Unreviewed, UniProtKB/TrEMBL Q9WZD3 (Q9WZD3_THEMA)

Names and origin

Protein names

Recommended name:
    Cysteine synthase RuleBase RU003985V0
    EC=2.5.1.47

Gene names

Ordered Locus Names:

TM_0665

Organism

Thermotoga maritima [Complete proteome] [HAMAP]

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	O(3)-acetyl-L-serine + H2S = L-cysteine + acetate. RuleBase RU003985V0
Sequence similarities	Belongs to the cysteine synthase/cystathionine beta-synthase family. RuleBase RU003985V0

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Cysteine biosynthesis RuleBase RU003985V0
Molecular function	Transferase RuleBase RU003985V0
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cysteine biosynthetic process from serine Inferred from electronic annotation. Source: InterPro
Molecular function	cysteine synthase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9WZD3-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 2089B88B573411EE	FASTA	291	31,130
	10 20 30 40 50 60 MMERLIGSTP IVRLDSIDSR IFLKLEKNNP GGSVKDRPAL FMILDAEKRG LLKNGIVEPT 70 80 90 100 110 120 SGNMGIAIAM IGAKRGHRVI LTMPETMSVE RRKVLKMLGA ELVLTPGELG MKGAVEKALE 130 140 150 160 170 180 ISRETGAHML NQFENPYNVY SHQFTTGPEI LKQMDYQIDA FVAGVGTGGT ISGVGRVLKG 190 200 210 220 230 240 FFGNGVKIVA VEPAKSPVLS GGQPGKHAIQ GIGAGFVPKI LDRSVIDEVI TVEDEEAYEM 250 260 270 280 290 ARYLAKKEGL LVGISSGANV AAALKVAQKL GPDARVVTVA PDHAERYLSI L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
[2]	"Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution." Heine A., Canaves J.M., von Delft F., Brinen L.S., Dai X., Deacon A.M., Elsliger M.A., Eshaghi S., Floyd R., Godzik A., Grittini C., Grzechnik S.K., Guda C., Jaroszewski L., Karlak C., Klock H.E., Koesema E., Kovarik J.S. , Kreusch A., Kuhn P., Lesley S.A., McMullan D., McPhillips T.M., Miller M.A., Miller M.D., Morse A., Moy K., Ouyang J., Page R., Robb A., Rodrigues K., Schwarzenbacher R., Selby T.L., Spraggon G., Stevens R.C., van den Bedem H., Velasquez J., Vincent J., Wang X., West B., Wolf G., Hodgson K.O., Wooley J., Wilson I.A. Proteins 56:387-391(2004) [PubMed: 15211522] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).

Cross-references

Sequence databases

EMBLGenBankDDBJ

AE000512 Genomic DNA. Translation: AAD35748.1.

PIR

F72349.

RefSeq

NP_228474.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1O58	X-ray	1.80	A/B/C/D	1-291	[»]

ModBase

Search...

Genome annotation databases

GeneID

897780.

GenomeReviews

Gene locus TM_0665 in contig AE000512_GR.

KEGG

tma:TM0665.

NMPDR

fig|243274.1.peg.658.

TIGR

TM_0665.

Phylogenomic databases

HOGENOM

Q9WZD3.

OMA

TVIYAVE

Enzyme and pathway databases

BioCyc

TMAR243274:TM_0665-MON.

Family and domain databases

InterPro

IPR001216. Cys_synth_BS.
IPR005856. Cys_synthKM.
IPR005859. CysK.
IPR001926. PyrdxlP-dep_enz_bsu.
[Graphical view]

Pfam

PF00291. PALP. 1 hit.
[Graphical view]

TIGRFAMs

TIGR01139. cysK. 1 hit.
TIGR01136. cysKM. 1 hit.

PROSITE

PS00901. CYS_SYNTHASE. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q9WZD3_THEMA

Accession

Primary (citable) accession number: Q9WZD3

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	November 3, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)