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Protein

Heat-inducible transcription repressor HrcA

Gene

hrcA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processStress response, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Heat-inducible transcription repressor HrcAUniRule annotation
Gene namesi
Name:hrcAUniRule annotation
Ordered Locus Names:TM_0851
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001825521 – 338Heat-inducible transcription repressor HrcAAdd BLAST338

Proteomic databases

PRIDEiQ9WZV5

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0851

Structurei

Secondary structure

1338
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 33Combined sources17
Helixi39 – 45Combined sources7
Helixi52 – 64Combined sources13
Beta strandi67 – 69Combined sources3
Beta strandi77 – 79Combined sources3
Helixi81 – 94Combined sources14
Turni95 – 97Combined sources3
Helixi103 – 106Combined sources4
Helixi116 – 131Combined sources16
Beta strandi134 – 138Combined sources5
Helixi142 – 144Combined sources3
Beta strandi149 – 154Combined sources6
Beta strandi156 – 166Combined sources11
Beta strandi169 – 177Combined sources9
Helixi184 – 195Combined sources12
Helixi200 – 205Combined sources6
Helixi209 – 212Combined sources4
Helixi215 – 224Combined sources10
Beta strandi230 – 234Combined sources5
Helixi236 – 241Combined sources6
Helixi247 – 256Combined sources10
Helixi260 – 266Combined sources7
Beta strandi269 – 275Combined sources7
Helixi276 – 279Combined sources4
Helixi282 – 284Combined sources3
Beta strandi287 – 296Combined sources10
Beta strandi299 – 312Combined sources14
Helixi314 – 334Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1STZX-ray2.20A/B/C1-338[»]
ProteinModelPortaliQ9WZV5
SMRiQ9WZV5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WZV5

Family & Domainsi

Sequence similaritiesi

Belongs to the HrcA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI8 Bacteria
COG1420 LUCA
InParanoidiQ9WZV5
KOiK03705
OMAiLNWEEIE

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.30.390.60, 1 hit
3.30.450.40, 2 hits
HAMAPiMF_00081 HrcA, 1 hit
InterProiView protein in InterPro
IPR029016 GAF-like_dom_sf
IPR002571 HrcA
IPR021153 HrcA_C
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR023120 WHTH_transcript_rep_HrcA_IDD
PANTHERiPTHR34824 PTHR34824, 1 hit
PfamiView protein in Pfam
PF01628 HrcA, 1 hit
PIRSFiPIRSF005485 HrcA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
TIGRFAMsiTIGR00331 hrcA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WZV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLNRKNNE ALKKLNDRQR KVLYCIVREY IENKKPVSSQ RVLEVSNIEF
60 70 80 90 100
SSATIRNDMK KLEYLGYIYQ PHTSAGRIPT DKGLRFYYEE MLKISKETSE
110 120 130 140 150
ADLAVETFKS MPLADPEKVL FLAGNLLARL TEGYVLIERP NTRDLKILRV
160 170 180 190 200
MLIPVSEDYL IFSILTEFGV SKVTPIKTQE RLNWEEIERQ LNFLLRGRTV
210 220 230 240 250
GEVLMGKIES LKGSGFLRLI ESLIGETVER YLDAGLENLL KDETLTLEDI
260 270 280 290 300
RNLLEEVKDQ KFLESLVGEG ITVRIGREIG RKKLEKFAVF SGKYFKGESP
310 320 330
IGSVYLFTSK VTKYDRNHRV FEYILNRLSE YFTSTSRR
Length:338
Mass (Da):39,307
Last modified:November 1, 1999 - v1
Checksum:i02A505A546C313AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA Translation: AAD35933.1
PIRiD72327
RefSeqiNP_228660.1, NC_000853.1
WP_004080775.1, NZ_CP011107.1

Genome annotation databases

EnsemblBacteriaiAAD35933; AAD35933; TM_0851
GeneIDi898522
KEGGitma:TM0851

Similar proteinsi

Entry informationi

Entry nameiHRCA_THEMA
AccessioniPrimary (citable) accession number: Q9WZV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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