Q9WZD3 (Q9WZD3_THEMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Cysteine synthase RuleBase RU003985
EC=2.5.1.47 RuleBase RU003985

Gene names

Ordered Locus Names:

TM_0665

Organism

Thermotoga maritima

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	O(3)-acetyl-L-serine + H2S = L-cysteine + acetate. RuleBase RU003985
Sequence similarities	Belongs to the cysteine synthase/cystathionine beta-synthase family. RuleBase RU003985

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Cysteine biosynthesis RuleBase RU003985
Molecular function	Transferase RuleBase RU003985
Technical term	3D-structure PDB 1O58 Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cysteine biosynthetic process from serine Inferred from electronic annotation. Source: InterPro
Molecular function	cysteine synthase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9WZD3 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 2089B88B573411EE	FASTA	291	31,130
	10 20 30 40 50 60 MMERLIGSTP IVRLDSIDSR IFLKLEKNNP GGSVKDRPAL FMILDAEKRG LLKNGIVEPT 70 80 90 100 110 120 SGNMGIAIAM IGAKRGHRVI LTMPETMSVE RRKVLKMLGA ELVLTPGELG MKGAVEKALE 130 140 150 160 170 180 ISRETGAHML NQFENPYNVY SHQFTTGPEI LKQMDYQIDA FVAGVGTGGT ISGVGRVLKG 190 200 210 220 230 240 FFGNGVKIVA VEPAKSPVLS GGQPGKHAIQ GIGAGFVPKI LDRSVIDEVI TVEDEEAYEM 250 260 270 280 290 ARYLAKKEGL LVGISSGANV AAALKVAQKL GPDARVVTVA PDHAERYLSI L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
[2]	"Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution." Heine A., Canaves J.M., von Delft F., Brinen L.S., Dai X., Deacon A.M., Elsliger M.A., Eshaghi S., Floyd R., Godzik A., Grittini C., Grzechnik S.K., Guda C., Jaroszewski L., Karlak C., Klock H.E., Koesema E., Kovarik J.S. , Kreusch A., Kuhn P., Lesley S.A., McMullan D., McPhillips T.M., Miller M.A., Miller M.D., Morse A., Moy K., Ouyang J., Page R., Robb A., Rodrigues K., Schwarzenbacher R., Selby T.L., Spraggon G., Stevens R.C., van den Bedem H., Velasquez J., Vincent J., Wang X., West B., Wolf G., Hodgson K.O., Wooley J., Wilson I.A. Proteins 56:387-391(2004) [PubMed: 15211522] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000512 Genomic DNA. Translation: AAD35748.1.

PIR

F72349.

RefSeq

NP_228474.1. NC_000853.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1O58	X-ray	1.80	A/B/C/D	1-291	[»]

ProteinModelPortal

Q9WZD3.

SMR

Q9WZD3. Positions 1-291.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

897780.

GenomeReviews

Gene locus TM_0665 in contig AE000512_GR.

KEGG

tma:TM0665.

NMPDR

fig|243274.1.peg.658.

PATRIC

23936244. VBITheMar51294_0675.

TIGR

TM_0665.

Phylogenomic databases

HOGENOM

HBG748215.

OMA

RRNMIKA.

PhylomeDB

Q9WZD3.

ProtClustDB

CLSK875280.

Enzyme and pathway databases

BioCyc

TMAR243274:TM_0665-MONOMER.

Family and domain databases

InterPro

IPR001216. Cys_synth_BS.
IPR005856. Cys_synthKM.
IPR005859. CysK.
IPR001926. PyrdxlP-dep_enz_bsu.
[Graphical view]

KO

K01738.

Pfam

PF00291. PALP. 1 hit.
[Graphical view]

SUPFAM

SSF53686. PyrdxlP-dep_enz_bsu. 1 hit.

TIGRFAMs

TIGR01139. CysK. 1 hit.
TIGR01136. CysKM. 1 hit.

PROSITE

PS00901. CYS_SYNTHASE. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q9WZD3_THEMA

Accession

Primary (citable) accession number: Q9WZD3

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	December 14, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)