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Protein

Heat-inducible transcription repressor HrcA

Gene

hrcA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Stress response, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Heat-inducible transcription repressor HrcAUniRule annotation
Gene namesi
Name:hrcAUniRule annotation
Ordered Locus Names:TM_0851
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001825521 – 338Heat-inducible transcription repressor HrcAAdd BLAST338

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0851.

Structurei

Secondary structure

1338
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 33Combined sources17
Helixi39 – 45Combined sources7
Helixi52 – 64Combined sources13
Beta strandi67 – 69Combined sources3
Beta strandi77 – 79Combined sources3
Helixi81 – 94Combined sources14
Turni95 – 97Combined sources3
Helixi103 – 106Combined sources4
Helixi116 – 131Combined sources16
Beta strandi134 – 138Combined sources5
Helixi142 – 144Combined sources3
Beta strandi149 – 154Combined sources6
Beta strandi156 – 166Combined sources11
Beta strandi169 – 177Combined sources9
Helixi184 – 195Combined sources12
Helixi200 – 205Combined sources6
Helixi209 – 212Combined sources4
Helixi215 – 224Combined sources10
Beta strandi230 – 234Combined sources5
Helixi236 – 241Combined sources6
Helixi247 – 256Combined sources10
Helixi260 – 266Combined sources7
Beta strandi269 – 275Combined sources7
Helixi276 – 279Combined sources4
Helixi282 – 284Combined sources3
Beta strandi287 – 296Combined sources10
Beta strandi299 – 312Combined sources14
Helixi314 – 334Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1STZX-ray2.20A/B/C1-338[»]
ProteinModelPortaliQ9WZV5.
SMRiQ9WZV5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WZV5.

Family & Domainsi

Sequence similaritiesi

Belongs to the HrcA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI8. Bacteria.
COG1420. LUCA.
InParanoidiQ9WZV5.
KOiK03705.
OMAiLNWEEIE.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.390.60. 1 hit.
HAMAPiMF_00081. HrcA. 1 hit.
InterProiIPR029016. GAF_dom-like.
IPR002571. HrcA.
IPR021153. HrcA_C.
IPR011991. WHTH_DNA-bd_dom.
IPR023120. WHTH_transcript_rep_HrcA_IDD.
[Graphical view]
PfamiPF01628. HrcA. 1 hit.
[Graphical view]
PIRSFiPIRSF005485. HrcA. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF55781. SSF55781. 1 hit.
TIGRFAMsiTIGR00331. hrcA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WZV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLNRKNNE ALKKLNDRQR KVLYCIVREY IENKKPVSSQ RVLEVSNIEF
60 70 80 90 100
SSATIRNDMK KLEYLGYIYQ PHTSAGRIPT DKGLRFYYEE MLKISKETSE
110 120 130 140 150
ADLAVETFKS MPLADPEKVL FLAGNLLARL TEGYVLIERP NTRDLKILRV
160 170 180 190 200
MLIPVSEDYL IFSILTEFGV SKVTPIKTQE RLNWEEIERQ LNFLLRGRTV
210 220 230 240 250
GEVLMGKIES LKGSGFLRLI ESLIGETVER YLDAGLENLL KDETLTLEDI
260 270 280 290 300
RNLLEEVKDQ KFLESLVGEG ITVRIGREIG RKKLEKFAVF SGKYFKGESP
310 320 330
IGSVYLFTSK VTKYDRNHRV FEYILNRLSE YFTSTSRR
Length:338
Mass (Da):39,307
Last modified:November 1, 1999 - v1
Checksum:i02A505A546C313AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35933.1.
PIRiD72327.
RefSeqiNP_228660.1. NC_000853.1.
WP_004080775.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD35933; AAD35933; TM_0851.
GeneIDi898522.
KEGGitma:TM0851.
PATRICi23936628. VBITheMar51294_0864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35933.1.
PIRiD72327.
RefSeqiNP_228660.1. NC_000853.1.
WP_004080775.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1STZX-ray2.20A/B/C1-338[»]
ProteinModelPortaliQ9WZV5.
SMRiQ9WZV5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0851.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35933; AAD35933; TM_0851.
GeneIDi898522.
KEGGitma:TM0851.
PATRICi23936628. VBITheMar51294_0864.

Phylogenomic databases

eggNOGiENOG4105CI8. Bacteria.
COG1420. LUCA.
InParanoidiQ9WZV5.
KOiK03705.
OMAiLNWEEIE.

Miscellaneous databases

EvolutionaryTraceiQ9WZV5.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.390.60. 1 hit.
HAMAPiMF_00081. HrcA. 1 hit.
InterProiIPR029016. GAF_dom-like.
IPR002571. HrcA.
IPR021153. HrcA_C.
IPR011991. WHTH_DNA-bd_dom.
IPR023120. WHTH_transcript_rep_HrcA_IDD.
[Graphical view]
PfamiPF01628. HrcA. 1 hit.
[Graphical view]
PIRSFiPIRSF005485. HrcA. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF55781. SSF55781. 1 hit.
TIGRFAMsiTIGR00331. hrcA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHRCA_THEMA
AccessioniPrimary (citable) accession number: Q9WZV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.