Q9WYN0 (Q9WYN0_THEMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Response regulator EMBL AAD35484.1

Submitted name:
Two component transcriptional regulator, winged helix family EMBL EHA59043.1

Gene names

Ordered Locus Names:	TM_0399
ORF Names:	ThemaDRAFT_1800 EMBL EHA59043.1

Organism

Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [Reference proteome] [HAMAP]

Taxonomic identifier

243274 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Thermotogae › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga › Thermotoga maritima

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Biological process	Two-component regulatory system SAAS SAAS001867
Ligand	Magnesium PDB 3NNN Metal-binding PDB 3NNN
PTM	Phosphoprotein SAAS SAAS001867
Technical term	3D-structure PDB 3NNN PDB 1KGS Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphorelay response regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	10	1	Magnesium PDB 3NNN
	Metal binding	53	1	Magnesium PDB 3NNN
	Metal binding	55	1	Magnesium PDB 3NNN

Sequences

	Sequence		Length	Mass (Da)
	Q9WYN0 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 4CB1F2CC82A218F7	FASTA	225	26,015
	10 20 30 40 50 60 MNVRVLVVED ERDLADLITE ALKKEMFTVD VCYDGEEGMY MALNEPFDVV ILDIMLPVHD 70 80 90 100 110 120 GWEILKSMRE SGVNTPVLML TALSDVEYRV KGLNMGADDY LPKPFDLREL IARVRALIRR 130 140 150 160 170 180 KSESKSTKLV CGDLILDTAT KKAYRGSKEI DLTKKEYQIL EYLVMNKNRV VTKEELQEHL 190 200 210 220 WSFDDEVFSD VLRSHIKNLR KKVDKGFKKK IIHTVRGIGY VARDE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
[2]	"Evidence of intradomain and interdomain flexibility in an OmpR/PhoB homolog from Thermotoga maritima." Buckler D.R., Zhou Y., Stock A.M. Structure 10:153-164(2002) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS).
[3]	"Regulation of response regulator autophosphorylation through interdomain contacts." Barbieri C.M., Mack T.R., Robinson V.L., Miller M.T., Stock A.M. J. Biol. Chem. 285:32325-32335(2010) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 1-122 IN COMPLEX WITH MAGNESIUM.
[4]	"The draft genome of Thermotoga maritima MSB8." US DOE Joint Genome Institute (JGI-PGF) Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Land M.L., Hauser L., Boucher N., Noll K., Woyke T. Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: MSB8 EMBL EHA59043.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000512 Genomic DNA. Translation: AAD35484.1.
AGIJ01000003 Genomic DNA. Translation: EHA59043.1.

PIR

H72382.

RefSeq

NP_228209.1. NC_000853.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1KGS	X-ray	1.50	A	1-225	[»]
3NNN	X-ray	2.20	A/B	1-122	[»]

SMR

Q9WYN0. Positions 2-225.

ModBase

Search...

Protein-protein interaction databases

STRING

243274.TM0399.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAD35484; AAD35484; TM_0399.
EHA59043; EHA59043; ThemaDRAFT_1800.

GeneID

897392.

KEGG

tma:TM0399.

PATRIC

23935681. VBITheMar51294_0404.

Phylogenomic databases

KO

K02483.

OMA

ILEYLVM.

ProtClustDB

CLSK795130.

Family and domain databases

Gene3D

1.10.10.10. 1 hit.

InterPro

IPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]

Pfam

PF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]

SMART

SM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]

SUPFAM

SSF52172. CheY_like. 1 hit.

PROSITE

PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9WYN0.

Entry information

Entry name

Q9WYN0_THEMA

Accession

Primary (citable) accession number: Q9WYN0
Secondary accession number(s): G4FHV8

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)