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Protein
Submitted name:

Malate oxidoreductase

Gene

TM_0542

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Divalent metal cations. Prefers magnesium or manganese.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei32 – 321Proton donorUniRule annotation
Active sitei87 – 871Proton acceptorUniRule annotation
Metal bindingi87 – 871ZincCombined sources
Metal bindingi129 – 1291Divalent metal cationUniRule annotation
Metal bindingi129 – 1291ZincCombined sources
Metal bindingi130 – 1301Divalent metal cationUniRule annotation
Metal bindingi130 – 1301ZincCombined sources
Metal bindingi155 – 1551Divalent metal cationUniRule annotation
Metal bindingi155 – 1551ZincCombined sources
Binding sitei159 – 1591NADCombined sources
Binding sitei314 – 3141NADCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi186 – 1916NADCombined sources
Nucleotide bindingi211 – 2122NADCombined sources
Nucleotide bindingi259 – 2602NADCombined sources
Nucleotide bindingi281 – 2833NADCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

Metal-bindingUniRule annotationCombined sources, NADCombined sources, Nucleotide-bindingCombined sources, ZincCombined sources

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-566-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Malate oxidoreductaseImported
Submitted name:
NAD-dependent malic enzymeImported (EC:1.1.1.38Imported)
Gene namesi
Ordered Locus Names:TM_0542Imported
ORF Names:Tmari_0539Imported
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Imported
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000013901 Componenti: Chromosome
  • UP000008183 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0542.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VL6X-ray2.61A/B/C/D1-376[»]
2HAEX-ray3.13A/B/C/D2-376[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini156 – 376221Malic_MInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4107QU4. Bacteria.
COG0281. LUCA.
KOiK00027.
OMAiCNVPVFH.
OrthoDBiEOG6QCD9W.

Family and domain databases

Gene3Di3.40.50.10380. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR012301. Malic_N_dom.
IPR012302. Malic_NAD-bd.
IPR001891. Malic_OxRdtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00390. malic. 2 hits.
PF03949. Malic_M. 1 hit.
[Graphical view]
PIRSFiPIRSF000106. ME. 1 hit.
SMARTiSM01274. malic. 1 hit.
SM00919. Malic_M. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WZ12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDALEIHRFL KGKIRTALPV EKVDRETLSL LYTPGVADVA RACAEDPEKT
60 70 80 90 100
YVYTSRWNTV AVVSDGSAVL GLGNIGPYGA LPVMEGKAFL FKAFADIDAF
110 120 130 140 150
PICLSESEEE KIISIVKSLE PSFGGINLED IGAPKCFRIL QRLSEEMNIP
160 170 180 190 200
VFHDDQQGTA VVVSAAFLNA LKLTEKKIEE VKVVVNGIGA AGYNIVKFLL
210 220 230 240 250
DLGVKNVVAV DRKGILNEND PETCLNEYHL EIARITNPER LSGDLETALE
260 270 280 290 300
GADFFIGVSR GNILKPEWIK KMSRKPVIFA LANPVPEIDP ELAREAGAFI
310 320 330 340 350
VATGRSDHPN QVNNLLAFPG IMKGAVEKRS KITKNMLLSA VEAIARSCEP
360 370
EPERIIPEAF DMKVHLNVYT AVKGSA
Length:376
Mass (Da):41,043
Last modified:November 1, 1999 - v1
Checksum:i101A5506E3938600
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35627.1.
CP004077 Genomic DNA. Translation: AGL49464.1.
PIRiC72364.
RefSeqiNP_228352.1. NC_000853.1.
WP_004081360.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD35627; AAD35627; TM_0542.
AGL49464; AGL49464; Tmari_0539.
GeneIDi897596.
KEGGitma:TM0542.
tmi:THEMA_01965.
tmm:Tmari_0539.
tmw:THMA_0555.
PATRICi23935991. VBITheMar51294_0550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35627.1.
CP004077 Genomic DNA. Translation: AGL49464.1.
PIRiC72364.
RefSeqiNP_228352.1. NC_000853.1.
WP_004081360.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VL6X-ray2.61A/B/C/D1-376[»]
2HAEX-ray3.13A/B/C/D2-376[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0542.

Protocols and materials databases

DNASUi897596.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35627; AAD35627; TM_0542.
AGL49464; AGL49464; Tmari_0539.
GeneIDi897596.
KEGGitma:TM0542.
tmi:THEMA_01965.
tmm:Tmari_0539.
tmw:THMA_0555.
PATRICi23935991. VBITheMar51294_0550.

Phylogenomic databases

eggNOGiENOG4107QU4. Bacteria.
COG0281. LUCA.
KOiK00027.
OMAiCNVPVFH.
OrthoDBiEOG6QCD9W.

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-566-MONOMER.

Family and domain databases

Gene3Di3.40.50.10380. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR012301. Malic_N_dom.
IPR012302. Malic_NAD-bd.
IPR001891. Malic_OxRdtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00390. malic. 2 hits.
PF03949. Malic_M. 1 hit.
[Graphical view]
PIRSFiPIRSF000106. ME. 1 hit.
SMARTiSM01274. malic. 1 hit.
SM00919. Malic_M. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099Imported and MSB8Imported.
  2. "The genome organization of Thermotoga maritima reflects its lifestyle."
    Latif H., Lerman J.A., Portnoy V.A., Tarasova Y., Nagarajan H., Schrimpe-Rutledge A.C., Smith R.D., Adkins J.N., Lee D.H., Qiu Y., Zengler K.
    PLoS Genet. 9:E1003485-E1003485(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099Imported and MSB8Imported.

Entry informationi

Entry nameiQ9WZ12_THEMA
AccessioniPrimary (citable) accession number: Q9WZ12
Secondary accession number(s): G4FDS9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.