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Q9WZF8

- TIG_THEMA

UniProt

Q9WZF8 - TIG_THEMA

Protein

Trigger factor

Gene

tig

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase By similarity.By similarity

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-HAMAP
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. protein folding Source: UniProtKB-HAMAP
    4. protein transport Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone, Isomerase, Rotamase

    Keywords - Biological processi

    Cell cycle, Cell division

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trigger factor (EC:5.2.1.8)
    Short name:
    TF
    Alternative name(s):
    PPIase
    Gene namesi
    Name:tig
    Ordered Locus Names:TM_0694
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    Subcellular locationi

    Cytoplasm
    Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Trigger factorPRO_0000179452Add
    BLAST

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    rpsGP385265EBI-2463534,EBI-2463521

    Protein-protein interaction databases

    IntActiQ9WZF8. 1 interaction.
    STRINGi243274.TM0694.

    Structurei

    Secondary structure

    1
    425
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 98
    Beta strandi12 – 187
    Helixi21 – 3616
    Beta strandi42 – 443
    Helixi51 – 588
    Helixi59 – 613
    Helixi62 – 7110
    Helixi74 – 774
    Turni78 – 803
    Beta strandi83 – 853
    Beta strandi88 – 947
    Beta strandi99 – 1079
    Beta strandi110 – 1123
    Helixi116 – 1183
    Beta strandi119 – 1246
    Helixi126 – 14419
    Beta strandi148 – 1503
    Beta strandi159 – 16810
    Beta strandi174 – 18310
    Helixi193 – 1964
    Beta strandi204 – 2118
    Beta strandi214 – 22815
    Helixi235 – 2395
    Beta strandi241 – 2444
    Helixi248 – 2547
    Helixi259 – 2624
    Helixi267 – 27812
    Helixi279 – 2824
    Beta strandi284 – 2863
    Helixi289 – 30517
    Helixi309 – 3146
    Helixi319 – 34729
    Helixi353 – 36715
    Helixi371 – 38010
    Helixi382 – 40221
    Beta strandi405 – 4106

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2NSAX-ray1.70A244-405[»]
    2NSBX-ray3.20A1-109[»]
    2NSCX-ray2.20A1-109[»]
    3GTYX-ray3.40X1-425[»]
    3GU0X-ray3.50A1-405[»]
    ProteinModelPortaliQ9WZF8.
    SMRiQ9WZF8. Positions 1-109, 244-406.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9WZF8.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini158 – 23174PPIase FKBP-typeAdd
    BLAST

    Domaini

    Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.By similarity

    Sequence similaritiesi

    Belongs to the FKBP-type PPIase family. Tig subfamily.Curated
    Contains 1 PPIase FKBP-type domain.Curated

    Phylogenomic databases

    eggNOGiCOG0544.
    KOiK03545.
    OMAiHAYQHIA.
    OrthoDBiEOG63VBX3.

    Family and domain databases

    Gene3Di1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPiMF_00303. Trigger_factor_Tig.
    InterProiIPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view]
    PfamiPF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003095. Trigger_factor. 1 hit.
    SUPFAMiSSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsiTIGR00115. tig. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9WZF8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVKELERDK NRVVLEYVFG AEEIAQAEDK AVRYLNQRVE IPGFRKGRIP    50
    KNVLKMKLGE EFQEYTLDFL MDLIPDTLKD RKLILSPIVT ERELKDVTAR 100
    VVVEVHEEPE VRIGDISKIE VEKVDEEKVL EKYVERRIED LRESHALLEP 150
    KEGPAEAGDL VRVNMEVYNE EGKKLTSREY EYVISEDEDR PFVKDLVGKK 200
    KGDVVEIERE YEGKKYTYKL EVEEVYKRTL PEIGDELAKS VNNEFETLEQ 250
    LKESLKKEGK EIYDVEMKES MREQLLEKLP EIVEIEISDR TLEILVNEAI 300
    NRLKREGRYE QIVSSYESEE KFREELKERI LDDIKRDRVI EVLAQEKGIS 350
    VNDEELEKEA EELAPFWGIS PDRAKSLVKA RQDLREELRW AILKRKVLDL 400
    LLQEVKVKVV EPKGEGDDSE GKEDN 425
    Length:425
    Mass (Da):49,898
    Last modified:November 1, 1999 - v1
    Checksum:iBEC16F20ACFDD922
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD35776.1.
    PIRiD72345.
    RefSeqiNP_228503.1. NC_000853.1.
    YP_007977044.1. NC_021214.1.
    YP_008990337.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD35776; AAD35776; TM_0694.
    GeneIDi898361.
    KEGGitma:TM0694.
    tmi:THEMA_01195.
    tmm:Tmari_0694.
    PATRICi23936306. VBITheMar51294_0706.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD35776.1 .
    PIRi D72345.
    RefSeqi NP_228503.1. NC_000853.1.
    YP_007977044.1. NC_021214.1.
    YP_008990337.1. NC_023151.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2NSA X-ray 1.70 A 244-405 [» ]
    2NSB X-ray 3.20 A 1-109 [» ]
    2NSC X-ray 2.20 A 1-109 [» ]
    3GTY X-ray 3.40 X 1-425 [» ]
    3GU0 X-ray 3.50 A 1-405 [» ]
    ProteinModelPortali Q9WZF8.
    SMRi Q9WZF8. Positions 1-109, 244-406.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9WZF8. 1 interaction.
    STRINGi 243274.TM0694.

    Protocols and materials databases

    DNASUi 898361.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD35776 ; AAD35776 ; TM_0694 .
    GeneIDi 898361.
    KEGGi tma:TM0694.
    tmi:THEMA_01195.
    tmm:Tmari_0694.
    PATRICi 23936306. VBITheMar51294_0706.

    Phylogenomic databases

    eggNOGi COG0544.
    KOi K03545.
    OMAi HAYQHIA.
    OrthoDBi EOG63VBX3.

    Miscellaneous databases

    EvolutionaryTracei Q9WZF8.

    Family and domain databases

    Gene3Di 1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPi MF_00303. Trigger_factor_Tig.
    InterProi IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view ]
    Pfami PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003095. Trigger_factor. 1 hit.
    SUPFAMi SSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsi TIGR00115. tig. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

    Entry informationi

    Entry nameiTIG_THEMA
    AccessioniPrimary (citable) accession number: Q9WZF8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3