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Protein
Submitted name:

Osmosensitive K+ channel histidine kinase KdpD

Gene

TM_0853

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei411 – 4111ADPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi380 – 3845ADPCombined sources
Nucleotide bindingi430 – 4345ADPCombined sources
Nucleotide bindingi442 – 4465ADPCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelImported, KinaseSAAS annotationImported, Transferase

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-883-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Osmosensitive K+ channel histidine kinase KdpDImported (EC:2.7.3.-Imported)
Submitted name:
Sensor histidine kinaseImported
Gene namesi
Ordered Locus Names:TM_0853Imported
ORF Names:Tmari_0855Imported
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Imported
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000013901 Componenti: Chromosome
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi330 ↔ 359Combined sources

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TM_0468Q9WYT94EBI-2464828,EBI-2464826

Protein-protein interaction databases

DIPiDIP-54544N.
STRINGi243274.TM0853.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2C2AX-ray1.90A233-489[»]
3DGEX-ray2.80A/B232-489[»]
4JASX-ray3.00A232-489[»]
4JAUX-ray2.70A232-489[»]
4JAVX-ray3.10A/B232-489[»]
4KP4X-ray3.00A/B271-290[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini257 – 480224Histidine kinaseInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
KOiK02484.
OMAiNEGIFVL.
OrthoDBiEOG6G4VQG.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WZV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEIKEQNNR LFLLLSIMIM EFSNAKTESD ILQGLLNLVR KVVDIKEVVL
60 70 80 90 100
VDENKRKIWG RDIDIKRFEE FIDWSIRQSN PVFVEDELGY VGIVPVVKQD
110 120 130 140 150
RMFGSLIVLL NHQPSMEETE IFKVLSFLSA VVLENIKLYR ELEETYNYVN
160 170 180 190 200
VILNGLPEGI FVYSNGEIKF QNEKFKEENF PDEVLRKAIS LSEEAISLRT
210 220 230 240 250
QRVGEVISGE EFFSITSIPL ILGSEVQALT IVENVTESKE LERLKRIDRM
260 270 280 290 300
KTEFIANISH ELRTPLTAIK AYAETIYNSL GELDLSTLKE FLEVIIDQSN
310 320 330 340 350
HLENLLNELL DFSRLERKSL QINREKVDLC DLVESAVNAI KEFASSHNVN
360 370 380 390 400
VLFESNVPCP VEAYIDPTRI RQVLLNLLNN GVKYSKKDAP DKYVKVILDE
410 420 430 440 450
KDGGVLIIVE DNGIGIPDHA KDRIFEQFYR VDSSLTYEVP GTGLGLAITK
460 470 480
EIVELHGGRI WVESEVGKGS RFFVWIPKDR AGEDNRQDN
Length:489
Mass (Da):56,017
Last modified:November 1, 1999 - v1
Checksum:i40F19F843A4EDDB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35935.1.
CP004077 Genomic DNA. Translation: AGL49780.1.
PIRiF72324.
RefSeqiNP_228662.1. NC_000853.1.
WP_004080773.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD35935; AAD35935; TM_0853.
AGL49780; AGL49780; Tmari_0855.
GeneIDi898525.
KEGGitma:TM0853.
tmi:THEMA_00370.
tmm:Tmari_0855.
tmw:THMA_0875.
PATRICi23936634. VBITheMar51294_0866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35935.1.
CP004077 Genomic DNA. Translation: AGL49780.1.
PIRiF72324.
RefSeqiNP_228662.1. NC_000853.1.
WP_004080773.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2C2AX-ray1.90A233-489[»]
3DGEX-ray2.80A/B232-489[»]
4JASX-ray3.00A232-489[»]
4JAUX-ray2.70A232-489[»]
4JAVX-ray3.10A/B232-489[»]
4KP4X-ray3.00A/B271-290[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-54544N.
STRINGi243274.TM0853.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35935; AAD35935; TM_0853.
AGL49780; AGL49780; Tmari_0855.
GeneIDi898525.
KEGGitma:TM0853.
tmi:THEMA_00370.
tmm:Tmari_0855.
tmw:THMA_0875.
PATRICi23936634. VBITheMar51294_0866.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
KOiK02484.
OMAiNEGIFVL.
OrthoDBiEOG6G4VQG.

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-883-MONOMER.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099Imported and MSB8Imported.
  2. "The genome organization of Thermotoga maritima reflects its lifestyle."
    Latif H., Lerman J.A., Portnoy V.A., Tarasova Y., Nagarajan H., Schrimpe-Rutledge A.C., Smith R.D., Adkins J.N., Lee D.H., Qiu Y., Zengler K.
    PLoS Genet. 9:E1003485-E1003485(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099Imported and MSB8Imported.

Entry informationi

Entry nameiQ9WZV7_THEMA
AccessioniPrimary (citable) accession number: Q9WZV7
Secondary accession number(s): G4FCX1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.