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Protein

Chemotaxis protein methyltransferase

Gene

cheR

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.By similarity

Catalytic activityi

S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911S-adenosyl-L-methionineBy similarity
Binding sitei93 – 931S-adenosyl-L-methionineBy similarity
Binding sitei97 – 971S-adenosyl-L-methionineBy similarity
Binding sitei132 – 1321S-adenosyl-L-methionineBy similarity
Binding sitei155 – 1551S-adenosyl-L-methionineBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Chemotaxis

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis protein methyltransferase (EC:2.1.1.80)
Gene namesi
Name:cheR
Ordered Locus Names:TM_0464
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Chemotaxis protein methyltransferasePRO_0000176040Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0464.

Structurei

3D structure databases

ProteinModelPortaliQ9WYT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 282266CheR-type methyltransferasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni210 – 2112S-adenosyl-L-methionine bindingBy similarity
Regioni226 – 2272S-adenosyl-L-methionine bindingBy similarity

Sequence similaritiesi

Contains 1 cheR-type methyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
InParanoidiQ9WYT5.
KOiK00575.
OMAiSTEQIIM.

Family and domain databases

Gene3Di1.10.155.10. 1 hit.
3.40.50.150. 1 hit.
InterProiIPR022642. CheR_C.
IPR000780. CheR_MeTrfase.
IPR022641. CheR_N.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01739. CheR. 1 hit.
PF03705. CheR_N. 1 hit.
[Graphical view]
PRINTSiPR00996. CHERMTFRASE.
SMARTiSM00138. MeTrc. 1 hit.
[Graphical view]
SUPFAMiSSF47757. SSF47757. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS50123. CHER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WYT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEERSEKKI GPFKFQSNFE WKEFPQEEFE WFVKEVEKRF GLNLSSYKPQ
60 70 80 90 100
RVKRRTELLL RKYNVGYREY LNMLIKDKKY LDEFMDKMTI NVTEFFRNPE
110 120 130 140 150
KWWELRDEII PLIAKNSLRM KFWSAGCSSG EEPYSLAILV HELNLSYKTR
160 170 180 190 200
ILATDIDIGV LRRAQEGIYE ERAFVSTPKE YLEKYFEKLP DGRYRIKDSV
210 220 230 240 250
KKIVEFKRHD LLKDPFEKNF DLIVCRNVVI YFEPEAKNEL YRKFAESLKP
260 270 280
GGFLFVGNTE RIFNYKELGF EIYKPFIYRK VK
Length:282
Mass (Da):34,225
Last modified:November 1, 1999 - v1
Checksum:iF3D5910026E9E0B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35548.1.
PIRiH72373.
RefSeqiNP_228274.1. NC_000853.1.
WP_004081502.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD35548; AAD35548; TM_0464.
GeneIDi897495.
KEGGitma:TM0464.
tmi:THEMA_02370.
tmw:THMA_0473.
PATRICi23935825. VBITheMar51294_0471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35548.1.
PIRiH72373.
RefSeqiNP_228274.1. NC_000853.1.
WP_004081502.1. NZ_CP011107.1.

3D structure databases

ProteinModelPortaliQ9WYT5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0464.

Protocols and materials databases

DNASUi897495.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35548; AAD35548; TM_0464.
GeneIDi897495.
KEGGitma:TM0464.
tmi:THEMA_02370.
tmw:THMA_0473.
PATRICi23935825. VBITheMar51294_0471.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
InParanoidiQ9WYT5.
KOiK00575.
OMAiSTEQIIM.

Family and domain databases

Gene3Di1.10.155.10. 1 hit.
3.40.50.150. 1 hit.
InterProiIPR022642. CheR_C.
IPR000780. CheR_MeTrfase.
IPR022641. CheR_N.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01739. CheR. 1 hit.
PF03705. CheR_N. 1 hit.
[Graphical view]
PRINTSiPR00996. CHERMTFRASE.
SMARTiSM00138. MeTrc. 1 hit.
[Graphical view]
SUPFAMiSSF47757. SSF47757. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS50123. CHER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHER_THEMA
AccessioniPrimary (citable) accession number: Q9WYT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.