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Protein

Probable 2-phosphosulfolactate phosphatase

Gene

comB

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-phosphosulfolactate phosphatase (EC:3.1.3.71)
Gene namesi
Name:comB
Ordered Locus Names:TM_0797
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000814771 – 227Probable 2-phosphosulfolactate phosphataseAdd BLAST227

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0797.

Structurei

Secondary structure

1227
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Beta strandi15 – 20Combined sources6
Turni22 – 24Combined sources3
Helixi25 – 34Combined sources10
Beta strandi38 – 42Combined sources5
Helixi46 – 51Combined sources6
Beta strandi57 – 61Combined sources5
Helixi77 – 79Combined sources3
Helixi82 – 85Combined sources4
Beta strandi89 – 93Combined sources5
Helixi97 – 103Combined sources7
Beta strandi109 – 112Combined sources4
Helixi114 – 116Combined sources3
Helixi117 – 124Combined sources8
Beta strandi129 – 134Combined sources6
Helixi143 – 156Combined sources14
Helixi163 – 173Combined sources11
Helixi178 – 185Combined sources8
Helixi187 – 194Combined sources8
Helixi198 – 204Combined sources7
Beta strandi215 – 217Combined sources3
Beta strandi220 – 222Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YYVX-ray1.65A/B1-227[»]
2YZOX-ray1.85A/B1-227[»]
ProteinModelPortaliQ9WZQ4.
SMRiQ9WZQ4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WZQ4.

Family & Domainsi

Sequence similaritiesi

Belongs to the ComB family.Curated

Phylogenomic databases

eggNOGiENOG4108N5B. Bacteria.
COG2045. LUCA.
InParanoidiQ9WZQ4.
KOiK05979.
OMAiFRATSCM.

Family and domain databases

Gene3Di3.90.1560.10. 1 hit.
HAMAPiMF_00490. ComB. 1 hit.
InterProiIPR005238. ComB-like.
IPR022995. ProB_Pase_ComB.
[Graphical view]
PfamiPF04029. 2-ph_phosp. 1 hit.
[Graphical view]
SUPFAMiSSF142823. SSF142823. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WZQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDVVMAPCS PVECRTAVVI DVLRATSTIV TALSNGASGV IPVKTIEEAL
60 70 80 90 100
EKKKEGVLIC GERNAQKPKG FNLGNSPLEY RKEKISGKTI VLTTTNGTQV
110 120 130 140 150
IEKIRSEEII AASFLNLSAV VEYLKSKEDI LLVCAGTNGR FSLEDFLLAG
160 170 180 190 200
AIVKRLKRND LGDGAHAAER YFESVENTRE EIKKHSSHAK RLISLGFEND
210 220
IEFCTTEDLF KTVPALVNGV FILKEFP
Length:227
Mass (Da):24,857
Last modified:November 1, 1999 - v1
Checksum:iED32447E6140D9F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35879.1.
PIRiF72334.
RefSeqiNP_228606.1. NC_000853.1.
WP_004080870.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD35879; AAD35879; TM_0797.
GeneIDi898465.
KEGGitma:TM0797.
PATRICi23936514. VBITheMar51294_0809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35879.1.
PIRiF72334.
RefSeqiNP_228606.1. NC_000853.1.
WP_004080870.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YYVX-ray1.65A/B1-227[»]
2YZOX-ray1.85A/B1-227[»]
ProteinModelPortaliQ9WZQ4.
SMRiQ9WZQ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0797.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35879; AAD35879; TM_0797.
GeneIDi898465.
KEGGitma:TM0797.
PATRICi23936514. VBITheMar51294_0809.

Phylogenomic databases

eggNOGiENOG4108N5B. Bacteria.
COG2045. LUCA.
InParanoidiQ9WZQ4.
KOiK05979.
OMAiFRATSCM.

Miscellaneous databases

EvolutionaryTraceiQ9WZQ4.

Family and domain databases

Gene3Di3.90.1560.10. 1 hit.
HAMAPiMF_00490. ComB. 1 hit.
InterProiIPR005238. ComB-like.
IPR022995. ProB_Pase_ComB.
[Graphical view]
PfamiPF04029. 2-ph_phosp. 1 hit.
[Graphical view]
SUPFAMiSSF142823. SSF142823. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOMB_THEMA
AccessioniPrimary (citable) accession number: Q9WZQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.