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Q9WZ31 (CORA_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Magnesium transport protein CorA
Gene names
Name:corA
Ordered Locus Names:TM_0561
OrganismThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [Reference proteome] [HAMAP]
Taxonomic identifier243274 [NCBI]
Taxonomic lineageBacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga ›

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates influx of magnesium ions By similarity.

Subunit structure

Homopentamer. Ref.2 Ref.3

Subcellular location

Cell inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Magnesium transport protein CorA
PRO_0000239049

Regions

Topological domain1 – 292292Cytoplasmic Potential
Transmembrane293 – 31321Helical; Potential
Topological domain314 – 32411Periplasmic Potential
Transmembrane325 – 34521Helical; Potential
Topological domain346 – 3516Cytoplasmic Potential
Coiled coil178 – 22548 Potential
Compositional bias346 – 3494Poly-Lys

Secondary structure

1 ........................................ 351
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9WZ31 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 6A845EC612A4A0BA

FASTA35141,446
        10         20         30         40         50         60 
MEEKRLSAKK GLPPGTLVYT GKYREDFEIE VMNYSIEEFR EFKTTDVESV LPFRDSSTPT 

        70         80         90        100        110        120 
WINITGIHRT DVVQRVGEFF GIHPLVLEDI LNVHQRPKVE FFENYVFIVL KMFTYDKNLH 

       130        140        150        160        170        180 
ELESEQVSLI LTKNCVLMFQ EKIGDVFDPV RERIRYNRGI IRKKRADYLL YSLIDALVDD 

       190        200        210        220        230        240 
YFVLLEKIDD EIDVLEEEVL ERPEKETVQR THQLKRNLVE LRKTIWPLRE VLSSLYRDVP 

       250        260        270        280        290        300 
PLIEKETVPY FRDVYDHTIQ IADTVETFRD IVSGLLDVYL SSVSNKTNEV MKVLTIIATI 

       310        320        330        340        350 
FMPLTFIAGI YGMNFEYMPE LRWKWGYPVV LAVMGVIAVI MVVYFKKKKW L

« Hide

References

« Hide 'large scale' references
[1]"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima."
Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. expand/collapse author list , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M.
Nature 399:323-329(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
[2]"Crystal structure of the CorA Mg2+ transporter."
Lunin V.V., Dobrovetsky E., Khutoreskaya G., Zhang R., Joachimiak A., Doyle D.A., Bochkarev A., Maguire M.E., Edwards A.M., Koth C.M.
Nature 440:833-837(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS), SUBUNIT, TOPOLOGY.
[3]"Crystal structure of a divalent metal ion transporter CorA at 2.9 Angstrom resolution."
Eshaghi S., Niegowski D., Kohl A., Molina D.M., Lesley S.A., Nordlund P.
Science 313:354-357(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS), SUBUNIT, TOPOLOGY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000512 Genomic DNA. Translation: AAD35646.1.
PIRH72360.
RefSeqNP_228371.1. NC_000853.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2BBHX-ray1.85A1-266[»]
2BBJX-ray3.90A/B/D/E/F1-351[»]
2HN2X-ray3.70A/B/C/D/E1-351[»]
2IUBX-ray2.90A/B/C/D/E/F/G/H/I/J1-351[»]
4EEBX-ray3.80A/B/C/D/E26-351[»]
4EEDX-ray3.92A/B/C/D/E26-351[»]
4I0UX-ray2.70A/B/C/D/E/F/G/H/I/J1-351[»]
ProteinModelPortalQ9WZ31.
SMRQ9WZ31. Positions 5-349.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-59006N.
STRING243274.TM0561.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD35646; AAD35646; TM_0561.
GeneID897621.
KEGGtma:TM0561.
PATRIC23936029. VBITheMar51294_0569.

Phylogenomic databases

eggNOGCOG0598.
KOK03284.
OMADCFDIVR.
ProtClustDBCLSK875211.

Enzyme and pathway databases

BRENDA3.6.3.2. 6331.

Family and domain databases

InterProIPR004488. Mg/Co-transport_prot_CorA.
IPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
[Graphical view]
PfamPF01544. CorA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00383. corA. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ9WZ31.

Entry information

Entry nameCORA_THEMA
AccessionPrimary (citable) accession number: Q9WZ31
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1999
Last modified: May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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