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Protein

Trigger factor

Gene

tig

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Isomerase, Rotamase

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Trigger factor (EC:5.2.1.8)
Short name:
TF
Alternative name(s):
PPIase
Gene namesi
Name:tig
Ordered Locus Names:TM_0694
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

  • Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001794521 – 425Trigger factorAdd BLAST425

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
rpsGP385265EBI-2463534,EBI-2463521

Protein-protein interaction databases

IntActiQ9WZF8. 1 interactor.
STRINGi243274.TM0694.

Structurei

Secondary structure

1425
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 9Combined sources8
Beta strandi12 – 18Combined sources7
Helixi21 – 36Combined sources16
Beta strandi42 – 44Combined sources3
Helixi51 – 58Combined sources8
Helixi59 – 61Combined sources3
Helixi62 – 71Combined sources10
Helixi74 – 77Combined sources4
Turni78 – 80Combined sources3
Beta strandi83 – 85Combined sources3
Beta strandi88 – 94Combined sources7
Beta strandi99 – 107Combined sources9
Beta strandi110 – 112Combined sources3
Helixi116 – 118Combined sources3
Beta strandi119 – 124Combined sources6
Helixi126 – 144Combined sources19
Beta strandi148 – 150Combined sources3
Beta strandi159 – 168Combined sources10
Beta strandi174 – 183Combined sources10
Helixi193 – 196Combined sources4
Beta strandi204 – 211Combined sources8
Beta strandi214 – 228Combined sources15
Helixi235 – 239Combined sources5
Beta strandi241 – 244Combined sources4
Helixi248 – 254Combined sources7
Helixi259 – 262Combined sources4
Helixi267 – 278Combined sources12
Helixi279 – 282Combined sources4
Beta strandi284 – 286Combined sources3
Helixi289 – 305Combined sources17
Helixi309 – 314Combined sources6
Helixi319 – 347Combined sources29
Helixi353 – 367Combined sources15
Helixi371 – 380Combined sources10
Helixi382 – 402Combined sources21
Beta strandi405 – 410Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NSAX-ray1.70A244-405[»]
2NSBX-ray3.20A1-109[»]
2NSCX-ray2.20A1-109[»]
3GTYX-ray3.40X1-425[»]
3GU0X-ray3.50A1-405[»]
ProteinModelPortaliQ9WZF8.
SMRiQ9WZF8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WZF8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 231PPIase FKBP-typeAdd BLAST74

Domaini

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.By similarity

Sequence similaritiesi

Belongs to the FKBP-type PPIase family. Tig subfamily.Curated
Contains 1 PPIase FKBP-type domain.Curated

Phylogenomic databases

eggNOGiENOG4107XYV. Bacteria.
COG0544. LUCA.
InParanoidiQ9WZF8.
KOiK03545.
OMAiPRIIDQR.

Family and domain databases

Gene3Di1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPiMF_00303. Trigger_factor_Tig. 1 hit.
InterProiIPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamiPF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view]
PIRSFiPIRSF003095. Trigger_factor. 1 hit.
SUPFAMiSSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsiTIGR00115. tig. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WZF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVKELERDK NRVVLEYVFG AEEIAQAEDK AVRYLNQRVE IPGFRKGRIP
60 70 80 90 100
KNVLKMKLGE EFQEYTLDFL MDLIPDTLKD RKLILSPIVT ERELKDVTAR
110 120 130 140 150
VVVEVHEEPE VRIGDISKIE VEKVDEEKVL EKYVERRIED LRESHALLEP
160 170 180 190 200
KEGPAEAGDL VRVNMEVYNE EGKKLTSREY EYVISEDEDR PFVKDLVGKK
210 220 230 240 250
KGDVVEIERE YEGKKYTYKL EVEEVYKRTL PEIGDELAKS VNNEFETLEQ
260 270 280 290 300
LKESLKKEGK EIYDVEMKES MREQLLEKLP EIVEIEISDR TLEILVNEAI
310 320 330 340 350
NRLKREGRYE QIVSSYESEE KFREELKERI LDDIKRDRVI EVLAQEKGIS
360 370 380 390 400
VNDEELEKEA EELAPFWGIS PDRAKSLVKA RQDLREELRW AILKRKVLDL
410 420
LLQEVKVKVV EPKGEGDDSE GKEDN
Length:425
Mass (Da):49,898
Last modified:November 1, 1999 - v1
Checksum:iBEC16F20ACFDD922
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35776.1.
PIRiD72345.
RefSeqiNP_228503.1. NC_000853.1.
WP_004081061.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD35776; AAD35776; TM_0694.
GeneIDi898361.
KEGGitma:TM0694.
PATRICi23936306. VBITheMar51294_0706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35776.1.
PIRiD72345.
RefSeqiNP_228503.1. NC_000853.1.
WP_004081061.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NSAX-ray1.70A244-405[»]
2NSBX-ray3.20A1-109[»]
2NSCX-ray2.20A1-109[»]
3GTYX-ray3.40X1-425[»]
3GU0X-ray3.50A1-405[»]
ProteinModelPortaliQ9WZF8.
SMRiQ9WZF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WZF8. 1 interactor.
STRINGi243274.TM0694.

Protocols and materials databases

DNASUi898361.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35776; AAD35776; TM_0694.
GeneIDi898361.
KEGGitma:TM0694.
PATRICi23936306. VBITheMar51294_0706.

Phylogenomic databases

eggNOGiENOG4107XYV. Bacteria.
COG0544. LUCA.
InParanoidiQ9WZF8.
KOiK03545.
OMAiPRIIDQR.

Miscellaneous databases

EvolutionaryTraceiQ9WZF8.

Family and domain databases

Gene3Di1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPiMF_00303. Trigger_factor_Tig. 1 hit.
InterProiIPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamiPF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view]
PIRSFiPIRSF003095. Trigger_factor. 1 hit.
SUPFAMiSSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsiTIGR00115. tig. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTIG_THEMA
AccessioniPrimary (citable) accession number: Q9WZF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.