Alpha-glucosidase, putative - Thermotoga maritima

Preferred order of sections

Names and origin

Protein names

Submitted name:
Alpha-glucosidase, putative EMBL AAD35834.1

Gene names

Ordered Locus Names:

TM_0752

Organism

Thermotoga maritima

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	471 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	NAD PDB 1VJT Nucleotide-binding PDB 1VJT
Technical term	3D-structure PDB 1VJT Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	hydrolase activity, hydrolyzing O-glycosyl compounds Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Nucleotide binding

38 – 40

3

NAD PDB 1VJT

Nucleotide binding

85 – 86

2

NAD PDB 1VJT

Sites

Binding site

10

1

NAD PDB 1VJT

Binding site

160

1

NAD PDB 1VJT

Binding site

310

1

NAD PDB 1VJT

Sequences

Sequence

Length

Mass (Da)

Tools

Q9WZL1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 8C6921EB9978E9D8
Show »

FASTA

471

55,357

        10         20         30         40         50         60 
MKISIIGAGS VRFALQLVGD IAQTEELSRE DTHIYMMDVH ERRLNASYIL ARKYVEELNS 

        70         80         90        100        110        120 
PVKIVKTSSL DEAIDGADFI INTAYPYDPR YHDSGSQRWD EVTKVGEKHG YYRGIDSQEL 

       130        140        150        160        170        180 
NMVSTYTYVL SSYPDMKLAL EIAEKMKKMA PKAYLMQTAN PVFEITQAVR RWTGANIVGF 

       190        200        210        220        230        240 
CHGVAGVYEV FEKLDLDPEE VDWQVAGVNH GIWLNRFRYR GEDAYPLLDE WIEKKLPEWE 

       250        260        270        280        290        300 
PKNPWDTQMS PAAMDMYKFY GMLPIGDTVR NGSWKYHYNL ETKKKWFGKF GGIDNEVERP 

       310        320        330        340        350        360 
KFHEQLRRAR ERLIKLAEEV QQNPGMKLTE EHPEIFPKGK LSGEQHIPFI NAIANNKRVR 

       370        380        390        400        410        420 
LFLNVENQGT LKDFPDDVVM ELPVWVDCCG IHREKVEPDL THRIKIFYLW PRILRMEWNL 

       430        440        450        460        470 
EAYISRDRKV LEEILIRDPR TKSYEQIVQV LDEIFNLPFN EELRRYYKEK L

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
[2]	"Crystal structure of Alpha-glucosidase (TM0752) from Thermotoga maritima at 2.50 A resolution." Joint Center for Structural Genomics (JCSG) Submitted (MAR-2004) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH NAD.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000512 Genomic DNA. Translation: AAD35834.1.

PIR

F72337.

RefSeq

NP_228561.1. NC_000853.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1VJT	X-ray	2.50	A	1-471	[»]

ProteinModelPortal

Q9WZL1.

SMR

Q9WZL1. Positions 1-469.

ModBase

Search...

Protein family/group databases

CAZy

GH4. Glycoside Hydrolase Family 4.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

898420.

GenomeReviews

Gene locus TM_0752 in contig AE000512_GR.

KEGG

tma:TM0752.

NMPDR

fig|243274.1.peg.745.

PATRIC

23936426. VBITheMar51294_0765.

TIGR

TM_0752.

Phylogenomic databases

HOGENOM

HBG391782.

OMA

TICAGGI.

PhylomeDB

Q9WZL1.

ProtClustDB

CLSK875141.

Enzyme and pathway databases

BioCyc

TMAR243274:TM_0752-MONOMER.

Family and domain databases

InterPro

IPR001088. Glyco_hydro_4.
IPR022616. Glyco_hydro_4_C.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]

Gene3D

G3DSA:3.90.110.10. lact_mal_DH. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.

KO

K01187.

Pfam

PF02056. Glyco_hydro_4. 1 hit.
PF11975. Glyco_hydro_4C. 1 hit.
[Graphical view]

PRINTS

PR00732. GLHYDRLASE4.

SUPFAM

SSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q9WZL1_THEMA

Accession

Primary (citable) accession number: Q9WZL1

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	December 14, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)