
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
IPR014780 tRNA_psdUridine_synth_TruB
IPR032819 TruB_C
PANTHERiPTHR13767 PTHR13767, 1 hit
PfamiView protein in Pfam
PF01472 PUA, 1 hit
PF16198 TruB_C_2, 1 hit
PF01509 TruB_N, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00431 TruB, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WZW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHGILVAYK PKGPTSHDVV DEVRKKLKTR KVGHGGTLDP FACGVLIIGV
60 70 80 90 100
NQGTRILEFY KDLKKVYWVK MRLGLITETF DITGEVVEER ECNVTEEEIR
110 120 130 140 150
EAIFSFVGEY DQVPPAYSAK KYKGERLYKL AREGKIINLP PKRVKIFKIW
160 170 180 190 200
DVNIEGRDVS FRVEVSPGTY IRSLCMDIGY KLGCGATAVE LVRESVGPHT
210 220 230 240 250
IEESLNVFEA APEEIENRII PLEKCLEWLP RVVVHQESTK MILNGSQIHL
260 270 280 290 300
EMLKEWDGFK KGEVVRVFNE EGRLLALAEA ERNSSFLETL RKHERNERVL

TLRKVFNTR
Length:309
Mass (Da):35,459
Last modified:November 1, 1999 - v1
Checksum:i04825FD6D643CE9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA Translation: AAD35938.1
PIRiA72325
RefSeqiNP_228665.1, NC_000853.1
WP_004080766.1, NZ_CP011107.1

Genome annotation databases

EnsemblBacteriaiAAD35938; AAD35938; TM_0856
GeneIDi898529
KEGGitma:TM0856

Similar proteinsi

Entry informationi

Entry nameiTRUB_THEMA
AccessioniPrimary (citable) accession number: Q9WZW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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