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Q9WYQ4

- GLDA_THEMA

UniProt

Q9WYQ4 - GLDA_THEMA

Protein

Glycerol dehydrogenase

Gene

gldA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions By similarity.By similarity

    Catalytic activityi

    Glycerol + NAD+ = glycerone + NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371NADBy similarity
    Binding sitei119 – 1191SubstrateCurated
    Binding sitei123 – 1231NADBy similarity
    Binding sitei125 – 1251NAD; via carbonyl oxygenBy similarity
    Binding sitei129 – 1291NADBy similarity
    Metal bindingi169 – 1691Zinc; catalytic1 Publication
    Binding sitei169 – 1691SubstrateCurated
    Metal bindingi252 – 2521Zinc; catalytic1 Publication
    Binding sitei252 – 2521SubstrateCurated
    Metal bindingi269 – 2691Zinc; catalytic1 Publication
    Binding sitei269 – 2691SubstrateCurated

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi92 – 965NADBy similarity
    Nucleotide bindingi114 – 1174NADBy similarity

    GO - Molecular functioni

    1. glycerol dehydrogenase [NAD+] activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. anaerobic glycerol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycerol metabolism

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00617; UER00668.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol dehydrogenase (EC:1.1.1.6)
    Short name:
    GDH
    Short name:
    GLDH
    Gene namesi
    Name:gldA
    Ordered Locus Names:TM_0423
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364Glycerol dehydrogenasePRO_0000350665Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243274.TM0423.

    Structurei

    Secondary structure

    1
    364
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi9 – 146
    Helixi17 – 204
    Helixi21 – 266
    Beta strandi30 – 367
    Helixi38 – 436
    Helixi49 – 524
    Beta strandi54 – 629
    Helixi69 – 768
    Beta strandi85 – 917
    Helixi92 – 10413
    Beta strandi109 – 1157
    Beta strandi123 – 1297
    Beta strandi135 – 1406
    Beta strandi146 – 1516
    Helixi152 – 1576
    Helixi160 – 18324
    Beta strandi190 – 1923
    Helixi195 – 22026
    Helixi226 – 24621
    Helixi250 – 2589
    Helixi262 – 2643
    Helixi269 – 28315
    Helixi288 – 30114
    Helixi307 – 3104
    Helixi317 – 32711
    Helixi333 – 3364
    Beta strandi337 – 3393
    Helixi343 – 36018

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KQ3X-ray1.50A1-364[»]
    ProteinModelPortaliQ9WYQ4.
    SMRiQ9WYQ4. Positions 1-363.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9WYQ4.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0371.
    KOiK00005.
    OMAiYFEARAN.
    OrthoDBiEOG67432X.

    Family and domain databases

    InterProiIPR001670. ADH_Fe.
    IPR018211. ADH_Fe_CS.
    IPR016205. Glycerol_DH.
    [Graphical view]
    PfamiPF00465. Fe-ADH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000112. Glycerol_dehydrogenase. 1 hit.
    PROSITEiPS00913. ADH_IRON_1. 1 hit.
    PS00060. ADH_IRON_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WYQ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MITTTIFPGR YVQGAGAINI LEEELSRFGE RAFVVIDDFV DKNVLGENFF    50
    SSFTKVRVNK QIFGGECSDE EIERLSGLVE EETDVVVGIG GGKTLDTAKA 100
    VAYKLKKPVV IVPTIASTDA PCSALSVIYT PNGEFKRYLF LPRNPDVVLV 150
    DTEIVAKAPA RFLVAGMGDA LATWFEAESC KQKYAPNMTG RLGSMTAYAL 200
    ARLCYETLLE YGVLAKRSVE EKSVTPALEK IVEANTLLSG LGFESGGLAA 250
    AHAIHNGLTV LENTHKYLHG EKVAIGVLAS LFLTDKPRKM IEEVYSFCEE 300
    VGLPTTLAEI GLDGVSDEDL MKVAEKACDK NETIHNEPQP VTSKDVFFAL 350
    KAADRYGRMR KNLT 364
    Length:364
    Mass (Da):39,692
    Last modified:November 1, 1999 - v1
    Checksum:iB44E20CACC6F1582
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD35508.1.
    PIRiG72378.
    RefSeqiNP_228233.1. NC_000853.1.
    YP_007976770.1. NC_021214.1.
    YP_008990607.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD35508; AAD35508; TM_0423.
    GeneIDi897429.
    KEGGitma:TM0423.
    tmi:THEMA_02610.
    tmm:Tmari_0420.
    PATRICi23935729. VBITheMar51294_0428.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD35508.1 .
    PIRi G72378.
    RefSeqi NP_228233.1. NC_000853.1.
    YP_007976770.1. NC_021214.1.
    YP_008990607.1. NC_023151.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KQ3 X-ray 1.50 A 1-364 [» ]
    ProteinModelPortali Q9WYQ4.
    SMRi Q9WYQ4. Positions 1-363.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243274.TM0423.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD35508 ; AAD35508 ; TM_0423 .
    GeneIDi 897429.
    KEGGi tma:TM0423.
    tmi:THEMA_02610.
    tmm:Tmari_0420.
    PATRICi 23935729. VBITheMar51294_0428.

    Phylogenomic databases

    eggNOGi COG0371.
    KOi K00005.
    OMAi YFEARAN.
    OrthoDBi EOG67432X.

    Enzyme and pathway databases

    UniPathwayi UPA00617 ; UER00668 .

    Miscellaneous databases

    EvolutionaryTracei Q9WYQ4.

    Family and domain databases

    InterProi IPR001670. ADH_Fe.
    IPR018211. ADH_Fe_CS.
    IPR016205. Glycerol_DH.
    [Graphical view ]
    Pfami PF00465. Fe-ADH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000112. Glycerol_dehydrogenase. 1 hit.
    PROSITEi PS00913. ADH_IRON_1. 1 hit.
    PS00060. ADH_IRON_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
    2. Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) IN COMPLEX WITH ZINC AND SUBSTRATE ANALOG.
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

    Entry informationi

    Entry nameiGLDA_THEMA
    AccessioniPrimary (citable) accession number: Q9WYQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 23, 2008
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3