Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heat-inducible transcription repressor HrcA

Gene

hrcA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Stress response, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Heat-inducible transcription repressor HrcAUniRule annotation
Gene namesi
Name:hrcAUniRule annotation
Ordered Locus Names:TM_0851
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Heat-inducible transcription repressor HrcAPRO_0000182552Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0851.

Structurei

Secondary structure

1
338
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi17 – 3317Combined sources
Helixi39 – 457Combined sources
Helixi52 – 6413Combined sources
Beta strandi67 – 693Combined sources
Beta strandi77 – 793Combined sources
Helixi81 – 9414Combined sources
Turni95 – 973Combined sources
Helixi103 – 1064Combined sources
Helixi116 – 13116Combined sources
Beta strandi134 – 1385Combined sources
Helixi142 – 1443Combined sources
Beta strandi149 – 1546Combined sources
Beta strandi156 – 16611Combined sources
Beta strandi169 – 1779Combined sources
Helixi184 – 19512Combined sources
Helixi200 – 2056Combined sources
Helixi209 – 2124Combined sources
Helixi215 – 22410Combined sources
Beta strandi230 – 2345Combined sources
Helixi236 – 2416Combined sources
Helixi247 – 25610Combined sources
Helixi260 – 2667Combined sources
Beta strandi269 – 2757Combined sources
Helixi276 – 2794Combined sources
Helixi282 – 2843Combined sources
Beta strandi287 – 29610Combined sources
Beta strandi299 – 31214Combined sources
Helixi314 – 33421Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1STZX-ray2.20A/B/C1-338[»]
ProteinModelPortaliQ9WZV5.
SMRiQ9WZV5. Positions 14-336.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WZV5.

Family & Domainsi

Sequence similaritiesi

Belongs to the HrcA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI8. Bacteria.
COG1420. LUCA.
InParanoidiQ9WZV5.
KOiK03705.
OMAiLNWEEIE.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.390.60. 1 hit.
HAMAPiMF_00081. HrcA. 1 hit.
InterProiIPR029016. GAF_dom-like.
IPR002571. HrcA.
IPR021153. HrcA_C.
IPR011991. WHTH_DNA-bd_dom.
IPR023120. WHTH_transcript_rep_HrcA_IDD.
[Graphical view]
PfamiPF01628. HrcA. 1 hit.
[Graphical view]
PIRSFiPIRSF005485. HrcA. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF55781. SSF55781. 1 hit.
TIGRFAMsiTIGR00331. hrcA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WZV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLNRKNNE ALKKLNDRQR KVLYCIVREY IENKKPVSSQ RVLEVSNIEF
60 70 80 90 100
SSATIRNDMK KLEYLGYIYQ PHTSAGRIPT DKGLRFYYEE MLKISKETSE
110 120 130 140 150
ADLAVETFKS MPLADPEKVL FLAGNLLARL TEGYVLIERP NTRDLKILRV
160 170 180 190 200
MLIPVSEDYL IFSILTEFGV SKVTPIKTQE RLNWEEIERQ LNFLLRGRTV
210 220 230 240 250
GEVLMGKIES LKGSGFLRLI ESLIGETVER YLDAGLENLL KDETLTLEDI
260 270 280 290 300
RNLLEEVKDQ KFLESLVGEG ITVRIGREIG RKKLEKFAVF SGKYFKGESP
310 320 330
IGSVYLFTSK VTKYDRNHRV FEYILNRLSE YFTSTSRR
Length:338
Mass (Da):39,307
Last modified:November 1, 1999 - v1
Checksum:i02A505A546C313AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35933.1.
PIRiD72327.
RefSeqiNP_228660.1. NC_000853.1.
WP_004080775.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD35933; AAD35933; TM_0851.
GeneIDi898522.
KEGGitma:TM0851.
tmi:THEMA_00385.
tmw:THMA_0872.
PATRICi23936628. VBITheMar51294_0864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35933.1.
PIRiD72327.
RefSeqiNP_228660.1. NC_000853.1.
WP_004080775.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1STZX-ray2.20A/B/C1-338[»]
ProteinModelPortaliQ9WZV5.
SMRiQ9WZV5. Positions 14-336.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0851.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35933; AAD35933; TM_0851.
GeneIDi898522.
KEGGitma:TM0851.
tmi:THEMA_00385.
tmw:THMA_0872.
PATRICi23936628. VBITheMar51294_0864.

Phylogenomic databases

eggNOGiENOG4105CI8. Bacteria.
COG1420. LUCA.
InParanoidiQ9WZV5.
KOiK03705.
OMAiLNWEEIE.

Miscellaneous databases

EvolutionaryTraceiQ9WZV5.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.390.60. 1 hit.
HAMAPiMF_00081. HrcA. 1 hit.
InterProiIPR029016. GAF_dom-like.
IPR002571. HrcA.
IPR021153. HrcA_C.
IPR011991. WHTH_DNA-bd_dom.
IPR023120. WHTH_transcript_rep_HrcA_IDD.
[Graphical view]
PfamiPF01628. HrcA. 1 hit.
[Graphical view]
PIRSFiPIRSF005485. HrcA. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF55781. SSF55781. 1 hit.
TIGRFAMsiTIGR00331. hrcA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHRCA_THEMA
AccessioniPrimary (citable) accession number: Q9WZV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.