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Q9WYQ4

- GLDA_THEMA

UniProt

Q9WYQ4 - GLDA_THEMA

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Protein
Glycerol dehydrogenase
Gene
gldA, TM_0423
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions By similarity.

Catalytic activityi

Glycerol + NAD+ = glycerone + NADH.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371NAD By similarity
Binding sitei119 – 1191Substrate Inferred
Binding sitei123 – 1231NAD By similarity
Binding sitei125 – 1251NAD; via carbonyl oxygen By similarity
Binding sitei129 – 1291NAD By similarity
Metal bindingi169 – 1691Zinc; catalytic
Binding sitei169 – 1691Substrate Inferred
Metal bindingi252 – 2521Zinc; catalytic
Binding sitei252 – 2521Substrate Inferred
Metal bindingi269 – 2691Zinc; catalytic
Binding sitei269 – 2691Substrate Inferred

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi92 – 965NAD By similarity
Nucleotide bindingi114 – 1174NAD By similarity

GO - Molecular functioni

  1. glycerol dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. anaerobic glycerol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00617; UER00668.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol dehydrogenase (EC:1.1.1.6)
Short name:
GDH
Short name:
GLDH
Gene namesi
Name:gldA
Ordered Locus Names:TM_0423
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Glycerol dehydrogenase
PRO_0000350665Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0423.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 146
Helixi17 – 204
Helixi21 – 266
Beta strandi30 – 367
Helixi38 – 436
Helixi49 – 524
Beta strandi54 – 629
Helixi69 – 768
Beta strandi85 – 917
Helixi92 – 10413
Beta strandi109 – 1157
Beta strandi123 – 1297
Beta strandi135 – 1406
Beta strandi146 – 1516
Helixi152 – 1576
Helixi160 – 18324
Beta strandi190 – 1923
Helixi195 – 22026
Helixi226 – 24621
Helixi250 – 2589
Helixi262 – 2643
Helixi269 – 28315
Helixi288 – 30114
Helixi307 – 3104
Helixi317 – 32711
Helixi333 – 3364
Beta strandi337 – 3393
Helixi343 – 36018

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KQ3X-ray1.50A1-364[»]
ProteinModelPortaliQ9WYQ4.
SMRiQ9WYQ4. Positions 1-363.

Miscellaneous databases

EvolutionaryTraceiQ9WYQ4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0371.
KOiK00005.
OMAiYFEARAN.
OrthoDBiEOG67432X.

Family and domain databases

InterProiIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
IPR016205. Glycerol_DH.
[Graphical view]
PfamiPF00465. Fe-ADH. 1 hit.
[Graphical view]
PIRSFiPIRSF000112. Glycerol_dehydrogenase. 1 hit.
PROSITEiPS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WYQ4-1 [UniParc]FASTAAdd to Basket

« Hide

MITTTIFPGR YVQGAGAINI LEEELSRFGE RAFVVIDDFV DKNVLGENFF    50
SSFTKVRVNK QIFGGECSDE EIERLSGLVE EETDVVVGIG GGKTLDTAKA 100
VAYKLKKPVV IVPTIASTDA PCSALSVIYT PNGEFKRYLF LPRNPDVVLV 150
DTEIVAKAPA RFLVAGMGDA LATWFEAESC KQKYAPNMTG RLGSMTAYAL 200
ARLCYETLLE YGVLAKRSVE EKSVTPALEK IVEANTLLSG LGFESGGLAA 250
AHAIHNGLTV LENTHKYLHG EKVAIGVLAS LFLTDKPRKM IEEVYSFCEE 300
VGLPTTLAEI GLDGVSDEDL MKVAEKACDK NETIHNEPQP VTSKDVFFAL 350
KAADRYGRMR KNLT 364
Length:364
Mass (Da):39,692
Last modified:November 1, 1999 - v1
Checksum:iB44E20CACC6F1582
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD35508.1.
PIRiG72378.
RefSeqiNP_228233.1. NC_000853.1.
YP_007976770.1. NC_021214.1.
YP_008990607.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD35508; AAD35508; TM_0423.
GeneIDi897429.
KEGGitma:TM0423.
tmi:THEMA_02610.
tmm:Tmari_0420.
PATRICi23935729. VBITheMar51294_0428.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD35508.1 .
PIRi G72378.
RefSeqi NP_228233.1. NC_000853.1.
YP_007976770.1. NC_021214.1.
YP_008990607.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1KQ3 X-ray 1.50 A 1-364 [» ]
ProteinModelPortali Q9WYQ4.
SMRi Q9WYQ4. Positions 1-363.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243274.TM0423.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD35508 ; AAD35508 ; TM_0423 .
GeneIDi 897429.
KEGGi tma:TM0423.
tmi:THEMA_02610.
tmm:Tmari_0420.
PATRICi 23935729. VBITheMar51294_0428.

Phylogenomic databases

eggNOGi COG0371.
KOi K00005.
OMAi YFEARAN.
OrthoDBi EOG67432X.

Enzyme and pathway databases

UniPathwayi UPA00617 ; UER00668 .

Miscellaneous databases

EvolutionaryTracei Q9WYQ4.

Family and domain databases

InterProi IPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
IPR016205. Glycerol_DH.
[Graphical view ]
Pfami PF00465. Fe-ADH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000112. Glycerol_dehydrogenase. 1 hit.
PROSITEi PS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) IN COMPLEX WITH ZINC AND SUBSTRATE ANALOG.
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiGLDA_THEMA
AccessioniPrimary (citable) accession number: Q9WYQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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