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Q9WYQ4

- GLDA_THEMA

UniProt

Q9WYQ4 - GLDA_THEMA

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Protein

Glycerol dehydrogenase

Gene

gldA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions By similarity.By similarity

Catalytic activityi

Glycerol + NAD+ = glycerone + NADH.

Cofactori

Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371NADBy similarity
Binding sitei119 – 1191SubstrateCurated
Binding sitei123 – 1231NADBy similarity
Binding sitei125 – 1251NAD; via carbonyl oxygenBy similarity
Binding sitei129 – 1291NADBy similarity
Metal bindingi169 – 1691Zinc; catalytic1 Publication
Binding sitei169 – 1691SubstrateCurated
Metal bindingi252 – 2521Zinc; catalytic1 Publication
Binding sitei252 – 2521SubstrateCurated
Metal bindingi269 – 2691Zinc; catalytic1 Publication
Binding sitei269 – 2691SubstrateCurated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi92 – 965NADBy similarity
Nucleotide bindingi114 – 1174NADBy similarity

GO - Molecular functioni

  1. glycerol dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. anaerobic glycerol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00617; UER00668.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol dehydrogenase (EC:1.1.1.6)
Short name:
GDH
Short name:
GLDH
Gene namesi
Name:gldA
Ordered Locus Names:TM_0423
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Glycerol dehydrogenasePRO_0000350665Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0423.

Structurei

Secondary structure

1
364
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 146
Helixi17 – 204
Helixi21 – 266
Beta strandi30 – 367
Helixi38 – 436
Helixi49 – 524
Beta strandi54 – 629
Helixi69 – 768
Beta strandi85 – 917
Helixi92 – 10413
Beta strandi109 – 1157
Beta strandi123 – 1297
Beta strandi135 – 1406
Beta strandi146 – 1516
Helixi152 – 1576
Helixi160 – 18324
Beta strandi190 – 1923
Helixi195 – 22026
Helixi226 – 24621
Helixi250 – 2589
Helixi262 – 2643
Helixi269 – 28315
Helixi288 – 30114
Helixi307 – 3104
Helixi317 – 32711
Helixi333 – 3364
Beta strandi337 – 3393
Helixi343 – 36018

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KQ3X-ray1.50A1-364[»]
ProteinModelPortaliQ9WYQ4.
SMRiQ9WYQ4. Positions 1-363.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WYQ4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0371.
InParanoidiQ9WYQ4.
KOiK00005.
OMAiYFEARAN.
OrthoDBiEOG67432X.

Family and domain databases

InterProiIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
IPR016205. Glycerol_DH.
[Graphical view]
PfamiPF00465. Fe-ADH. 1 hit.
[Graphical view]
PIRSFiPIRSF000112. Glycerol_dehydrogenase. 1 hit.
PROSITEiPS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WYQ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITTTIFPGR YVQGAGAINI LEEELSRFGE RAFVVIDDFV DKNVLGENFF
60 70 80 90 100
SSFTKVRVNK QIFGGECSDE EIERLSGLVE EETDVVVGIG GGKTLDTAKA
110 120 130 140 150
VAYKLKKPVV IVPTIASTDA PCSALSVIYT PNGEFKRYLF LPRNPDVVLV
160 170 180 190 200
DTEIVAKAPA RFLVAGMGDA LATWFEAESC KQKYAPNMTG RLGSMTAYAL
210 220 230 240 250
ARLCYETLLE YGVLAKRSVE EKSVTPALEK IVEANTLLSG LGFESGGLAA
260 270 280 290 300
AHAIHNGLTV LENTHKYLHG EKVAIGVLAS LFLTDKPRKM IEEVYSFCEE
310 320 330 340 350
VGLPTTLAEI GLDGVSDEDL MKVAEKACDK NETIHNEPQP VTSKDVFFAL
360
KAADRYGRMR KNLT
Length:364
Mass (Da):39,692
Last modified:November 1, 1999 - v1
Checksum:iB44E20CACC6F1582
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD35508.1.
PIRiG72378.
RefSeqiNP_228233.1. NC_000853.1.
WP_004083283.1. NC_023151.1.
YP_007976770.1. NC_021214.1.
YP_008990607.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD35508; AAD35508; TM_0423.
GeneIDi18092377.
897429.
KEGGitma:TM0423.
tmi:THEMA_02610.
tmm:Tmari_0420.
PATRICi23935729. VBITheMar51294_0428.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD35508.1 .
PIRi G72378.
RefSeqi NP_228233.1. NC_000853.1.
WP_004083283.1. NC_023151.1.
YP_007976770.1. NC_021214.1.
YP_008990607.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1KQ3 X-ray 1.50 A 1-364 [» ]
ProteinModelPortali Q9WYQ4.
SMRi Q9WYQ4. Positions 1-363.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM0423.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD35508 ; AAD35508 ; TM_0423 .
GeneIDi 18092377.
897429.
KEGGi tma:TM0423.
tmi:THEMA_02610.
tmm:Tmari_0420.
PATRICi 23935729. VBITheMar51294_0428.

Phylogenomic databases

eggNOGi COG0371.
InParanoidi Q9WYQ4.
KOi K00005.
OMAi YFEARAN.
OrthoDBi EOG67432X.

Enzyme and pathway databases

UniPathwayi UPA00617 ; UER00668 .

Miscellaneous databases

EvolutionaryTracei Q9WYQ4.

Family and domain databases

InterProi IPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
IPR016205. Glycerol_DH.
[Graphical view ]
Pfami PF00465. Fe-ADH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000112. Glycerol_dehydrogenase. 1 hit.
PROSITEi PS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) IN COMPLEX WITH ZINC AND SUBSTRATE ANALOG.
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiGLDA_THEMA
AccessioniPrimary (citable) accession number: Q9WYQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3