Q9WZQ4 (COMB_THEMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 2-phosphosulfolactate phosphatase
EC=3.1.3.71

Gene names

Name:	comB
Ordered Locus Names:	TM_0797

Organism

Thermotoga maritima

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate. HAMAP MF_00490
Cofactor	Magnesium By similarity. HAMAP MF_00490
Sequence similarities	Belongs to the ComB family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	coenzyme M biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	2-phosphosulfolactate phosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 227

227

Probable 2-phosphosulfolactate phosphatase HAMAP MF_00490

PRO_0000081477

Secondary structure

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227

Helix Strand Turn

Details...

Beta strand

3 – 7

5

Beta strand

15 – 20

6

Turn

22 – 24

3

Helix

25 – 34

10

Beta strand

38 – 42

5

Helix

46 – 51

6

Beta strand

57 – 61

5

Helix

77 – 79

3

Helix

82 – 85

4

Beta strand

89 – 93

5

Helix

97 – 103

7

Beta strand

109 – 112

4

Helix

114 – 116

3

Helix

117 – 124

8

Beta strand

129 – 134

6

Helix

143 – 156

14

Helix

163 – 173

11

Helix

178 – 185

8

Helix

187 – 194

8

Helix

198 – 204

7

Beta strand

215 – 217

3

Beta strand

220 – 222

3

Sequences

	Sequence		Length	Mass (Da)
	Q9WZQ4 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: ED32447E6140D9F8	FASTA	227	24,857
	10 20 30 40 50 60 MVDVVMAPCS PVECRTAVVI DVLRATSTIV TALSNGASGV IPVKTIEEAL EKKKEGVLIC 70 80 90 100 110 120 GERNAQKPKG FNLGNSPLEY RKEKISGKTI VLTTTNGTQV IEKIRSEEII AASFLNLSAV 130 140 150 160 170 180 VEYLKSKEDI LLVCAGTNGR FSLEDFLLAG AIVKRLKRND LGDGAHAAER YFESVENTRE 190 200 210 220 EIKKHSSHAK RLISLGFEND IEFCTTEDLF KTVPALVNGV FILKEFP

References

[1]

"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000512 Genomic DNA. Translation: AAD35879.1.

PIR

F72334.

RefSeq

NP_228606.1. NC_000853.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2YYV	X-ray	1.65	A/B	1-227	[»]
2YZO	X-ray	1.85	A/B	1-227	[»]

ProteinModelPortal

Q9WZQ4.

SMR

Q9WZQ4. Positions 2-225.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

898465.

GenomeReviews

Gene locus TM_0797 in contig AE000512_GR.

KEGG

tma:TM0797.

NMPDR

fig|243274.1.peg.790.

PATRIC

23936514. VBITheMar51294_0809.

TIGR

TM_0797.

Phylogenomic databases

HOGENOM

HBG633644.

OMA

DFICSGY.

PhylomeDB

Q9WZQ4.

ProtClustDB

PRK00886.

Enzyme and pathway databases

BioCyc

TMAR243274:TM_0797-MONOMER.

Family and domain databases

HAMAP

MF_00490. ComB.
[Tree]

InterPro

IPR005238. 2-PSlactate_phosphatase.
IPR022995. Pase_ComB.
[Graphical view]

Gene3D

G3DSA:3.90.1560.10. 2-PSlactate_phosphatase. 1 hit.

KO

K05979.

Pfam

PF04029. 2-ph_phosp. 1 hit.
[Graphical view]

SUPFAM

SSF142823. SSF142823. 1 hit.

ProtoNet

Search...

Entry information

Entry name

COMB_THEMA

Accession

Primary (citable) accession number: Q9WZQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
Last sequence update:	November 1, 1999
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program